A kind of preparation method of anticoagulant hemodialysis membrane
A technology of hemodialysis and anticoagulation, which is applied in the field of preparation of anticoagulant hemodialysis membranes, can solve the problems of loss and loss of anticoagulation performance of hemodialysis membranes, and achieve the solution of coagulation problems, easy industrial production, and low cost Effect
Active Publication Date: 2019-04-16
江苏朗生生命科技有限公司
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Problems solved by technology
However, as a water-soluble polymer, polyvinylpyrrolidone (PVP) will dissolve in water and be lost during the preparation and use of the dialysis membrane, resulting in the loss of the anticoagulant performance of the hemodialysis membrane.
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[0019] The preparation method of an anticoagulant hemodialysis membrane of the present invention is carried out in the following steps:
[0020] (1) Hydrolysis treatment of polyvinylpyrrolidone.
[0021] In the present invention, polyvinylpyrrolidone and deionized water are added into a reaction kettle at a mass ratio of 0.01-0.2:1, and then an acidic hydrolysis catalyst or an alkaline hydrolysis catalyst is added to make the polyvinylpyrrolidone aqueous solution undergo hydrolysis reaction at a temperature of 55-95°C , The reflux time is controlled at 1.5~2h to obtain modified polyvinylpyrrolidone with carboxyl and amine active groups. The original chemically stable polyvinylpyrrolidone is hydrolyzed, and part of the amide bond is hydrolyzed to form reactive amines. Group and carboxyl group to obtain reactive functional groups in the structure of polyvinylpyrrolidone. Heat and evaporate the remaining deionized water to obtain modified polyvinylpyrrolidone, which is dried in vacuu...
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The invention relates to a preparation method of an anticoagulation hemodialysis membrane. The preparation method comprises the following steps: adding polyvinylpyrrolidone and deionized water into a reaction vessel according to mass ratio of 0.01-0.2:1, adding a hydrolysis catalyst and carrying out reflux at the temperature of 55-95 DEG C for 1.5-2 h so as to obtain modified polyvinylpyrrolidone with carboxyl and amino active groups; soaking a cleaned hemodialysis membrane in the modified polyvinylpyrrolidone aqueous solution and controlling soaking time within 0.5-50 h, taking the hemodialysis membrane out and standing, and air-drying; carrying out a cross-linking reaction by soaking the hemodialysis membrane in a cross-linking agent solution, and obtaining a functional layer containing modified polyvinylpyrrolidone group on the surface of the hemodialysis membrane and inside membrane holes; and cleaning the modified hemodialysis membrane with n-hexane, cleaning the modified hemodialysis membrane with ethanol, cleaning the modified hemodialysis membrane with deionized water, and removing residual reactant and solvent. As the stable anticoagulation functional layer is formed on the surface of the hemodialysis membrane and inside the membrane holes, performance of the hemodialysis membrane can be improved.
Description
Technical field [0001] The invention relates to a method for preparing an anticoagulant hemodialysis membrane, belonging to the technical field of hollow fiber hemodialysis membranes. Background technique [0002] Hemodialysis is the main method for the treatment of patients with acute and chronic renal failure. Hemodialysis membranes are very important in hemodialysis products. In the dialysis process, when the poorly biocompatible hemodialysis membrane comes into contact with blood, it may destroy red blood cells, activate and aggregate platelets, and then form thrombus, causing blood clotting, blocking membrane fiber ducts, affecting the progress of dialysis and reducing dialysis The effect of treatment. [0003] At present, in clinical aspects, there is no artificial medical biomaterial that can be perfectly applied in the human body. Blood compatibility is the most important performance index of biomaterials, and the anticoagulant performance is the decisive factor that dete...
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IPC IPC(8): B01D71/82B01D69/08B01D69/02B01D67/00A61M1/18
Inventor 戈旭亚于海军
Owner 江苏朗生生命科技有限公司