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Medicine for treating colitis and application of compound to preparation of medicine for treating colitis

A colitis and drug technology, applied in the field of medicine, can solve the problem of low effective rate, achieve the effects of reducing release, improving tissue pathological conditions, and reducing MPO activity

Inactive Publication Date: 2017-03-29
云天下(广州)企业管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment strategy focuses on controlling inflammation and regulating immunity, mainly using anti-inflammatory drugs and immunosuppressive drugs, but the current situation of low effective rate has not been overcome

Method used

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  • Medicine for treating colitis and application of compound to preparation of medicine for treating colitis
  • Medicine for treating colitis and application of compound to preparation of medicine for treating colitis
  • Medicine for treating colitis and application of compound to preparation of medicine for treating colitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0034] Experimental example Therapeutic effect of the medicine of the present invention on colitis

[0035] Medicine of the present invention:

[0036] Take 30 SD rats, female, with a body weight of 220-240 g, and randomly divide them into 3 groups, which are the normal control group (modeling with 0.9% sodium chloride aqueous solution + intraperitoneal injection of an equal volume of 0.9% sodium chloride aqueous solution), and the model control group. (TNBS modeling+peritoneal injection equal volume of 0.9% sodium chloride aqueous solution) and the drug group of the present invention (TNBS modeling+peritoneal injection of medicine 2.1mg kg of the present invention) -1), 10 in each group. Rats were fasted for 24 h before modeling and had free access to water. Reference "Zhou Yanhong, He Xiaofei, Bai Yuting, et al. Effect of Ginkgo biloba extract on the expression of tumor necrosis factor-α in rats with experimental colitis [J]. Chinese Pharmacology Bulletin, 2007,23(12):16...

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Abstract

The invention relates to a medicine for treating colitis. The medicine comprises a compound shown in the following formula, and the medicine can be a stereoisomer of the compound, or a geometrical isomer of the compound, or a tautomer of the compound, or pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable carrier, or a pharmaceutically acceptable excipient, or a pharmaceutically acceptable diluent, or a pharmaceutically acceptable adjuvant, or a pharmaceutically acceptable medium or pharmaceutically acceptable combinations of the carrier, the excipient, the diluent, the adjuvant and the medium. Please see the specifications for the formula, R1 is F, or Cl, or Br or I, and R2 is F, or Cl, or Br or I. The medicine can relieve the tissue pathological change states, remarkably lower MPO activity and the content of TNF-alpha and IL-beta, and reduce releasing of inflammatory factors, and the medicine can be hopefully developed into a novel medicine for clinic use.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a medicine for treating colitis and its application in preparing medicine for treating colitis. Background technique [0002] Colitis is the term used to describe inflammation of the colon. There are several causes of colitis, including infection, poor blood supply, and autoimmune reactions. The colon wall has many layers. There is a layer of smooth muscle that wraps around the exterior and is responsible for compressing undigested food longitudinally along the colon. The inner layer, or mucous membrane, is in contact with the fluid and allows water and electrolytes to be absorbed to help solidify the stool. The mucosal layer is where inflammation of the colon occurs and bears the symptoms of colitis. [0003] Colitis is a chronic intestinal non-specific inflammatory disease with uncertain etiology and pathogenesis. It is currently believed that intestinal mucos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/513A61P29/00A61P1/00
CPCA61K31/513
Inventor 田凤香
Owner 云天下(广州)企业管理有限公司
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