Multi-channel cocurrent flow microfluidic chip and controllable spinning method for linear multi-phase heterostructure fiber based on same

A technology of microfluidic chips and heterostructures, applied in the fields of fluid controller, fiber processing, fiber chemical characteristics, etc., can solve the problems of fragility and limitation of chips, achieve low cost, simple manufacturing process, and overcome high manufacturing costs. Effect

Active Publication Date: 2016-12-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the manufacturing difficulty and cost of this chip are all reduced, the material used (usually glass) itself causes the chip to be fragile, and its coaxial structure determines that the chip can only form a simple coaxial linear fluid, that is, it can only be prepared Multilayer core-shell microfibers or hollow fibers greatly limit their applications in microfluidic spinning and biomimetic scaffolds for tissue engineering

Method used

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  • Multi-channel cocurrent flow microfluidic chip and controllable spinning method for linear multi-phase heterostructure fiber based on same
  • Multi-channel cocurrent flow microfluidic chip and controllable spinning method for linear multi-phase heterostructure fiber based on same
  • Multi-channel cocurrent flow microfluidic chip and controllable spinning method for linear multi-phase heterostructure fiber based on same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The structure of the seven-channel parallel flow microfluidic chip:

[0033] structured as figure 2 As shown, there are 7 stainless steel shunt capillaries 1-1, 1-2, 1-3, 1-4, 1-5, 1-6 with an inner diameter of 80 μm, an outer diameter of 200 μm, and a length of 25 mm for each spinning solution to circulate separately. , 1-7, and a stainless steel confluence capillary 2 with an inner diameter of 600 μm, an outer diameter of 900 um, and a length of 25 mm that converges the spinning solutions flowing out of each split capillary. The inside of the confluence capillary is bonded and fixed to the port of the confluence capillary by normal temperature hardening glue, and the normal temperature hardening glue seals the socket port of the confluence capillary. The depth of inserting the shunt capillary into the sink capillary is 10mm. The way that the split capillaries are arranged side by side is to make the cross-section of the capillary bundle formed after the side-by-side ...

Embodiment 2

[0037] The seven-channel co-current microfluidic chip in Example 1 was used as the spinning spinneret, and the spinning device was connected according to the method in Example 1, and then the following hydrogel wet spinning was performed.

[0038] Hollow tubular structure microfiber spinning:

[0039] Use a multi-channel micro-injection pump to pass 2wt% sodium alginate solution at a speed of 10mL / h into the split capillary tubes marked 1-1 to 1-6, and put a 5wt% hyaluronic acid solution at a speed of 10mL / h Into the split capillary labeled 1-7; the outlet of the confluence capillary (i.e. the outlet of the seven-channel parallel flow microfluidic chip) is immersed in 100mmol / L of CaCl 2 solution (colloidal solution). Spinning solution into CaCl 2 solution, the sodium alginate component and Ca 2+ The ion chelation reaction occurs to gel, the hyaluronic acid solution does not gel, and the CaCl diffuses outside the fiber 2 solution, thereby forming hollow sodium alginate hyd...

Embodiment 3

[0041] Using the seven-channel co-current microfluidic chip in Example 1 as the spinning spinneret, the perfusion velocity of the sodium alginate solution was regulated within the range of 5 to 30 mL / h. The remaining steps and conditions were the same as in Example 2, and the obtained diameter was 600-1000 μm hollow sodium alginate hydrogel microfibers.

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Abstract

The invention provides a multi-channel cocurrent flow microfluidic chip. The chip is composed of a plurality of bypass capillary tubes and a confluence capillary tube, different spinning solutions flow through the bypass capillary tubes independently in a hydrogel wet spinning process or static spinning process, and the spinning solutions flowing out of the bypass capillary tubes are converged through the confluence capillary tube. One end of each bypass capillary tube is embedded into the confluence capillary tube to be fixed from one port of the confluence capillary tube by the same depth, and the inserting port of the confluence capillary tube is sealed. The other end of each bypass capillary tube is the inlet of the whole multi-channel cocurrent flow microfluidic chip, and the other end of the confluence capillary tube is the outlet of the whole multi-channel cocurrent flow microfluidic chip. The invention further provides a controllable spinning method for linear multi-phase heterostructure fiber based on the multi-channel cocurrent flow microfluidic chip. The technological difficulty and cost of the microfluidic chip can be lowered, the practicability and durability are improved, and various linear multi-phase heterostructure micro-nano fibers can be continuously, rapidly and conveniently manufactured.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chip manufacturing in tissue engineering bionics, and in particular relates to a multi-channel parallel flow microfluidic chip and a spinning method based on the chip. Background technique [0002] Linear structures such as muscle fibers, blood vessels, liver cords, and nerve bundles are widely distributed in humans and mammals. At the micron scale, the cells and extracellular matrices of these tissues are assembled in a complex and highly ordered manner. However, in the field of tissue engineering, the use of biomaterials and seed cells to biomimetically construct various linear structural tissues to achieve regeneration and functional recovery of diseased or damaged tissues has so far been regarded as a major challenge. The current development and rise of various micro-manufacturing technologies provide infinite possibilities for the realization of micro-nano-scale, spatiotemporal control ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00D01D4/02D01D5/00D01F8/18
CPCB01L3/5027B01L2200/10B01L2300/0861B01L2400/0406D01D4/02D01D5/0069D01F8/18
Inventor 范红松杨友孙静卫丹左一聪钟美玲
Owner SICHUAN UNIV
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