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Western medicine composition for treating xerophthalmia and preparation method thereof

A dry eye disease and Western medicine technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as poor taste, increased economic pressure, and complications, and achieve simple preparation methods and reduce economic pressure , the effect of low production cost

Inactive Publication Date: 2017-02-22
ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are three kinds of treatment methods for dry eye disease: traditional Chinese medicine, western medicine and surgical treatment. The treatment cycle of traditional Chinese medicine is long, and the taste is poor. Patients cannot persist for a long time, resulting in treatment failure; and the existing western medicine still has side effects. The shortcoming of treating the symptoms but not the root cause and producing complications; the use of surgical treatment not only makes patients suffer from treatment risks and pains, but also the high cost of surgery increases people's economic pressure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A western medicine combination for the treatment of dry eye disease, which is composed of the following raw materials in parts by weight: 2 parts of rimexolone, 0.2 parts of vitamin A, 2 parts of sodium carboxymethyl cellulose, 5 parts of alpha modified starch, and cytarabine 1 part, abietic acid 0.5 part, 4-methoxybenzenesulfonyl hydrazide 0.1 part, furterine 1 part, ketoconazole 1 part, oleanolic acid 0.5 part, lansoprazole 1 part, 3-hydroxy-4 -0.2 parts of methoxybenzoic acid, 0.1 parts of β-sitosterol, 2 parts of taurine, and 45 parts of water.

[0022] A preparation method of a western medicine combination for the treatment of dry eye disease is characterized in that it comprises the following steps:

[0023] (1) In a sterile room, take rimexolone, abietic acid, 4-methoxybenzenesulfonyl hydrazide, furazolidin, ketoconazole, oleanolic acid, lansoprazole, vitamin A, carboxymethyl Sodium cellulose, 3-hydroxy-4-methoxybenzoic acid, cytarabine, β-sitosterol, and taurine are...

Embodiment 2

[0028] A combination of western medicine for the treatment of dry eye, which is composed of the following raw materials in parts by weight: 5 parts of rimexolone, 2 parts of vitamin A, 5 parts of sodium carboxymethyl cellulose, 10 parts of alpha modified starch, and 5 parts of cytarabine , 1 part of abietic acid, 1 part of 4-methoxybenzenesulfonyl hydrazide, 3 parts of furazolidone, 3 parts of ketoconazole, 1 part of oleanolic acid, 5 parts of lansoprazole, 3-hydroxy-4-methyl 1 part of oxybenzoic acid, 1 part of β-sitosterol, 5 parts of taurine, and 85 parts of water.

[0029] A method for preparing a combination of western medicines for the treatment of dry eye disease is characterized in that it comprises the following steps:

[0030] (1) In a sterile room, take rimexolone, abietic acid, 4-methoxybenzenesulfonyl hydrazide, furentine, ketoconazole, oleanolic acid, lansoprazole, vitamin A, carboxymethyl Sodium cellulose, 3-hydroxy-4-methoxybenzoic acid, cytarabine, β-sitosterol, a...

Embodiment 3

[0035] A combination of western medicine for the treatment of dry eye disease, consisting of the following parts by weight of raw materials: 3 parts of rimexolone, 0.8 parts of vitamin A, 3 parts of sodium carboxymethyl cellulose, 7 parts of alpha modified starch, and cytarabine 3 parts, abietic acid 0.7 parts, 4-methoxybenzenesulfonyl hydrazide 0.4 parts, furterine 2 parts, ketoconazole 2 parts, oleanolic acid 0.7 parts, lansoprazole 2 parts, 3-hydroxy-4 -0.5 parts of methoxybenzoic acid, 0.5 parts of β-sitosterol, 3 parts of taurine, and 50 parts of water.

[0036] A method for preparing a combination of western medicines for the treatment of dry eye disease is characterized in that it comprises the following steps:

[0037] (1) In a sterile room, take rimexolone, abietic acid, 4-methoxybenzenesulfonyl hydrazide, furazolidin, ketoconazole, oleanolic acid, lansoprazole, vitamin A, carboxymethyl Cellulose sodium, 3-hydroxy-4-methoxybenzoic acid, cytarabine, β-sitosterol, and tauri...

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PUM

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Abstract

The invention discloses a western medicine composition for treating xerophthalmia. The western medicine composition is prepared from the following raw materials in parts by weight: 2-5 parts of rimexolone, 0.2-2 parts of vitamin A, 2-5 parts of sodium carboxymethylcellulose, 5-10 parts of alpha modified starch, 1-5 parts of cytosine arabinoside, 0.5-1 part of abietic acid, 0.1-1 part of 4-methoxybenzenesulfonyl hydrazide, 1-3 parts of furazolidone, 1-3 parts of ketoconazole, 0.5-1 part of oleanolic acid, 1-5 parts of lansoprazole and 0.2-1 part of 3-hydroxyl-4-methoxybenzoic acid. The western medicine composition is excellent in curative effect on xerophthalmia, short in treatment cycle, good in taste, few in side effects, free of complications, simple in preparation method and low in production cost, and is capable of thoroughly curing xerophthalmia; the adherence to treatment of patients can be facilitated; the economic burden of people can be reduced.

Description

Technical field [0001] The invention relates to the technical field of western medicine preparation, in particular to a western medicine combination for treating dry eye disease. Background technique [0002] Dry eye syndrome refers to abnormal tear quality or quantity or abnormal dynamics caused by any reason, leading to a decrease in tear film stability, accompanied by ocular discomfort and (or) ocular surface tissue lesions. Also known as keratoconjunctival sicca. Common symptoms include dry eyes, easy tiredness, itchy eyes, foreign body sensation, burning sensation, sticky discharge, fear of wind, photophobia, and sensitivity to external stimuli; sometimes the eyes are too dry and there is not enough tears, but it stimulates reflex The secretion of tears results in frequent tears. In more severe cases, the eyes will be red, swollen, hyperemic, keratinized, and the corneal epithelium may be broken and filaments will adhere. This damage can cause corneal and conjunctival lesio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/718A61K9/20A61P27/02A61K31/07A61K31/18A61K31/185A61K31/19A61K31/192A61K31/422A61K31/4439A61K31/496A61K31/56A61K31/573A61K31/575A61K31/7068A61K31/717
CPCA61K31/573A61K9/2059A61K31/07A61K31/18A61K31/185A61K31/19A61K31/192A61K31/422A61K31/4439A61K31/496A61K31/56A61K31/575A61K31/7068A61K31/717A61K31/718A61K2300/00
Inventor 不公告发明人
Owner ZHENGZHOU ZHENGXIAN PHARMA CO LTD