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Preparation method of compound male silkworm moth oral liquid capable of nourishing sperm

A technology of compound male moth and oral liquid, which is applied in the field of medicine, can solve the problems of insufficient extraction of active ingredients of medicinal materials, long production cycle, and high production cost, and achieve the effects of good product properties, short production cycle, and low equipment investment cost

Inactive Publication Date: 2017-03-22
HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitation of the production process in the early years, the extraction of the active ingredients of the medicinal materials was insufficient, the production cycle was too long, and the production cost was too high

Method used

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  • Preparation method of compound male silkworm moth oral liquid capable of nourishing sperm
  • Preparation method of compound male silkworm moth oral liquid capable of nourishing sperm
  • Preparation method of compound male silkworm moth oral liquid capable of nourishing sperm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Formula

[0019]

[0020] (2) Preparation process

[0021] Take the male silkworm moths that have been washed, drained, and dried to remove the legs and wings, crush and sieve, then soak twice with 50% (by volume) ethanol, each time for 7 days, stir twice a day, and filter the soaking solution , the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.00 (80°C), and made a fluid extract for subsequent use;

[0022] Acanthopanax senticosus medicinal materials were prepared according to the preparation method of Chinese Pharmacopoeia to make acanthopanax alcoholic extract, and set aside. Take Acanthopanax extractum and add a small amount of water to dissolve it, add ethanol to make the alcohol content reach 75%, let it stand for 12 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 5 times the amount of water, and refrigerate (4-6 °C) for 48 hours, filtered, and the filtrate was concentrated...

Embodiment 2

[0026] (1) Formula

[0027]

[0028] (2) Preparation process

[0029] Get the male silkworm moths that have been cleaned, drained, and dried to remove the legs and wings, then pulverize and sieve, then soak twice with 45% (by volume) ethanol, each time for 7 days, stir twice a day, and filter the immersion solution. Ethanol was recovered from the filtrate under reduced pressure and concentrated to a relative density of 1.05 (70°C) to make a liquid extract for later use;

[0030] Acanthopanax senticosus medicinal materials were prepared according to the preparation method of Chinese Pharmacopoeia to make acanthopanax alcoholic extract, and set aside. Take Acanthopanax extractum and add a small amount of water to dissolve it, add ethanol to make the alcohol content reach 70%, let it stand for 12 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 6 times the amount of water, and refrigerate (4-6 °C) for 48 hours, filtered, and the filtrat...

Embodiment 3

[0034] (1) Formula

[0035]

[0036] (2) Preparation process

[0037] Get the male silkworm moths that have been cleaned, drained, and dried to remove the legs and wings, then pulverize and sieve, then soak twice with 45% (by volume) ethanol, each time for 7 days, stir twice a day, and filter the immersion solution. Ethanol was recovered from the filtrate under reduced pressure and concentrated to a relative density of 1.00 (80°C) to make a liquid extract for later use;

[0038] Acanthopanax senticosus medicinal materials were prepared according to the preparation method of Chinese Pharmacopoeia to make acanthopanax alcoholic extract, and set aside. Take Acanthopanax extractum and add a small amount of water to dissolve it, add ethanol to make the alcohol content reach 80%, let it stand for 12 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 4 times the amount of water, refrigerate (4-6 °C) for 48 hours, filtered, and the filtrate wa...

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Abstract

The invention provides a preparation method of a compound male silkworm moth oral liquid capable of nourishing sperm. Each 1000ml of the compound male silkworm moth oral liquid is composed of 110 to 140 male silkworm moths, 40 to 55g of herba epimedii, 10 to 25g of fructus psoraleae, 15 to 25g of radix rehmanniae praeparata, 30 to 40g of radix acanthopanacis semticosi, 30 to 40g of semen cuscutae, 7 to 9g of radix polygonum multiflorum preparata, and 200g of sucrose. The preparation method comprises following steps: the male silkworm moths are extracted via cold leaching; alcohol heating reflux is adopted to extract herba epimedii, fructus psoraleae, radix rehmanniae praeparata, semen cuscutae, and radix polygonum multiflorum preparata; a radix acanthopanacis semticosi extract obtained via treatment, and an obtained male silkworm moth extract are weighed at a certain ratio, water is added, wherein the adding amount of water accounts for 7 to 9 times of the total amount of the radix acanthopanacis semticosi extract and the male silkworm moth extract; an obtained mixture is stirred to be uniform, is stored at 4 to 6 DEG C for 48h, and is filtered; an obtained filtrate is concentrated until relative density ranges from 1.05 to 1.10 (60 DEG C); 200g of sucrose is added, stirring is carried out for dissolving, heating sterilization is carried out, an appropriate amount of ethanol is added so as to obtain a mixed material with an ethanol content ranging from 5 to 8%; water is added until the total volume of an obtained product reaches 1000ml; and uniform stirring, filtering, filling, sterilizing, and packaging are carried out so as to obtain a finished product. According to the preparation method, the extraction ratio of each medical material is increased to certain degrees by novel technology, the content of each index component is increased obviously, and especially, the yield of male silkworm moth nutritional active ingredients is increased obviously; and in addition, the preparation method possesses advantages such as excellent product character, high stability, short production period, and relatively low equipment investment cost, so that the preparation method is more suitable to be applied in large-scale production and applications.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method for producing compound male moth Yijing oral liquid. Background technique [0002] Compound Male Moth Yijing Oral Liquid is prepared from raw materials such as male silkworm moth, epimedium and psoralen through a series of strict production processes. This product is used for warming kidney and benefiting essence. It is suitable for fatigue, weak waist and knees, forgetful tinnitus, night sleep and dreaminess, chills and frequent urination due to deficiency of kidney yang. Silkworm moths take males and use them as medicine. "Compendium of Materia Medica" once said that it "can strengthen yang and stop diarrhea", so it is used as a monarch drug. Recent studies have shown that male silkworm moths are rich in amino acids, proteins, brain hormones, and male hormones. Active substances such as hormones can promote protein synthesis in the human body, improve ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/08A61P15/10A61P1/14A61K35/64
CPCA61K47/26A61K9/0053A61K9/08A61K35/63A61K36/254A61K36/296A61K36/39A61K36/43A61K36/487A61K36/704A61K36/804A61K2236/333A61K2236/39A61K2300/00
Inventor 芦传有赵冬艳范宁商萍孟凤梅王新国
Owner HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD