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Target delivery system based on bio-functionalized nano-silver loaded taxol or analogue thereof

A biofunctionalization and delivery system technology, applied in the field of targeted delivery system and its preparation, can solve the problems of toxic side effects of healthy organs, low solubility, multi-drug resistance of tumors, etc.

Inactive Publication Date: 2017-01-04
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the existing anti-tumor drugs generally have three major problems: serious side effects on healthy organs, multi-drug resistance of tumors and low solubility.

Method used

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  • Target delivery system based on bio-functionalized nano-silver loaded taxol or analogue thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Combining antineoplastic drugs with paclitaxel and nano silver at a molar ratio of 1:0.01, paclitaxel and nano silver are administered in a targeted system as a joint component; combined antineoplastic drugs and methoxypolyethylene glycol-polylactic acid amphiphile Sexual block copolymer (MPEG-PLA) by weight percentage 1:5, methoxy polyethylene glycol-polylactic acid amphiphilic block copolymer (MPEG-PLA) and MUC1 nucleic acid aptamer by weight percentage 1:0.5 , the paclitaxel nanosilver targeted delivery system was obtained by the following steps:

[0053] (1) Bonding of MUC1 nucleic acid aptamer to methoxypolyethylene glycol-polylactic acid amphiphilic block copolymer (MPEG-PLA): nucleic acid aptamer and high molecular polymer use excess 1-ethyl -3-(3-Dimethylaminopropyl) carbodiimide (EDC) and NHS were incubated at room temperature to obtain NHS activated bonds to obtain the MUC1 nucleic acid aptamer-MPEG-PLA, namely (MPEG-PLA-Apt);

[0054] (2) Weighing MPEG-PLA-A...

Embodiment 2

[0057] Tetrahydropaclitaxel and nano-silver are used as a combined anti-tumor drug in a weight percentage of 1:0.5, and tetrahydro-paclitaxel and nano-silver are administered through a targeted delivery system; combined anti-cancer drugs and polylactide-glycolide-polyethylene glycol Alcohol-polylactide-glycolide block copolymer (PLGA-PEG-PLGA) by weight percentage 1:25, polylactide-glycolide-polyethylene glycol-polylactide-glycolide block copolymer (PLGA-PEG-PLGA) and MUC1 nucleic acid aptamer by weight percentage 1:20, the tetrahydropaclitaxel nano silver targeted delivery system was obtained by the following steps:

[0058] (1) Bonding of SZTI01 nucleic acid aptamer to polylactide-glycolide-polyethylene glycol-polylactide-glycolide block copolymer (PLGA-PEG-PLGA): SZTI01 nucleic acid aptamer and The polymer was incubated with excess 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and NHS at room temperature to obtain NHS activated bonding to obtain SZTI01 nucleic acid a...

Embodiment 3

[0062] Using hexahydropaclitaxel and nano-silver as a combined anti-tumor drug in a weight percentage of 1:0.25, hexahydro-paclitaxel and nano-silver are administered through a targeted delivery system; the combined anti-cancer drug is combined with polyethylene glycol-polylactide-glycolide Ester-polyethylene glycol block copolymer (PEG-PLGA-PEG) by weight percentage 1:30, polyethylene glycol-polylactide-glycolide-polyethylene glycol block copolymer (PEG-PLGA- PEG) and A10 nucleic acid aptamer by weight percentage 1:15, obtain hexahydropaclitaxel nano-silver targeted delivery system through the following steps:

[0063] (1) Bonding of A10 nucleic acid aptamer to polyethylene glycol-polylactide-glycolide-polyethylene glycol block copolymer (PEG-PLGA-PEG): A10 nucleic acid aptamer and polymer polymerization The substance was incubated with excess 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and NHS at room temperature to obtain NHS activated bonding to obtain A10 nucleic...

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Abstract

The invention relates to the technical field of bio-medicines, and particularly relates to a target delivery system based on bio-functionalized nano-silver loaded taxol or analogue thereof. The target delivery system comprises an anti-tumor medicine composition, a target ligand and a bio-degradable high-molecular polymer, wherein the anti-tumor medicine composition is prepared from nano-silver and taxol or analogue thereof. The target delivery system can selectively reach a tumor position to improve the treatment effect and reduce toxic or side effect, and can be used for effectively treating cancers.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a targeted delivery system based on biologically functionalized nano-silver loading paclitaxel or its analogues and its preparation method and application. Background technique [0002] Cancer has become the leading cause of death and a major public health problem, among which the incidence and mortality of lung cancer rank first. Over the past few decades, cancer has transformed from an "incurable disease" to one with "increasing chemotherapy regimens and personalized treatment options." However, the current chemotherapy as the main treatment for cancer is not ideal, and there are problems of low activity, serious side effects and multi-drug resistance of tumors. Finding more effective treatments is one of the current research hotspots. [0003] Since the discovery of cisplatin's anticancer activity in the late 1960s, metal complexes have attracted widespread attention, an...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/48A61K47/34A61K47/36A61K33/38A61P35/00A61K31/337
CPCA61K33/38A61K9/5146A61K9/5161A61K31/337A61K2300/00
Inventor 何燕武文敬张焜程书朋江森马诗经郑希杜志云霍延平方岩雄
Owner GUANGDONG UNIV OF TECH
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