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Compound vitamin injection and preparation method thereof

A technology for multivitamins and injections, applied in the directions of drug combinations, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc., can solve the problems of increased cost, complicated process, complicated production process, etc., and achieves low production cost and simple preparation process. Effect

Inactive Publication Date: 2017-02-22
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems of its stability and solubility, freeze-drying method is used in many processes to prepare it into freeze-dried powder injection, which is then dissolved in water for injection before use. However, freeze-drying is not only complicated in process, but also The equipment is expensive, the energy consumption is high, and the freeze-dried powder produced has disadvantages such as poor reconstitution effect
In the Chinese invention patent CN101433547, glycine is used as filler, glycocholic acid and lecithin are used as solubilizers to make a multivitamin aqueous solution containing 12 kinds of vitamins, and then freeze-dried to make injection powder. The production process is complicated and inconvenient to use.
In addition, Chinese invention patents CN101181289A, CN101073580, CN100361659, etc. also disclose a series of multivitamin injection preparations, but most of these are packaged in separate bottles according to their physical and chemical properties, which increases the production cost virtually. , and it is more inconvenient to use

Method used

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  • Compound vitamin injection and preparation method thereof
  • Compound vitamin injection and preparation method thereof
  • Compound vitamin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prescription composition (contained per 1mL)

[0031]

[0032] Preparation:

[0033] 1) Weigh the prescribed amount of vitamin A palmitate and Tween 80, stir evenly at a constant temperature of 50-60°C, add the prescribed amount of vitamin E and vitamin D3 and continue stirring evenly, then add 50% of the prescribed amount of fresh injection Water to obtain a clear aqueous solution of fat-soluble vitamins, set aside.

[0034] 2) Dissolving the remaining water-soluble vitamin components and optional medically acceptable auxiliary materials in the remaining amount of fresh water for injection, respectively or together, and adjusting the pH to 5.5-6.5 to obtain a water-soluble vitamin aqueous solution, which is ready for use.

[0035] 3) Combine the solutions of steps 1) and 2), add 0.03% (g / mL) activated carbon, stir, filter to remove the activated carbon, filter through a 0.22 μm microporous membrane, filter and sterilize, and fill. An orange-red clear and transpare...

Embodiment 2

[0037] Prescription composition (contained per 1mL)

[0038]

[0039] The preparation method is the same as in Example 1.

Embodiment 3

[0041] The composition of the prescription is the same as in Example 1.

[0042] Preparation:

[0043] 1) First dissolve vitamin D3 in 1,2-propanediol to make a solution of 40,000 IU / mL for later use;

[0044] 2) Take the prescribed amount of vitamin A palmitate and Tween 80 and stir evenly at a constant temperature of 50-60°C, then add the prescribed amount of vitamin E and vitamin D3 in 1,2-propanediol solution, continue to stir evenly, Add fresh water for injection of 50% of the prescribed amount to obtain a clear aqueous solution of fat-soluble vitamins, which is set aside.

[0045] 3) Dissolving the remaining water-soluble vitamin components and optional medically acceptable auxiliary materials in the remaining amount of fresh water for injection, respectively or together, and adjusting the pH to 5.5-6.5 to obtain a water-soluble vitamin aqueous solution, which is ready for use.

[0046] 4) Combine the solutions of steps 2) and 3), add 0.03% (g / mL) activated carbon, stir,...

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Abstract

The invention relates to a compound vitamin injection and a preparation method of the compound vitamin injection. The injection comprises both fat-soluble vitamins and water-soluble vitamins, and the appearance of the injection is in the state of a clear and transparent solution, wherein the injection further comprises appropriate amounts of solubilizers, antioxidants, cosolvents, complexing agents and water for injection, the preparation method of the compound vitamin injection particularly comprises the following steps: uniformly mixing the fat-soluble vitamins with solubilizers firstly, then adding a part of fresh water for injection to be dissolved so as to obtain a clear and transparent solution A, adding the residual amount of fresh water for injection in the remaining water-soluble vitamins, the antioxidants, the complexing agents and the like to be stirred and dissolved completely to obtain a solution B, then mixing the solution A with the solution B, adding activated carbon to be stirred, roughly filtering, and then filtering and carrying out sterilization, and filling and sealing; compared with the prior art, the compound vitamin injection and the preparation method of the compound vitamin injection are relatively lower in production cost, and further simple in adopted preparation technological process, and do not require special equipments, thereby being very suitable for industrialized mass production.

Description

[0001] [technical field] [0002] The invention belongs to the field of veterinary pharmaceutical preparations, in particular to a compound vitamin injection containing fat-soluble and water-soluble vitamins and a preparation method thereof. [0003] [Background technique] [0004] Vitamins play an important role in the growth, metabolism, and development of humans and animals. They are a kind of ingredients necessary to maintain life activities and important active substances to maintain health. The content of vitamins in the body is very small. They are neither the raw materials of the tissues nor the substances of energy supply, but for humans and animals, they are indispensable nutrients for maintaining the normal life activities of the body. Vitamins are not simply a substance, but a general term for a large class of substances. Up to now, people have discovered 27 kinds of vitamins. Most of them cannot be synthesized by the body or the amount of synthesis cannot meet the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/07A61K31/593A61K31/355A61K31/51A61K31/4415A61K31/164A61K31/675A61K31/455A61K9/08A61K47/26A61K47/10A61K47/32A61P3/02
CPCA61K47/10A61K47/26A61K9/0019A61K9/08A61K31/07A61K31/164A61K31/355A61K31/4415A61K31/455A61K31/51A61K31/593A61K31/675A61K31/714A61K2300/00
Inventor 林文辉吴范宏樊冬丽郭玲玲顾岳明何引花廖雪玲
Owner SHANGHAI INST OF TECH