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Chinese medical extract atomizing dispersing process and preparation obtained through same

A technology of traditional Chinese medicine and extract, which is applied in the direction of making medicine into special physical or ingestible devices, powder transportation, etc., which can solve the problems of high energy consumption and long production cycle of dry powder of traditional Chinese medicine extract, and achieve energy saving, The effect of accelerating production efficiency

Inactive Publication Date: 2017-01-04
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the problems of high energy consumption and long production cycle in the preparation process of traditional Chinese medicine extract dry powder and improve production efficiency, it is necessary to provide a new production process for traditional Chinese medicine extract dry powder

Method used

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  • Chinese medical extract atomizing dispersing process and preparation obtained through same
  • Chinese medical extract atomizing dispersing process and preparation obtained through same
  • Chinese medical extract atomizing dispersing process and preparation obtained through same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 Preparation of Yangxue Xuenao Pill

[0067] 1.1 Preparation of Yangxue Xuenao extract

[0068] Get the following raw materials in parts by weight: 6.5 parts of Angelica sinensis, 6.5 parts of Rhizoma Chuanxiong, 5 parts of Radix Paeoniae Alba, 5 parts of Rehmannia glutinosa, 12.5 parts of Uncaria, 12.5 parts of Spatholobus, 12.5 parts of Prunella vulgaris, 12.5 parts of Semen Cassiae, and 12.5 parts of mother-of-pearl , Corydalis 6.5 parts, Asarum 1.25 parts.

[0069] Extract 1: Take Angelica, Rhizoma Chuanxiong, Corydalis Corydalis and Semen Cassiae in proportion, add 4 times the amount of 70% ethanol, heat and reflux to extract twice, the first time is 2 hours, the second time is 1 hour, filter, remove impurities, recover ethanol and concentrate to The relative density is 1.300~1.310 (74~76°C), that is.

[0070] Extraction 2: take Radix Paeoniae Alba in proportion, add 4 times the amount of 60% ethanol, impregnate, heat and reflux for extraction twice, the...

experiment example 1

[0083] Experimental Example 1 Detection of Beneficial Effect of Yangxue Xuenao Pill

[0084] The sample obtained by the method of Example 1 was subjected to a preliminary stability investigation for 3 months, and after three months of accelerated conditions, its quality was stable, and its properties, moisture, and dissolution time limit all met the product standard regulations, and the content of paeoniflorin and ferulic acid The detection data is stable (see attached figure 1 , 2 ).

[0085] After testing, the ferulic acid transfer rate of Yangxue Xuenao Pill obtained in the present invention is significantly improved, see Table 1:

[0086] Table 1

[0087] batch number 130701 130702 130703 130622 this invention original craft Theoretical content of ferulic acid 0.60mg / g 0.52mg / g 0.59mg / g 0.48mg / g 0.58mg / g 0.53mg / g Finished product content 0.43mg / g 0.44mg / g 0.42mg / g 0.26mg / g 0.39mg / g 0.17mg / g transfer rate 71.67％ ...

Embodiment 2

[0097] Example 2 Preparation of Nourishing Serum Brain Slices

[0098] 2.1 Preparation of Yangxue Xuenao extract

[0099] Same as 1.1.

[0100] 2.2 Preparation of brain dispersion of nourishing serum

[0101] Put the three extracts of nourishing blood brain into the slurry tank, heat to the material temperature of 70-80°C, and stir for 5 minutes to make the slurry. The slurry needs to be kept warm at 60-70°C during the preparation of the dispersion. Put the microcrystalline cellulose into the feeder of the granulator according to the ratio of 36:64 to the extract, and spray it into the slurry. The temperature of the bottom material is controlled at 40-60°C during the preparation process. After the slurry is sprayed out, cool down to 40°C. Below ℃, the material is discharged, and the dispersion of brain serum is obtained, and passed through a 16-mesh sieve.

[0102] 2.3 Tablet Preparation

[0103] The nourishing serum brain dispersion and the magnesium stearate are mixed ac...

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Abstract

The invention provides a preparation method of traditional Chinese medicine dispersion. The method includes the two steps of preparing pulp and preparing dispersible medicine. The invention further provides a method for preparing a blood-nourishing and brain-clearing preparation and other preparations through the method. In addition, the invention provides a preparation prepared through the method. The preparation prepared through the method has the advantages of being short in production period, saving energy consumption, improving production efficiency, being high in drug loading capacity and wide in drug loading range and the like, and the method can be universal for production and preparation of multiple varieties.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the field of traditional Chinese medicine preparations. Background technique [0002] Modern traditional Chinese medicine preparations, such as traditional Chinese medicine tablets, capsules, etc., are generally first extracted, separated, purified, and concentrated from Chinese medicinal materials to obtain liquid extracts or extracts, and sometimes further drying is required to obtain dry extracts, and then processed with auxiliary materials. Mixed and further prepared into various preparations. However, usually the production cycle is too long, and the active ingredients of traditional Chinese medicine will also be partially lost during the drying process. [0003] Pills, tablets, capsules, etc. are oral dosage forms often used in modern Chinese medicine, but usually in the process of preparation, the dry extract powder of the active ingredients of traditional Chi...

Claims

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Application Information

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IPC IPC(8): A61J3/00A61K9/14
Inventor 章顺楠白晓林李婷孙艳邵星云杨建会高松马永强董莉娜李磊马健伟姚凤娟
Owner TIANJIN TASLY PHARMA CO LTD
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