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A method for improving blood compatibility of medical titanium alloy

A blood compatibility, titanium alloy technology, applied in metal material coating process, electrolytic coating, surface reaction electrolytic coating, etc. The effect of low production cost and easy product quality

Inactive Publication Date: 2016-11-16
NANCHANG HANGKONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these research works have made progress, the blood coagulation problem of titanium alloys has not been completely solved in clinical applications.

Method used

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  • A method for improving blood compatibility of medical titanium alloy
  • A method for improving blood compatibility of medical titanium alloy

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Ti-6Al-4V alloy surface pretreatment, degreasing, SiC sandpaper grinding and mechanical polishing;

[0018] (2) Put the pretreated Ti-6Al-4V alloy into 10g / L trisodium phosphate aqueous solution to carry out micro-arc oxidation treatment, the treatment voltage is 400V, and the treatment time is 10min;

[0019] (3) Soak the sample in anhydrous ethanol solution of perfluorozinc-based trichlorosilane for 12 hours;

[0020] (4) Rinse and dry at 50°C to obtain a super-hydrophobic coating on the surface of the Ti-6Al-4V alloy to improve the blood compatibility of the Ti-6Al-4V alloy.

[0021] The invention can form a superhydrophobic titanium dioxide coating on the surface of the biomedical Ti-6Al-4V alloy, the surface micropore diameter is 200~1000nm, the contact angle can reach 153˚, the hemolysis rate is 0.4%, and the sample in the platelet adhesion test There is almost no platelet adhesion on the surface.

Embodiment 2

[0023] (1) NiTi alloy surface pretreatment, degreasing, SiC sandpaper grinding and mechanical polishing;

[0024] (2) Put the pretreated NiTi alloy into 12g / L sodium aluminate + 1g / L sodium hypophosphite aqueous solution for micro-arc oxidation treatment, the treatment voltage is 400V, and the treatment time is 10min;

[0025] (3) Soak the sample in anhydrous ethanol solution of perfluorozinc-based trichlorosilane for 18 hours;

[0026] (4) Rinse and dry at 60°C to obtain a super-hydrophobic coating on the surface of NiTi to improve the blood compatibility of the NiTi alloy.

[0027] The invention can form a super-hydrophobic alumina coating on the surface of biomedical NiTi, the diameter of micropores on the surface is 500-1500nm, the contact angle can reach 157°, the hemolysis rate is 0.3%, and there is almost no coating on the surface of the sample in the platelet adhesion test. Platelet adhesion.

Embodiment 3

[0029] (1) Ti-6Al-7Nb alloy surface pretreatment, degreasing, SiC sandpaper grinding and mechanical polishing;

[0030] (2) Put the pretreated NiTi alloy into 30mL / L phosphoric acid aqueous solution for micro-arc oxidation treatment, the treatment voltage is 400V, and the treatment time is 10min;

[0031] (3) Soak the sample in anhydrous ethanol solution of perfluorozinc-based trichlorosilane for 6 hours;

[0032] (4) Rinse and dry at 70°C to obtain a superhydrophobic coating on the surface of the Ti-6Al-7Nb alloy and improve the blood compatibility of the Ti-6Al-7Nb alloy.

[0033] The invention can form a superhydrophobic titanium dioxide coating on the surface of biomedical Ti-6Al-7Nb alloy, the surface micropore diameter is 100-1000nm, the contact angle can reach 155°, the hemolysis rate is 0.5%, and the sample in the platelet adhesion test There is almost no platelet adhesion on the surface.

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Abstract

A method for improving blood compatibility of medical titanium alloy, the method steps are: (1) titanium alloy surface pretreatment, degreasing, SiC sandpaper grinding and mechanical polishing; (2) performing micro-arc oxidation on the pretreated titanium alloy (3) Soak the titanium alloy after micro-arc oxidation treatment in perfluorozinc-based trichlorosilane solution for 6~24h to modify the surface; (4) Rinse, 50~ Dry at 70°C to obtain a super-hydrophobic film on the surface of the titanium alloy and improve the blood compatibility of the titanium alloy. The preparation method of the invention is simple, the production cost is low, the product quality is easy to control, the environment is not polluted, and the blood compatibility of the titanium alloy can be greatly improved.

Description

technical field [0001] The invention relates to the preparation of a superhydrophobic film on the surface of a medical titanium alloy, in particular to a method for improving the blood compatibility of the medical titanium alloy. Background technique [0002] Titanium and titanium alloys have the advantages of small specific gravity, good mechanical properties, strong corrosion resistance, easy processing and excellent biocompatibility, making them one of the most important biomedical materials. In recent years, titanium alloy materials have been increasingly used in the research and development of medical materials that are in direct contact with human blood, such as: hemodialysis systems, extracorporeal circulation systems, vascular stents, heart valves, ventricular assist devices and catheters, etc. . When the material is in direct contact with blood, a series of biological reactions will occur between the blood and the material. Plasma proteins are adsorbed on the surf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23F17/00C25D11/26C23C22/02
Inventor 徐吉林姜久仰罗军明梅丁丁
Owner NANCHANG HANGKONG UNIVERSITY