Panel PET-led boron neutron capturing therapeutic system and neutron beam flow control method

A boron neutron capture and treatment system technology, applied in the field of positron emission tomography, can solve the problems of single time point, limitation, and inability to provide real-time, quantitative, and online distribution information, so as to ensure accuracy and reduce radiation damage effect

Active Publication Date: 2017-01-04
PEKING UNIV
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Problems solved by technology

Although pharmacokinetics provides a certain theoretical method guidance, due to the limitations of existing boron neutron capture therapy equipment and control methods, the distribution of drugs cannot be detected during irradiation
Existing temporary solutions include physical measurement, chemical measurement and nuclide measurement. However, these methods are all offline detection methods and are limited to a single time point and a single sampling point
These methods can only indirectly detect the general law of drug distribution, cannot provide real-time, quantitative, and online distribution information, and lack spatial distribution information, which is of limited help in solving the four-dimensional problem of drug distribution in boron neutron capture therapy.

Method used

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  • Panel PET-led boron neutron capturing therapeutic system and neutron beam flow control method
  • Panel PET-led boron neutron capturing therapeutic system and neutron beam flow control method
  • Panel PET-led boron neutron capturing therapeutic system and neutron beam flow control method

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Embodiment 1

[0038] Such as figure 1 As shown, in this embodiment, the flat-panel PET detector and the beam exit device are separated, and the neutron targeted irradiation is performed in a vertical posture. The boron neutron capture therapy system guided by the flat-panel PET in this embodiment includes: the beam exit device 1. Flat-panel PET detector 2, rotating mechanism 3, frame 4, motor control mechanism 5, irradiation bed 6, crystal shielding device 7, optical positioning and tracking system 8, detector motor 9 and workstation; wherein, irradiation bed 6 is installed on on the motor control mechanism 5; the irradiated sample is placed on the irradiated bed 6, and the irradiated field of view is formed above the irradiated sample; the rotating mechanism 3 is installed on the frame 4, and a pair of flat-panel PET detectors 2 are respectively installed on the rotation axis through their respective detector motors 9. On the mechanism 3, and respectively located on the opposite side of th...

Embodiment 2

[0042] Such as figure 2 As shown, in this embodiment, the flat-panel PET detector is coaxial with the beam exit device and taken as a whole to perform neutron targeted irradiation in a horizontal posture. Others are the same as embodiment one.

[0043] The control method of the neutron beam guided by the flat PET of the system of embodiment one and embodiment two, such as Figure 5 shown, including the following steps:

[0044] 1) Synthesis of fluorine-18 labeled S-1-amino-1-phenylmethyl sodium trifluoroborate, with a mass of w 1 , the mass percent of boron-10 is ω B,1 A mixture of non-radioactive S-1-amino-1-phenylmethyl trifluoroborate sodium, calibrated for radioactivity A 0 , record this time as time 0; since the amount of radiolabeled S-1-amino-1-phenylmethyl sodium trifluoroborate is extremely small, it has little effect on the content of boron-10, so its quality can be considered as w 2 = 0; Boron-containing formulations were injected into irradiated samples.

[...

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Abstract

The invention discloses a panel PET-led boron neutron capturing therapeutic system and a neutron beam flow control method. Precise image information can be provided by utilizing a panel PET detector, and precise irradiation time information can be provided for BNCT (boron neutron capturing therapeutic system) so as to conduct the precision does delivery aiming at specific target area and reduce the irradiation damage of sensitive areas; the system can conduct neutron targeting irradiation under horizontal and vertical postures, and the distance away from a beam outlet device can be conveniently moved and adjusted by utilizing a motor control device; and the precise space alignment on movement of an irradiated sample can be conducted by utilizing a high-precision optical positioning and tracking system, so as to ensure the positioning accuracy of the target area.

Description

technical field [0001] The invention relates to positron emission tomography technology, in particular to a boron neutron capture therapy system and control method guided by flat-panel PET. Background technique [0002] Boron neutron capture therapy (BNCT) technology is a radiotherapy technology with broad prospects. This method has a long history, and there were preliminary attempts as early as the 1970s, and there are many application examples at present. However, due to the lack of effective neutron irradiation, radiation protection and other related technologies earlier, boron neutron capture therapy has not been widely used at present. In recent years, researchers from various countries have paid more and more attention to boron neutron capture therapy technology. With the development and maturity of various related technologies, boron neutron capture therapy technology is also developing rapidly. Now, there are many boron neutron capture therapy devices in operation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/03A61N5/10
CPCA61N5/10A61B6/037A61N2005/109Y02E30/30
Inventor 任秋实孟祥溪于泽宽
Owner PEKING UNIV
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