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Application and synthesis method of copper-containing photo-thermal nano material

A technology of nanomaterials and synthesis methods, applied in the fields of nanomaterials and nanomedicine, to achieve the effects of simple preparation methods, easy storage, and convenient purification

Active Publication Date: 2017-02-15
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no easy way to use carbon dots to prepare photothermal materials or improve the performance of photothermal materials

Method used

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  • Application and synthesis method of copper-containing photo-thermal nano material
  • Application and synthesis method of copper-containing photo-thermal nano material
  • Application and synthesis method of copper-containing photo-thermal nano material

Examples

Experimental program
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preparation example Construction

[0033] In step 3, the preparation method of copper-containing photothermal nanomaterials specifically includes the following steps:

[0034] (1) rapidly mixing the synthesized fluorescent carbon dots with the copper salt solution;

[0035] (2) Stirring or static reaction at 20-80°C for 0.5-6 hours;

[0036] (3) After the obtained copper-containing photothermal nanomaterial is centrifuged or dialyzed in a dialysis bag, a pure copper-containing photothermal nanomaterial aqueous solution is obtained;

[0037] (4) Adding a stabilizer to the aqueous solution of copper-containing photothermal nanomaterials for surface modification, stirring and reacting at room temperature overnight;

[0038] (5) After the reaction solution is centrifuged or dialyzed in a dialysis bag, a pure and stable copper-containing photothermal nanomaterial is obtained.

[0039] In the above embodiments, the copper-containing salt solution may be a copper sulfate solution, a copper chloride solution, or a co...

Embodiment 1

[0042] The preparation method of novel fluorescent carbon point (see figure 1 ), including the following steps:

[0043] (1) Dissolve 672mg of L-cysteine ​​and 300mg of o-phenylenediamine in ultrapure water, and add a certain amount of sodium hydroxide solution to completely dissolve L-cysteine.

[0044] (2) After mixing the two solutions, set the volume to 30mL and transfer to a 50mL hydrothermal reaction kettle.

[0045] (3) React in 160°C water heat for 10h, and after cooling down to room temperature, an aqueous solution of carbon dots is prepared. The obtained carbon dots have a particle size of about 3.4nm (see Figure 2).

Embodiment 2

[0047]Two sub-experiments were included, and sub-experiment 1 was similar to Example 1, 672 mg of L-cysteine ​​was replaced with 67.2 mg of L-cysteine. In sub-experiment 2, the amount of o-phenylenediamine was changed to 30 mg while keeping the amount of L-cysteine ​​unchanged.

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Abstract

The invention belongs to the field of nano materials and biomedicines and discloses application and a synthesis method of a copper-containing photo-thermal nano material. O-phenylenediamine and L-cysteine are adopted as raw materials for one-step preparation of fluorescent carbon dots high in stability and water solubility by means of hydro-thermal synthesis, and the carbon dots and copper-containing salt solution are simply mixed to obtain the copper-containing photo-thermal nano material excellent in photo-thermal performance. The invention further provides a method for improving stability of the copper-containing photo-thermal nano material by surface modification.

Description

technical field [0001] The invention belongs to the field of nanomaterials and nanomedicine, and in particular relates to the preparation and stable modification method of a copper-containing nanosheet photothermal material synthesized by novel fluorescent carbon dots and its biomedical application. Background technique [0002] In recent years, photothermal therapy has attracted increasing attention as an effective approach to treat cancer. Photothermal therapy is considered to be a minimally invasive tumor treatment method that can replace targeted therapy without causing systemic effects. Since near-infrared light is not easily absorbed by the skin and tissues, and has strong tissue penetration ability, the use of near-infrared light to irradiate the tissue injected with photothermal reagents can effectively kill cancer cells by using photothermal conversion. At present, the photothermal materials reported in the literature are mainly divided into the following four cate...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/00A61P35/00
CPCA61K41/0052A61K49/0019A61K49/005
Inventor 吴富根鲍琰雯华先武
Owner SOUTHEAST UNIV
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