High temperature and high pressure automatic chemical reaction system

Abstract

A high-temperature and high-pressure fully automatic chemical reaction system, including a closed main circulation loop, on which a high-pressure liquid phase circulation pump is used to drive the circulation of the reaction mixture in the main circulation loop; a detector is used to monitor the circulation The chemical reaction process in the main loop; the pressure regulator is used to adjust the pressure in the main circulation loop; the switching valve is connected in the main circulation loop and is used for the input and output of materials. The switching valve includes the first switching valve and the second switching valve. Switching valve; exhaust valve, connected to the circulation main circuit, for gas discharge; reagent introduction device, used to provide reaction reagents, the reagent introduction device includes a reaction mixing mechanism, the reaction mixing mechanism is connected to the circulation main circuit through the first switching valve Middle: The product collection device is connected to the main circulation loop through the second switching valve, and is located between the input port of the high-pressure liquid phase circulating pump and the output port of the reaction mixing mechanism. The reaction system of the invention has high controllability and can be directly enlarged.

Description

technical field [0001] The invention relates to the technical field of chemical reactors, in particular to a high-temperature and high-pressure fully automatic chemical reaction system. Background technique [0002] Chemical reaction is a process in which reactant molecules collide with each other to produce structural reorganization. Therefore, heating, pressure and stirring are required during the reaction process to make the molecular movement violent and the distance closer, so as to speed up the reaction and reach chemical equilibrium as soon as possible. When the reaction reaches chemical equilibrium, it reaches the end point. [0003] At present, chemical reactions are carried out in open, reflux or closed reaction vessels. The reaction conditions of open and reflux reaction devices can only be normal pressure, and the temperature can reach up to 100~200 o C, and generally requires professionals to wait and pay attention. Under the condition of low temperature and ...

AI Technical Summary

Problems solved by technology

The speed of this reaction system has been accelerated, but the closed system is not suitable for the reaction of generating gas, because if the product gas cannot be released from the reaction system, the reaction will not be complete, and the yield when reaching chemical equilibrium is correspondingly low

[0004] Furthermore, most chemical reactions must be homogeneous reactions under liquid phase conditions, otherwise the reaction will be difficult to carry out, and it will take a long time to obtain the product, which cannot be used for chemical synthesis

In order for the chemical reaction to react in a liquid-phase homogeneous condition, the reactants must be dissolved, but many reactants must be dissolved in a highly toxic or expensive solution, causing many problems such as safety, environmental protection, and cost.

[0005] In addition, in the synthesis process of drug development, the amount of compound required for initial drug screening is very small, and the reaction in milligrams can meet the requirements. After the screening determines the efficacy and bioavailability, the selected compound can enter preclinical experiments. At this time, the synthesis amount must reach the kilogram level, and there must be a definite synthesis process before the preclinical experiment is carried out, otherwise the experimental data cannot be used as an application for clinical approval

Therefore, the initial small-scale synthesis must go through pilot-scale scale-up research. This process is very time-consuming and often costs millions or millions, which not only delays the drug development process but also increases development costs.

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