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Application of cangamycin in the preparation of anti-inflammatory drugs

A technology of anti-inflammatory drugs and mycin, which is applied in the direction of anti-inflammatory agents, drug combinations, antipyretics, etc., can solve the problems of rare natural product separation raw materials, large toxic and side effects, and little industrial production, and achieve good NO secretion inhibition Active, strong inhibitory effect

Active Publication Date: 2019-02-26
HUANGHE S & T COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the raw materials for the isolation of natural products are scarce and of low purity, and are rarely used in industrialized production; modification of natural products by chemical synthesis can strengthen the affinity and specificity of enzymes, but they have great toxic and side effects on the human body.

Method used

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  • Application of cangamycin in the preparation of anti-inflammatory drugs

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] 1 Experimental materials

[0011] 1.1 Experimental drugs

[0012] Corgamycin and its positive control drug dexamethasone tablets, lipopolysaccharide.

[0013] 1.2 Cell lines used in experiments

[0014] Mouse mononuclear macrophage RAW264.7 was purchased from the Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. RAW264.7 cells were cultured in RPMI-1640 medium containing 10% special grade fetal bovine serum (supplemented with 100 U / mL penicillin and 100 μg / mL streptomycin) at 37 °C, 5% CO 2 in the incubator.

[0015] 1.3 Reagents used in the experiment

[0016] RPMI-1640 medium, fetal bovine serum, penicillin-streptomycin mixture (double antibody), endotoxin lipopolysaccharide, dimethyl sulfoxide, NO kit, CCK-8 kit, dexamethasone tablets, phosphate buffer liquid, 75% medical ethanol.

[0017] 1.4 Instruments and equipment used in the experiment

[0018] Instruments and equipment: ultra-clean workbench, inverted micr...

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Abstract

The invention belongs to the technical field of microbial secondary metabolism product application, and particularly relates to application of chaetomium angustispirale secondary metabolism products of cochliodinol to preparation of anti-inflammatory medicine. The cochliodinol has good NO secretion inhibition activity; the NO secretion inhibition rate of the cochliodinol can reach 96.88 percent; and the inhibition effect is obviously better than that of dexamethasone tablets.

Description

technical field [0001] The invention belongs to the technical field of application of secondary metabolites of microorganisms, and in particular relates to the application of canjunamycin, a secondary metabolite of stenotic hair shells, in the preparation of anti-inflammatory drugs. Background technique [0002] narrow spiral hair shell ( Chaetomium angustispirale ) belongs to the genus Chaetomycetes of Ascomycota, which is distributed worldwide and has important economic value and ecological significance. Studies have shown that Chaetomium, as a biocontrol fungus, can play an active role in the prevention and control of plant diseases, and most of them have the ability to degrade cellulose. Cochliodinol is a secondary metabolite of narrowly spiraled hair shells with the molecular formula C 32 h 30 N 2 o 4 ; Molecular weight: 506.22; CAS accession number: 11051-88-0, structural formula: [0003] . [0004] Inflammation is the response of living tissue with vasculatu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/404A61P29/00
CPCA61K31/404
Inventor 陈林郭庆丰张勇马经纬康文艺
Owner HUANGHE S & T COLLEGE