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Cytokine-like efficacy and cosmetic application of a nona-oligopeptide composition

A technology of composition and oligopeptide, which is applied in the direction of medical preparations containing active ingredients, preparations for grooming, skin care preparations, etc., can solve the problems of inconsistent content and different effects, and achieve skin repair and skin damage. The effect of perfect protection

Active Publication Date: 2019-04-16
珠海金肽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many research reports on this aspect, but due to the different substances used and inconsistent contents, the effects of the products on the skin are also different; therefore, further research is needed to explore the combination of oligopeptides that can comprehensively provide effective skin repair thing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Preparation of oligopeptide composition

[0050] Palmitoyl Tripeptide-1, 100ppm solution, 200mL

[0051] Tripeptide-1 copper, 500ppm solution, 20mL

[0052] Palmitoyl Tripeptide-5, 1000ppm solution, 10mL

[0053] Carnosine, Powder, 0.9g

[0054] Acetyl tetrapeptide-5, 1000ppm solution, 10mL

[0055] Palmitoyl tetrapeptide-7, 50ppm solution, 200mL

[0056] Acetyl Hexapeptide-8, 500ppm solution, 30mL

[0057] Nonapeptide-1, 100ppm solution, 30mL

[0058] Nisin, 0.18g.

[0059] According to the different solubility properties of the above oligopeptides, add water to prepare a 1000 mL solution.

[0060] Use the above solution as the mother liquor, and directly prepare it and add it to the acceptable base of cream, lotion or other beauty and skin care products; you can also add 10 grams of mannitol to the solution according to the freeze-vacuum drying method, according to 1~1.5 ml / vial Subpackaging, vacuum freeze-drying, capping (sealing), and making freeze-dried pow...

Embodiment 2

[0062] Anti-wrinkle, anti-wrinkle repair program for aging skin

[0063] After the routine beauty care procedures, disinfect the skin at the wrinkled area with 70% medical alcohol, add 1~3mL of normal saline to dissolve the freeze-dried powder prepared in Example 1, apply the mixture directly to the skin, and massage until Absorbs completely. It can also be introduced with commonly used instruments and methods in cosmetology and medical cosmetology, including ultrasonic equipment, iontophoresis or microneedles, hydrolight needles, lasers, injections, etc., to help the skin absorb and achieve the best skin repair effect.

Embodiment 3

[0065] Proliferation activity test of human skin fibroblasts

[0066] Material

[0067] The raw materials of Example 1 were made into 0.3-fold, 1.0-fold, and 3.0-fold oligopeptide compositions for later use, human skin fibroblasts (Dental Research Laboratory, Hokkaido University, Japan), α-MEM medium (GIBCO), fetal bovine serum ( GIBCO) penicillin streptomycin (Invitrogen), Trypan blue solution (Sigma), 0.25% Trypsin-1mM EDTA˙4Na (Invitrogen), IMSO (Sigma), cell number determination kit WST-8 (Japan) Infinite500 automatic enzyme labeling Instrument (Tecan).

[0068] Method and Results

[0069] Human skin fibroblasts in MEM medium (containing 5% fetal bovine serum), 5% CO 2 , 95% humidity, CO at 37°C 2 Cultivate in an incubator, change the medium once every 3 days, subculture the cells after 5-6 days of culture, suck out the original culture medium, wash twice with PBS, add 0.5mL of 0.25% Trypsin-1mM EDTA˙4Na solution, and store at 37°C After 30 seconds, add 10 mL of MEM m...

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PUM

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Abstract

The invention relates to the technical field of cosmetics, and discloses a nona-oligopeptide composition for skin repairing and application thereof. The nona-oligopeptide composition is prepared from, by weight, 1-30 parts of palmitoyl-tripeptide-1, 1-30 parts of tripeptide-1 copper, 1-50 parts of palmitoyl-tripeptide, 1-30 parts of carnosine, 1-30 parts of acetyl tetrapeptide-5, 1-30 parts of palmitoyl-tetrapeptide-7, 0.1-30 parts of acetyl hexapeptide-8, 0.1-30 parts of nonapeptide-1, and 1-30 parts of nisin. The nona-oligopeptide composition has the effect of a cell factor sample, affects the growth of skin flora, is applied to dermatology and skin beautifying, and has the effects of repairing skin lesion, adjusting metabolism and inhibiting skin condition conditioned pathogen growth.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to the cytokine-like efficacy and cosmetic application of a nona-oligopeptide composition. Background technique [0002] Peptides with smaller molecular weight, also known as small peptides, oligopeptides, oligopeptides, or small molecular active peptides, generally consist of several amino acids. Oligopeptides with smaller molecular weight can be directly absorbed by the skin. With the development of medicine, nutrition, skin science and molecular biology, oligopeptides are being studied more and more deeply. Scientists have discovered that oligopeptides have various biological activities on skin cells, and these biologically active substances are being revealed more and more. [0003] In recent years, a variety of cytokines have been used in skin damage repair and beauty products. He Zhenghong et al. (1999) invented a beauty composition (containing human fibroblast growth fact...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/06A61K8/92A61K8/891A61K8/81A61K8/67A61K8/60A61K8/41A61K8/37A61K8/34A61K8/31A61Q19/08A61Q19/00A61Q17/00
CPCA61K8/06A61K8/31A61K8/342A61K8/345A61K8/375A61K8/41A61K8/602A61K8/64A61K8/678A61K8/8147A61K8/891A61K8/922A61K2800/5922A61Q17/005A61Q19/00A61Q19/08
Inventor 周守山何俭林晓朱单单何政红
Owner 珠海金肽生物科技有限公司
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