A method for extracting low-phosphorus oxytetracycline finished product from oxytetracycline fermentation liquid

Abstract

The invention discloses a method for extracting a low-phosphorus-content oxytetracycline finished product from an oxytetracycline fermentation broth and relates to the technical field of oxytetracycline production. The method comprises the steps of a, preparing the purified water, wherein the indexes of the purified water are as follows: the pollution index SDI thereof smaller than or equal to 4, the residual chlorine thereof smaller than or equal to 0.1 mg / L and the conductivity thereof smaller than 1.1 us / cm at the temperature of 25 DEG C; storing the prepared purified water in a purified water storage tank for later use; b, preparing a fermentation diluent; c, processing filter materials; d, conducting the decoloration treatment; e, extracting an oxytetracycline wet crystal; f, dephosphorizing the oxytetracycline wet crystal, and washing the oxytetracycline wet crystal in a separated plate frame by using the purified water stored in the purified water storage tank through a circulation loop by means of a circulation pump, so as to fully dissolving phosphorus impurities in the wet crystal in the purified water, wherein the phosphorus impurities are carried away by the circulated purified water and the effect of removing phosphorus impurities is realized; h, drying the oxytetracycline wet crystal to obtain the oxytetracycline finished product. According to the invention, phosphorus impurities in the oxytetracycline finished product can be effectively removed.

Description

technical field [0001] The invention relates to the technical field of oxytetracycline production. Background technique [0002] The production process of oxytetracycline is to cultivate Streptomyces fischisus through Streptomyces fischisus culture medium, so that Streptomyces fischisus can proliferate in large numbers, prompting it to produce oxytetracycline in the process of biological metabolism, and form soil after the fermentation process is over. Oxytetracycline fermentation broth, oxytetracycline exists in the cells of Streptomyces fissures in the oxytetracycline fermentation broth, and then oxytetracycline is extracted from the oxytetracycline fermentation broth, because the culture medium of Streptomyces fissures contains Streptomyces fissures Phosphorus, the nutrient component of oxytetracycline, is high in phosphorus content in finished oxytetracycline prepared by conventional production technology. The phosphorus content is 25ppm-30ppm as detected by EN ISO17294-...

AI Technical Summary

Problems solved by technology

If the amount of oxytetracycline filtrate treated by resin is reduced, the phosphorus content in the decolorization solution will be reduced, but at the same time the resin adsorbs a large amount of oxytetracycline, resulting in a decline in yield

[0006] At present, although the phosphorus content in the finished product of oxytetracycline can be reduced through the above methods, the phosphorus content in the finished product is extremely unstable and cannot reach the state of passing the batch inspection, and will cause a substantial increase in production costs