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Novel Changkang tablets and preparation method thereof

A Changkang Tablet, a new type of technology, is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of inapplicability for patients, and achieve the goal of reducing discomfort and having safe and gentle ingredients. Effect

Inactive Publication Date: 2017-01-04
HUNAN KANGERJIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that Changkang Tablets are made by combining the above three main functional ingredients. It mainly achieves the purpose of antidiarrheal by removing damp heat and sterilizing bacteria. However, its medicinal effect is relatively strong, and it is extremely unsuitable for patients with other complications, such as Patients with chronic diseases such as hypertension, heart disease, liver disease, kidney disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Berberine hydrochloride, wood incense, Evodia rutaecarpa, sodium carboxymethylcellulose and chitosan were all crushed into 400-mesh powder in advance, and 156.5g of wood fragrance and 125g of Evodia rutaecarpa were decocted twice, each time for 2 hours, The decoctions were combined and filtered, the filtrate was allowed to stand for 24 hours, and the supernatant was concentrated to a clear paste with a relative density of 1.18-1.20 at 70°C;

[0023] Premix 50g of berberine hydrochloride with 156.5g of woody incense, add clear paste to granulate, dry into granules, add 2g of honey and stir evenly, then add 30g of carboxymethylcellulose sodium and 10g of deacetylation degree to 70%, Chitosan with a molecular weight of 80,000 was evenly mixed, pressed into 1000 tablets, placed in an environment with a relative humidity of 80% for 5 minutes, and then dried at 50° C. to obtain the product.

Embodiment 2

[0025] Berberine hydrochloride, woody incense, Evodia rutaecarpa, sodium carboxymethylcellulose and chitosan were all crushed into 200-mesh powder in advance, and 150g of woody wood and 130g of Evodia rutaecarpa were decocted twice, each time for 2 hours, combined Filter the decoction, let the filtrate stand for 24 hours, and concentrate the supernatant to a clear paste with a relative density of 1.18-1.20 at 70°C;

[0026] 45g of berberine hydrochloride and 150g of woody incense are premixed, add clear paste and granulate, dry into granules, add 35g of sodium carboxymethylcellulose and 8g of chitosan with a degree of deacetylation of 80% and a molecular weight of 90,000 and mix evenly. Press into 1000 tablets, place the tablets in an environment with a relative humidity of 70% for 10 minutes, and then dry at 55° C. to obtain the product.

Embodiment 3

[0028] Berberine hydrochloride, wood incense, Evodia rutaecarpa, sodium carboxymethylcellulose and chitosan were all ground into 300-mesh powder in advance, and 170g of wood fragrance and 110g of Evodia rutaecarpa were decocted twice, each time for 2 hours, combined Filter the decoction, let the filtrate stand for 24 hours, and concentrate the supernatant to a clear paste with a relative density of 1.18-1.20 at 70°C;

[0029] 60g of berberine hydrochloride and 170g of woody incense are premixed, add clear paste to granulate, dry into granules, add 20g of sodium carboxymethylcellulose and 14g of chitosan with a degree of deacetylation of 70% and a molecular weight of 100,000 and mix evenly. Press into 1000 tablets, place the tablets in an environment with a relative humidity of 80% for 6 minutes, and then dry at 60° C. to obtain the product.

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PUM

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Abstract

The invention relates to novel Changkang tablets and a preparation method thereof. The novel Changkang tablets are prepared from, by weight, 40-60 parts of berberine hydrochloride, 280-340 parts of radix aucklandiae, 110-140 parts of processed fructus evodiae, 20-30 parts of sodium carboxymethylcellulose and 6-14 parts of chitosan. Components of the novel Changkang tablets are safe and mild; by addition of carboxymethyl cellulose and chitosan, slow release and long action can be realized while intestinal wall protection can be achieved, discomfort caused by strong action of the tablets can be reduced for patients, and the novel Changkang tablets are suitable for patients suffering from complications and chronic diseases such as hypertension, heart diseases, diabetes, hepatopathy and nephropathy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a novel Changkang tablet and a preparation method thereof. Background technique [0002] Changkang tablets are one of the commonly used medicines for damp-heat diarrhea, because it has the functions of clearing away heat and dampness, regulating qi and relieving pain. In the prior art, Changkang Tablets are mainly prepared from the three active ingredients of berberine hydrochloride, woody fragrance and evodia rutaecarpa, and then mixed with auxiliary tableting agents and flavoring agents such as talcum powder, magnesium stearate and sucrose. Among them, berberine hydrochloride (also known as berberine hydrochloride) has inhibitory effect on Shigella, Escherichia coli, pneumococcus, Staphylococcus aureus, streptococcus, typhoid bacillus and amoeba, and is mainly used clinically for intestinal infection and bacterial infection. Dysentery, etc.; Muxiang (al...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/26A61K36/754A61P1/12A61K31/4375A61K31/7004
CPCA61K9/0002A61K9/2018A61K9/205A61K9/2054A61K31/4375A61K31/7004A61K36/285A61K36/754A61K2300/00
Inventor 江华聂惠君彭舒怀
Owner HUNAN KANGERJIA PHARMA
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