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Composition for treating gynecological disease, agent containing composition and preparation method of composition

A technology for gynecological diseases and compositions, applied in the field of medicine, can solve problems such as incompleteness and slow absorption of drugs, and achieve the effects of fast absorption, small dosage, and convenient carrying and taking.

Inactive Publication Date: 2017-03-22
YANGLING CHARISMA BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral liquid is in a sugar-free dosage form, which can effectively overcome the disadvantages of Penyanjing common solid oral preparations, which have strong hygroscopicity and slow disintegration due to the fact that it contains more traditional Chinese medicine extracts, resulting in slow and incomplete drug absorption. In addition to the advantages of small dose, fast absorption, stable quality, convenient carrying and taking, more importantly, the stability is better than the original sugar dosage form, and at the same time, the scope of patients is expanded, including gynecological patients with abnormal blood sugar.

Method used

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  • Composition for treating gynecological disease, agent containing composition and preparation method of composition
  • Composition for treating gynecological disease, agent containing composition and preparation method of composition
  • Composition for treating gynecological disease, agent containing composition and preparation method of composition

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preparation example Construction

[0021] Specifically, a sugar-free preparation of Penyanjing oral liquid, the preparation process see figure 1 . It is characterized in that the weight ratio of the preparation is:

[0022]

[0023] And, the preparation of a kind of sugar-free type Penyanjing oral liquid is characterized in that, its preparation steps are:

[0024] (1) Penyanjing extract: take 500 parts of Lonicerae vine, 500 parts of Dandelion, 500 parts of Miltonia Spatholobus, 200 parts of Motherwort, 200 parts of Dog Ridge, 200 parts of Plantain, 120 parts of Radix Paeoniae Rubra, 120 parts of Chuanxiong Bawei Mix the medicinal materials, add 8 times the amount of water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25 (90°C), add ethanol to make the alcohol content 65%, stir well , stand still for 12 hours, filter the supernatant, recycle ethanol to a relative density of 1.30 (60-65°C) clear paste.

[0025] (2) Preparatio...

Embodiment 1

[0036] Embodiment 1 Prescription process optimization

[0037] The present invention has carried out following prescription and technology preferably:

[0038](1) Preparation of extraction extract: Take 1500g of honeysuckle, 1500g of dandelion, 1500g of Caulis Spatholobus, 600g of motherwort, 600g of dog ridge, 600g of plantain, 360g of red peony root, 360g of Chuanxiong and more than eight herbs into the extraction tank (500L) medium, mix well, add 94L of water and decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25 (90°C) to obtain 4.1kg of water extract, add 11L of ethanol to reduce the alcohol content 65%, stir well, let stand for 12 hours, filter the supernatant, recover ethanol until the relative density is 1.30 (60-65°C) to obtain 2.11kg of extract.

[0039] (2) Preliminary screening of prescriptions: 300mL (corresponding to the weight of the extract 211g) of the preparation obtained in the prev...

Embodiment 2

[0046] Example 2 Preparation of Sugar-free Penyanjing Oral Liquid Preparation

[0047]

[0048] Take 500 parts of Lonicerae vine, 500 parts of Dandelion, 500 parts of Miltonia Spatholobus, 200 parts of Motherwort, 200 parts of Dog Ridge, 200 parts of Plantain, 120 parts of Radix Paeoniae Rubra, 120 parts of Chuanxiong Rhizoma Rhizoma Chuanxiong, add 8 times the amount of water Decoct twice, each time for 2 hours, combine the decoction, filter, concentrate the filtrate to a relative density of 1.25 (90°C), add ethanol to make the alcohol content 65%, stir well, let stand for 12 hours, filter and collect Clear liquid, recover ethanol to a relative density of 1.30 (60-65°C) clear paste. Separately take sucralose, sodium benzoate, add appropriate amount of water, dissolve, filter, mix with the above concentrated solution, add appropriate amount of purified water to make 1000ml, stir well, potting, and sterilize to obtain.

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Abstract

The invention relates to the technical field of medicine, in particular to a composition for treating the gynecological disease, an agent containing the composition and a preparation method of the composition. The preparation method of the composition comprises the steps that 50 parts of honeysuckle stems, 500 parts of dandelions, 500 parts of suberect spatholobus stems, 200 parts of herba leonuri, 200 parts of rhizoma cibotii, 200 parts of plantain herb, 120 parts of the root of common peony and 120 parts of the rhizome of chuanxiong are taken to be mixed to be uniform, eight-time water is added for decoction twice, each time of decoction lasts for 2 h, decoction liquid is mixed, stirring to be uniform is carried out, and still standing is carried out for 12 h; and supernate is taken in a filtering manner, and ethyl alcohol is recycled till clear paste with the relative density of 1.25-1.30 (60 DEG C to 65 DEG C) is obtained. Saccharose, glucose and nutritional sugar influencing blood glucose are not adopted, and a sweetening agent which has no influence on the blood glucose after being taken is adopted. The quality stability of the sugar-free pelvic inflammation eliminating oral liquid prepared through the method is better than that of sugar containing oral liquid, the preparation is good in taste, the range of taking patients is widened, and people suffering from pathoglycemia are included.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition for treating gynecological diseases, a medicament containing the composition and a preparation method thereof. Background technique [0002] Chronic pelvic inflammatory disease is one of the top ten refractory diseases, and it is a common and frequently-occurring disease in gynecology. Penyanjing Oral Liquid has been proven to be an effective medicine for clearing away heat (detoxification) and promoting dampness, and mainly treating damp-heat (heat-toxin) accumulation type of pelvic inflammatory disease. The prescription is composed of eight medicinal materials such as "Honeysuckle Vine, Dandelion, Millet Spatholobus, Motherwort, Dog Rib, Plantain, Radix Paeoniae Rubra, Chuanxiong". It is widely used in various gynecological inflammations in Yunnan, Hunan and Yunnan, and it is still used today. After decades of continuous improvement, the clinical efficacy is mo...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/68A61K9/08A61K47/26A61P15/00
CPCA61K36/355A61K9/0053A61K9/08A61K36/11A61K36/236A61K36/288A61K36/486A61K36/533A61K36/65A61K36/68A61K36/71A61K47/26A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 郁慧姚奔高建昌杨朝福
Owner YANGLING CHARISMA BIO PHARMA CO LTD
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