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Novel formula and preparation method of diclazuril solution

A diclazuril and prescription technology, which is applied in the direction of medical preparations, pharmaceutical formulas, drug combinations, etc. of non-active ingredients, can solve the problem of diclazuril solution color deepening, etc., to increase solubility and stability, Avoid heating steps, reduce degradation effects

Active Publication Date: 2017-03-08
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to address the above problems, to propose a new diclazuril solution prescription, under the condition of ensuring the good water solubility of the solution, to solve the problem that the diclazuril solution is degraded during storage and transportation and causes the color to deepen The problem

Method used

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  • Novel formula and preparation method of diclazuril solution
  • Novel formula and preparation method of diclazuril solution
  • Novel formula and preparation method of diclazuril solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Each 500ml diclazuril solution consists of the following raw materials:

[0024]

[0025] Weigh 0.2g of citric acid and dissolve in 50ml of distilled water; weigh 0.8g of propyl gallate and dissolve in 250ml of N,N-dimethylacetamide and 100ml of ethyl lactate mixed solvent; mix the above two solutions evenly, add 2.5 g diclazuril, after stirring and dissolving, add 5.0 g co-solvent polyoxyl 40 stearate in the stirring state, after completely dissolving, finally dilute to 500 ml with absolute ethanol. Filter, fill, seal and store away from light.

Embodiment 2

[0027] Each 500ml diclazuril solution consists of the following raw materials:

[0028]

[0029] Weigh 1.0g of L-ascorbic acid and dissolve it in 50ml of distilled water; weigh 5.0g of tert-butyl hydroquinone and dissolve it in 100ml of N-methylpyrrolidone; mix the above two solutions evenly, and add 2.5g of diclazuril raw material. Add 7.0 g castor oil polyoxyl 35 ester and 3.0 g co-solvent poloxamer 188 under stirring state, and dilute to 500 ml with absolute ethanol after completely dissolving. Filter, fill, seal and store away from light.

Embodiment 3

[0031] Each 500ml diclazuril solution consists of the following raw materials:

[0032]

[0033] Weigh 5.0g D-sodium ascorbate and dissolve it in 50ml distilled water; weigh 5.0g propyl gallate and dissolve it in 200ml N,N-dimethylformamide, mix the above two solutions evenly, add 5.0g diclazuril raw material. Add 5.0 g of co-solvent poloxamer 124 and 10.0 g of povidone K30 under stirring state, after completely dissolving, add 100 ml of propylene glycol, and then dilute to 500 ml with absolute ethanol. Check the appearance and properties, and store in a sealed and dark place.

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Abstract

The invention discloses a novel formula of a preparation method of a diclazuril solution. The diclazuril solution is composed of 0.5 to 5% of diclazuril, 0.02 to 10% of antioxidant, 1 to 10% of cosolvent, and mixed solvent being added to 100%. The provided diclazuril solution can be well dissolved in water; no precipitate is generated during the dilution process, moreover, the diclazuril solution is evenly dispersed; and the quantitative dosing for poultry becomes convenient therefore. The coccidial infection of poultry can be effectively treated in time. The bioavailability is high, the drug waste is avoided, and the blocking of drinking equipment is avoided. Furthermore, the stability of the diclazuril solution is good; after high temperature acceleration and long term storage at a room temperature, the indexes of the diclazuril solution such as properties, clarity, content, related substances, and the like barely change; and the diclazuril content is still more than 95% of the labeled content.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a new prescription of poultry anticoccidial drug diclazuril solution and a preparation method thereof. Background technique [0002] Poultry coccidiosis is a parasitic disease that is extremely harmful to the aquaculture industry. Coccidiosis often causes 15-50-day-old chicks to become ill, and the mortality rate is as high as 80%. The recovered chicks have severely retarded growth, reduced resistance, and are prone to other diseases. It is reported in the literature that the annual loss of poultry coccidiosis in the world reaches more than 1 billion US dollars, and the annual consumption of anticoccidial drugs reaches 320 million US dollars. [0003] Diclazuril belongs to the triazine phenacetin compound, which has high-efficiency, low-toxicity and broad-spectrum anticoccidial efficacy. Its effect on coccidia is mainly at the peak of coccidia reproduct...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/14A61K47/10A61K47/12A61K47/04A61K31/53A61P33/14
Inventor 魏微李旭东刘爱玲井丁丁聂丽娜付春香
Owner RINGPU TIANJIN BIOLOGICAL PHARMA