Colistin sulfate and berberine hydrochloride composition and preparation method of pellets of colistin sulfate and berberine hydrochloride composition

Abstract

The invention relates to a colistin sulfate and berberine hydrochloride composition and a preparation method of pellets of the colistin sulfate and berberine hydrochloride composition and aims to solve the problems that the effect of treating escherichia coli and salmonella infection by using the colistin sulfate is poor due to poor intestinal absorption in the prior art, and the use dosage is required to be increased for reaching an ideal treatment effect. The preparation method comprises the following steps: firstly, mixing the colistin sulfate, the berberine hydrochloride, a filling agent, a lubricating agent and a disintegrating agent; secondly, crushing to obtain mixture powder; adding a binding agent to obtain pellets; coating to obtain the pellets of the colistin sulfate and berberine hydrochloride composition. The pellets of the colistin sulfate and berberine hydrochloride composition, obtained by the preparation method disclosed by the invention, are prepared by adopting conventional equipment such as a granulating device and a coating device in the pharmaceutical industry; the preparation method can realize continuous production and is suitable for industrial production; high yield is realized.

Description

technical field [0001] The invention relates to a composition of colistin sulfate and berberine hydrochloride and a method for preparing pellets thereof, belonging to the technical field of veterinary drug preparation. Background technique [0002] Colistin sulfate has a strong adsorption effect on the cell membrane of sensitive bacteria. The positively charged free amino group in the drug molecule can combine with the negatively charged free phosphate in the cell membrane phospholipid, which reduces the surface tension and increases the permeability of the cell membrane, resulting in Depolymerization causes the leakage of amino acids, purine, pyrimidine and inorganic salts in the bacteria, leading to the death of bacteria; while the mechanism of action of berberine hydrochloride is to inhibit the synthesis of bacterial DNA and play an antibacterial effect, colistin sulfate and berberine hydrochloride The targets are different, and the antibacterial effect can be improved by...

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Problems solved by technology

[0003] The invention provides a colistin sulfate and berberine hydrochloride composition and a method for preparing pellets thereof, which solves the problem in the prior art that colistin sulfate is used to treat Escherichia coli and Salmonella infections due to poor gastrointestinal absorption and poor therapeutic effect And do not increase the dosage to overcome the problem of poor therapeutic effect

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