Liquid increasing granule and preparation method thereof

A technology of granules and concentrates, applied in pharmaceutical formulations, granular material drying, lighting and heating equipment, etc., can solve the problems of many impurities, low content of active ingredients, affecting applications, etc., achieving simple and fast operation, simple equipment structure, and high efficiency. rate increase effect

Inactive Publication Date: 2017-02-22
滁州先奇工业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method in the prior art has rough and backward process, many impurities, and low active ingredient content, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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  • Liquid increasing granule and preparation method thereof
  • Liquid increasing granule and preparation method thereof
  • Liquid increasing granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 270g of Radix Scrophulariae, 216g of Rehmannia glutinosa, and 216g of Radix Ophiopogon japonicus, add 10 times the weight of medicinal materials in water, soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of medicinal materials in water, decoct for 1 hour, and filter the medicinal liquid The two decoction liquids were combined, concentrated under reduced pressure to a relative density of 1.05 at 60°C, added ethanol so that the volume percentage of the alcohol content reached 75%, stirred, left to stand, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65°C 1.25, and recover ethanol to obtain concentrated solution, use silica gel to refine, pre-load the selected silica gel into the resin column, and at the same time, after diluting the concentrated solution with purified water, pass it through a reversed-phase silica gel column to remove impurities in the liquid , collect all the effluent, continue to concentr...

Embodiment 2

[0024] Take 270g of Radix Scrophulariae, 216g of Rehmannia glutinosa, and 216g of Radix Ophiopogon japonicus, add 10 times the weight of medicinal materials in water, soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of medicinal materials in water, decoct for 1 hour, and filter the medicinal liquid The two decoction liquids were combined, concentrated under reduced pressure to a relative density of 1.05 at 60°C, added ethanol so that the volume percentage of the alcohol content reached 75%, stirred, left to stand, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65°C 1.25, and recover ethanol to obtain concentrated solution, use silica gel to refine, pre-load the selected silica gel into the resin column, and at the same time, after diluting the concentrated solution with purified water, pass it through a reversed-phase silica gel column to remove impurities in the liquid , collect all the effluent, continue to concentr...

Embodiment 3

[0029] Take 270g of Radix Scrophulariae, 216g of Rehmannia glutinosa, and 216g of Radix Ophiopogon japonicus, add 10 times the weight of medicinal materials in water, soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of medicinal materials in water, decoct for 1 hour, and filter the medicinal liquid The two decoction liquids were combined, concentrated under reduced pressure to a relative density of 1.05 at 60°C, added ethanol so that the volume percentage of the alcohol content reached 75%, stirred, left to stand, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65°C 1.25, and recover ethanol to obtain concentrated solution, use silica gel to refine, pre-load the selected silica gel into the resin column, and at the same time, after diluting the concentrated solution with purified water, pass it through a reversed-phase silica gel column to remove impurities in the liquid , collect all the effluent, continue to concentr...

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Abstract

The invention provides a liquid increasing granule and a preparation method thereof. The preparation method comprises the following steps: taking 270g of radix scrophulariae, 216g of radix rehmanniae recens and 216g of radix ophiopogonis, adding 10 times of water, soaking for 0.5h, decocting for 1 hour, filtering, adding 8 times of water into medicine residues, decocting for 1 hour, filtering out decoction and the like. By adopting special granule drying equipment, the content of harpagoside in the prepared liquid increasing granule is high, and the liquid increasing granule can be applied to preparation of drugs for inhibiting Chinese hamster ovary (CHO) cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extraction, in particular to a Zengye granule and a preparation method thereof. Background technique [0002] Zengye Granules nourish yin and promote body fluid, clear away heat and moisten dryness. It is used for yin deficiency and internal heat, dry mouth and throat, and dry stool caused by heat pathogens hurting yin and insufficient body fluid; it can also be used as an adjuvant drug for infectious diseases caused by high fever and depletion of body fluids. The preparation method in the prior art has a rough and backward process, many impurities, and low content of active ingredients, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. Contents of the invention [0003] Purpose of the invention: In order to solve the above problems, the purpose of the present invention is to provide a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/16A61P15/00F26B11/14F26B23/06
CPCA61K36/808A61K9/1605A61K36/804A61K36/8968A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55F26B11/14F26B23/06F26B2200/08A61K2300/00
Inventor 孙本如
Owner 滁州先奇工业科技有限公司
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