Substituted furan isoquinolinone derivatives and preparation method thereof

Abstract

The invention relates to the field of medical chemistry, and aims at providing a substituted furan flavonol derivative and a preparation method thereof. The substituted furan flavonol derivative has a structure represented by formula (I) shown in the description; and in the formula (I), B ring is selected from a phenyl group or a furyl group; and R1, R2 and R3 are respectively independently selected from the hydrogen atom, a hydroxyl group, a methoxy group, a dimethylamino group, a nitro group and a cyan group. The above product is a new skeleton natural furan isoquinolone analog and has potential drug activity, and the preparation method of the compound provides support for the drug activity researches of furan isoquinolones. The preparation method of the derivative has the advantages of simple steps and easiness in obtaining, and is of great significance to industrial production.

Description

Technical field [0001] The present invention relates to the field of medicinal chemistry, and more specifically, to a substituted furan isoquinolinone derivative and a preparation method thereof. Background technique [0002] Isoquinolinone compounds widely exist in nature, and their derivatives have a variety of biological activities such as vasodilation and anti-tumor. The molecular diversity, synthesis methods and biological activities of isoquinolinone compounds have received attention in recent years. [0003] The synthesis of isoquinoline rings has always been paid special attention by synthetic organic chemists and pharmaceutical synthetic chemists. Although there have been many reports of synthetic isoquinoline derivatives in recent years, they are not satisfactory because their reaction conditions are often It is relatively harsh, but the yield is not high, and the by-products are many, and purification is difficult. Some methods must use expensive catalysts. Therefore, it...

AI Technical Summary

Problems solved by technology

[0003] The synthesis of isoquinoline rings has always been paid special attention by organic synthetic chemists and pharmaceutical synthetic chemists. Although there have been many reports on the synthesis of isoquinoline derivatives in recent years, they are not satisfactory because their reaction conditions are often It is relatively harsh, but the yield is not high, and there are many by-products, the purification is difficult, and some methods must use expensive catalysts, so it is urgent to develop new methods for the synthesis of isoquinoline and its derivatives that are simple and effective.

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