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Pharmaceutical composition for relieving emesis and inhibiting cancer as well as preparation method and application of pharmaceutical composition

A composition and drug technology, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as strong toxic and side effects, affecting the overall efficacy of tumor treatment, and application limitations.

Inactive Publication Date: 2017-02-08
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A small number of patients also discontinue or refuse further treatment due to unbearable treatment-related side effects, which affects the overall efficacy of cancer treatment
[0003] At present, the antiemetics commonly used in clinical practice mainly include: thiazide drugs, antihistamines, anticholinergic drugs, as well as metoclopramide (metoclopramide), domperidone (morphine), antiemetic, Chlorbutanol, etc., but these drugs have poor therapeutic effect on vomiting after chemotherapy and radiotherapy, and have strong toxic and side effects, so their application is greatly limited
New antiemetic drugs, such as 5-HT3 receptor antagonists, are effective in antiemetic effects after chemotherapy and radiotherapy, but they are expensive and have high toxicity and side effects. Clinically, they often need to be used in combination, and there is no anticancer effect Therefore, the development of natural anticancer drugs is expected

Method used

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  • Pharmaceutical composition for relieving emesis and inhibiting cancer as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition for relieving emesis and inhibiting cancer as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition for relieving emesis and inhibiting cancer as well as preparation method and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0042] Preparation of pharmaceutical composition capsule formulation

[0043] Curcumin preparation: the turmeric tubers are washed with water, dried naturally, ground into powder with a high-speed universal pulverizer, and passed through a 40-mesh sieve. Put the sieved fine powder into about 5000mL large grinding mouth bottle, soak about 12h at room temperature with about 10 times the amount of 95% edible ethanol, extract about 75min by ultrasonic at about 50°C and about 40KHz ultrasonic frequency, heat and reflux for about 1.5 h, filter the reflux liquid, pass through a rotary evaporator, speed: about 80-100rpm; temperature: about 65-70°C; vacuum degree: about 300-350Pa, vacuum concentrate to obtain a ginger-like mixture, and then concentrate and dry the mixture several times Purify to obtain curcumin preparation.

[0044] Euonymus fresh ginger and turmeric decoction concentrated extract: According to the compatibility ratio of about 20:3:2 Euonymus dried pulverized matter, ...

experiment example 1

[0048] Experimental Example 1: Pharmacodynamic study of the effect of the pharmaceutical composition on emesis

[0049] 1. Experimental materials

[0050] (1) Euonymus, purchased from Qingdao Zhongsheng Pharmacy, and identified by Professor Zhang Yanzhi of Shandong Linyi Medical College. Ginger, purchased in Qingdao, Shandong, was identified as the tuber of Zingiberaceae Zingiberaceae by Professor Zhang Yanzhi of Shandong Linyi Medical College. Turmeric was purchased from Qingdao Zhongsheng Pharmacy and identified by Professor Zhang Yanzhi of Shandong Linyi Medical College.

[0051] (2) Cisplatin (cisplatin), produced by Shandong Qilu Pharmaceutical Factory, batch number: 05070122, 20mg / bottle.

[0052] (3) Ondansetron hydrochloride injection (Qilu Pharmaceutical Co., Ltd., batch number 200503003, 2ml 4 mg.

[0053] (4) Kaolin, Shanghai Fengxian Fengcheng Trial Factory, batch number: 050528. The kaolin feed is prepared by mixing kaolin with 1% gum arabic and distilled wa...

experiment example 2

[0067] Experimental Example 2: Pharmacodynamic study of the antitumor effect of the pharmaceutical composition of the present invention

[0068] Experimental Materials

[0069] (1) Kunming mice, weighing 20±2 g, provided by the Experimental Animal Center of Qingdao Institute for Drug Control.

[0070] Free to eat and drink before the experiment, 24h natural light exposure.

[0071] (2) Cyclophosphamide, a product of Jiangsu Hengrui Pharmaceutical Co., Ltd.

[0072] Experimental method: for mice S 180 Sarcoma Growth Inhibition Experiment

[0073] Use the milky white ascites that has grown well for 5-7 days, and dilute the tumor cell suspension with an appropriate amount of sterile saline, and the number of cells is 10 7 / mL, 12 rats in each group, subcutaneously inoculate 0.2mL (containing tumor cells 2×10 6 indivual). Inoculate random grouping the next day, experimental group is divided into (400,200,100mg / mL) three dosage groups of pharmaceutical composition of the pres...

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Abstract

The invention provides a pharmaceutical composition for relieving emesis and inhibiting cancer as well as a preparation method and application of the pharmaceutical composition, and belongs to the technical field of Chinese herbal medicinal preparations. The pharmaceutical composition is prepared from 3 to 8 weight parts of winged euonymus, fresh ginger and rhizoma curcumae longae water decocted and concentrated extract, 2 to 3 weight parts of curcumin preparing product, 2 to 4 weight parts of gingerol prepared product and 1 to 2 weight parts of winged euonymus and ethanol extract. The pharmaceutical composition provided by the invention has a good effect of relieving the emesis and inhibiting the cancer.

Description

technical field [0001] The invention belongs to the technical field of Chinese herbal medicine preparations, and in particular relates to a pharmaceutical composition for relieving vomiting and suppressing cancer. The invention also relates to a preparation method of the pharmaceutical composition, and the preparation of the pharmaceutical composition for relieving vomiting and cancer caused by cancer chemotherapy. Use in anticancer drugs. Background technique [0002] In recent years, the number of cancer patients and deaths worldwide has been increasing disturbingly. Nearly half of the new cancer cases occurred in Asia, most of which were in China, which ranked first in the number of new cancer cases. There are 1.8 million malignant tumor patients in my country every year, and 2 / 3 of them receive radiotherapy and chemotherapy. Although it is effective, it will also bring relatively large side effects to patients. The most common side effects are gastrointestinal reactions ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/08A61P35/00A61K9/48A61K31/12A61K31/122
CPCA61K36/37A61K9/4866A61K31/12A61K31/122A61K36/9066A61K36/9068A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 徐珞孙向荣郭菲菲徐然张小千
Owner QINGDAO UNIV
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