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Preparation method of functionally graded porous HA-Sr bone filled support with active interlayer

A functional gradient and interlayer technology, applied in medical science, prostheses, etc., can solve the problem that high porosity structure and high mechanical properties cannot coexist, and achieve the effect of promoting bone cell proliferation, maintaining mechanical stability, and convenient operation

Inactive Publication Date: 2017-02-22
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems existing in the current HA bone repair scaffold materials, the present invention provides a preparation method of a functionally gradient porous HA-Sr bone filling scaffold with an active interlayer; the purpose is to further improve the biological activity and osteogenic activity of the bone filling scaffold, and simultaneously Solve the problem that the high porosity structure and high mechanical properties of scaffold materials cannot coexist, and effectively improve the long-term stability of bone filling scaffolds implanted in bone defects

Method used

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  • Preparation method of functionally graded porous HA-Sr bone filled support with active interlayer
  • Preparation method of functionally graded porous HA-Sr bone filled support with active interlayer
  • Preparation method of functionally graded porous HA-Sr bone filled support with active interlayer

Examples

Experimental program
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Effect test

Embodiment 1

[0024] (1) According to the mass percentage of hydroxyapatite (HA) 97% and Sr 3%, respectively weigh 100 nm hydroxyapatite (HA) powder and Sr powder, put the powder into an agate ball mill jar for ball milling, After sealing with alcohol, evacuate to 20Pa, and then ball mill for 50 h, the resulting mixed HA-Sr powder is still placed in alcohol, and set aside;

[0025] (2) Mix the mixed HA-Sr powder obtained in step (1) with NH 4 HCO 3 The powder was mixed in the mixer for 120min to obtain mixed powder A; the mass percentage of HA-Sr powder in mixed powder A was 95%, NH 4 HCO 3 The mass percentage of the powder is 5%, and the average particle size of the sieve is 100 μm.

[0026] (3) According to Sr powder 95%, NH 4 HCO 3 5% mass percentage of powder, respectively weigh Sr powder and NH 4 HCO 3 The powders were mixed in a mixer for 30 minutes to obtain mixed powder B.

[0027] (4) Weigh 10 g of HA powder with a purity of more than 99.7% and a particle size of 100 nm, an...

Embodiment 2

[0032] (1) According to the mass percentage of 80% hydroxyapatite (HA) and 20% Sr, weigh 100 nm hydroxyapatite (HA) powder and Sr powder respectively, put the powder into an agate ball mill jar for ball milling, After sealing with alcohol, evacuate to 30Pa, and then ball mill for 100 h, the resulting mixed HA-Sr powder is still placed in alcohol, and set aside;

[0033] (2) Mix the mixed HA-Sr powder obtained in step (1) with NH 4 HCO 3 The powder was mixed in the mixer for 240min to obtain mixed powder A; the mass percentage of HA-Sr powder in mixed powder A was 75%, NH 4 HCO 3 The mass percentage of the powder is 25%, and the average particle size of the sieve is 700 μm.

[0034] (3) According to powder Sr 90%, NH 4 HCO 3 10% by mass of powder, weigh Sr powder and NH respectively 4 HCO 3 The powders were mixed in a mixer for 60 minutes to obtain mixed powder B.

[0035] (4) Weigh 20g of HA powder with a purity of more than 99.7% and a particle size of 100nm, record i...

Embodiment 3

[0040] (1) According to the mass percentage of hydroxyapatite (HA) 85% and Sr 15%, respectively weigh 100 nm hydroxyapatite (HA) powder and Sr powder, put the powder into an agate ball mill jar for ball milling, After sealing with alcohol, evacuate to 25Pa, and then ball mill for 80 h, the resulting mixed HA-Sr powder is still placed in alcohol, and set aside;

[0041] (2) Mix the mixed HA-Sr powder obtained in step (1) with NH 4 HCO 3 The powder was mixed in the mixer for 200min to obtain mixed powder A; the mass percentage of HA-Sr powder in mixed powder A was 80%, NH 4 HCO 3 The mass percentage of the powder is 20%, and the average particle size of the sieve is 500 μm.

[0042] (3) According to Sr powder 90%, NH 4 HCO 3 10% by mass of powder, weigh Sr powder and NH respectively 4 HCO 3 The powders were mixed in a mixer for 55 minutes to obtain mixed powder B.

[0043] (4) Weigh 15g of HA powder with a purity of more than 99.7% and a particle size of 100nm, record it...

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Abstract

The invention discloses a functionally graded porous HA-Sr bone filling support with an active interlayer, belonging to the technical field of biomedical material preparation. The functionally graded porous HA-Sr bone filling support material with the active interlayer can be obtained by weighing HA and Sr powder according to the component ratio and then ball-milling the HA and Sr powder; weighing the mixed powder and an ammonium bicarbonate pore former according to the porosity ratio and mixing the mixed powder with the ammonium bicarbonate pore former; carrying out graded laying on the three kinds of powder after the three kinds of powder is prepared, mechanically pressing the powder into a blocky pressing blank, then putting the blocky pressing blank in a spark plasma sintering furnace, carrying out sintering after the system is vacuumized till 2-6 Pa, carrying out insulation at 800-1000 DEG C for 5-10 minutes and carrying out furnace cooling till the room temperature, wherein the heating rate is 50-100min / DEG C. The material can actively induce osteocyte to adhere to and proliferate on the surface of the material, has good osteogenic activity, has high porosity, also has high mechanical stability and can serve as a good artificial bone filling material.

Description

technical field [0001] The invention relates to a preparation method of a functionally gradient porous HA-Sr bone filling scaffold with an active interlayer, and belongs to the technical field of preparation of biomedical materials. Background technique [0002] Hydroxyapatite (HA) is considered to be the preferred scaffold or filling material in the field of bone repair because of its chemical structure similar to human bone and excellent biological activity. Strontium (Sr) can effectively promote bone healing and new bone growth due to its unique therapeutic effect in osteoporosis, increase bone formation and reduce bone resorption. Cell experiments have proved that the fusion of Sr can effectively promote the proliferation and differentiation of osteoblasts. In addition, pre-clinical experiments have also confirmed that the release of Sr ions can enhance the bone density of different parts, including the lumbar spine, femoral neck and hip joints, and can effectively prev...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/04A61L27/56A61L27/50A61L27/54B22F7/02B22F3/105
CPCA61L27/047A61L27/12A61L27/50A61L27/54A61L27/56A61L2300/102A61L2300/412B22F3/105B22F7/02B22F2003/1051B22F2998/10B22F2999/00B22F1/0003B22F3/02B22F2207/01
Inventor 潘学坤谢辉陆玉姬
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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