Bibenzyl compound, preparation method thereof, and application thereof in preparation of antitumor medicines
A compound and tumor technology, applied in the fields of anti-tumor drugs, ether preparation, drug combination, etc., can solve the problems such as no bibenzyl compound anti-tumor drug research reports.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0115] Example 1, the extraction and structural identification of compound F
[0116] (1) Extraction of medicinal materials:
[0117] Dried white and medicinal material coarse powder (3kg), reflux extraction with 95% ethanol 3 times (30L×3), 2h each time;
[0118] (2) Separation and purification of components:
[0119] 1. Ethanol extract (90L) was concentrated and dried under reduced pressure to obtain 510g of semi-solid liquid extract;
[0120] ②. Disperse the semi-solid liquid extract (500g) with water (5L), extract with ethyl acetate and n-butanol (20L) successively, combine the ethyl acetate part, recover the solvent under reduced pressure, and obtain 160g of ethyl acetate extract;
[0121] 3. Adopt silica gel column chromatography to separate ethyl acetate extract (160g), petroleum ether: acetone carries out gradient elution, and the eluent is detected by thin-layer chromatography, and obtains the elution when petroleum ether: acetone=30:1 Liquid Fr.16;
[0122] The c...
Embodiment 2
[0136] Example 2, the extraction and structural identification of compound G
[0137] (1) Extraction of medicinal materials:
[0138] Dried white and medicinal material coarse powder (3kg), reflux extraction with 95% ethanol 3 times (30L×3), 2h each time;
[0139] (2) Separation and purification of components:
[0140] 1. Ethanol extract (90L) was concentrated and dried under reduced pressure to obtain 510g of semi-solid liquid extract;
[0141] ②. Disperse the semi-solid liquid extract (500g) with water (5L), extract with ethyl acetate and n-butanol (20L) successively, combine the ethyl acetate part, recover the solvent under reduced pressure, and obtain 160g of ethyl acetate extract;
[0142] 3. Adopt silica gel column chromatography to separate ethyl acetate extract (160g), petroleum ether: acetone carries out gradient elution, and the eluent is detected by thin-layer chromatography, and obtains the elution when petroleum ether: acetone=30:1 Liquid Fr.16;
[0143] The c...
Embodiment 3
[0156] Example 3, the extraction and structural identification of compound H
[0157] (1) Extraction of medicinal materials:
[0158] Dried white and medicinal material coarse powder (3kg), reflux extraction with 95% ethanol 3 times (30L×3), 2h each time;
[0159] (2) Separation and purification of components:
[0160]1. Ethanol extract (90L) was concentrated and dried under reduced pressure to obtain 510g of semi-solid liquid extract;
[0161] ②. Disperse the semi-solid liquid extract (500g) with water (5L), extract with ethyl acetate and n-butanol (20L) successively, combine the ethyl acetate part, recover the solvent under reduced pressure, and obtain 160g of ethyl acetate extract;
[0162] 3. Adopt silica gel column chromatography to separate ethyl acetate extract (160g), petroleum ether: acetone carries out gradient elution, and the eluent is detected by thin-layer chromatography, and obtains the elution when petroleum ether: acetone=30:1 Liquid Fr.16;
[0163] The co...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com