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Implanted device and preparation method thereof

An implantable, device technology, applied in instruments, optical components, pressure sensors, etc., can solve problems such as being in the research and development stage, patient pain, poor air tightness, etc.

Inactive Publication Date: 2017-04-26
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The recently reported use of implantable intraocular lenses to monitor intraocular pressure in real time is sensitive, but its design is complex and its airtightness is poor. It is very inconvenient to collect results by observing the position of the air column in the microchannel (Nature Medicine, 2014.20, 1074-1078)
Taking blood glucose detectors as an example, invasive or minimally invasive methods are commonly used for blood glucose detection, which not only brings great pain to patients, but also cannot monitor effectively for a long time in real time
Recently, Google is developing a glucose monitor based on contact lenses, which is based on electrochemical detection, but it is still in the research and development stage

Method used

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  • Implanted device and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] An embodiment of the color-changing implantable device of the present invention, the implantable device is an intraocular lens, and the preparation method of the color-changing intraocular lens includes the following steps:

[0073] (1) Get a polypropylene intraocular lens mold, which includes a separable upper mold and a lower mold, wherein the upper mold has a convex spherical surface, and the lower mold has a concave spherical surface, and the femtosecond pulse two-photon polymerization method is used to form a mold on the lower mold. A photonic crystal structure layer is prepared on the concave spherical surface of the photonic crystal structure, and a mold with a photonic crystal structure is obtained. The photonic crystal structure is periodically arranged micro-nano spherical pits, and the size of the spherical pits is 200nm;

[0074] (2) After mixing the silica gel and its curing agent according to the mass ratio of 1:1, take 50 microliters of the precursor solut...

Embodiment 2

[0077] An embodiment of the color-changing implantable device of the present invention, the implantable device is an intraocular lens, and the preparation method of the color-changing intraocular lens includes the following steps:

[0078] 1. Preparation of colloidal photonic crystal particles:

[0079] 5 mL of monodisperse polystyrene microspheres with a diameter of 400 nm were configured into an emulsion with a mass concentration of 5.0 wt%, and then dispersed into 80 mL of n-hexadecane containing surfactant Hypermer 2296 (1.0 wt%) , self-assembled in an oven at 50°C for 72 hours to obtain colloidal photonic crystal particles. Then, the colloidal photonic crystal particles are fully washed with n-hexane to remove the n-hexadecane, and then dried to obtain the colloidal photonic crystal particles. The colloidal photonic crystal particles are dispersed into the mixed solution of hydroxyethyl methacrylate and methylene bisacrylamide (the molar ratio of hydroxyethyl methacrylat...

Embodiment 3

[0083] An embodiment of the color-changing implantable device of the present invention, the implantable device is an intraocular lens, and the preparation method of the color-changing intraocular lens includes the following steps:

[0084] 1. Preparation of colloidal photonic crystals:

[0085] Take 20 microliters of monodisperse silicon dioxide photonic crystal microspheres with a diameter of 1 micron to form a dispersion with a mass concentration of 2.0 wt%, and then drop them into the lower mold of the intraocular lens, and self-assemble in an oven at 90°C for 15 minutes, The colloidal photonic crystal particle film can be obtained.

[0086] 2. Precursor solution solidification

[0087] Then add 50 microliters of the mixed solution of methyl methacrylate and ethylene glycol dimethacrylate to the lower mold assembled with photonic crystal film (the moles of methyl methacrylate and ethylene glycol dimethacrylate ratio of 25:1), using dialkoxyacetophenone (mass volume ratio:...

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Abstract

The invention provides an implanted device. The implanted device comprises an optical crystal; the optical crystal is acted as a color element and distributed in an artificial crystal body and forms a structural color pattern. The implanted device can be popularized to the implanted vision adjusting material, eye pressure monitoring, and cataract crystal body design; more importantly, the color variable implanted device can be used for accurately monitoring intraocular tension in real time, the real-time monitoring or physical sign monitoring of the intraocular tension can be realized only through the color change, and the major difficulties that the existed intraocular tension and glucose monitoring are not in real time and inaccurate, and data reading is difficult can be solved. The mould method can realize the high-efficiency and high-quality preparation on a large batch of the implanted device.

Description

technical field [0001] The invention relates to an implanted device, in particular to a color-changing implanted device and a preparation method thereof. Background technique [0002] In recent years, with the serious aging phenomenon, various chronic diseases have increased rapidly, and glaucoma and diabetes, as diseases that cannot be completely cured, have greatly affected people's lives. In terms of glaucoma, glaucoma is the world's first irreversible blinding eye disease, and its most important risk factor is pathological elevated intraocular pressure. Therefore, real-time intraocular pressure monitoring is of great significance for the diagnosis and treatment of glaucoma. According to the survey until 2010, there were about 67 million glaucoma patients in the world, and about 15 million glaucoma patients in China. It is estimated that by 2020, the number of glaucoma patients in the world will increase to 79.6 million, while the number of glaucoma patients in China wil...

Claims

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Application Information

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IPC IPC(8): A61B3/16G02B1/00
CPCA61B3/16A61B2562/0247A61B2562/028A61B2562/0285G02B1/005
Inventor 杜学敏王娟崔欢庆
Owner SHENZHEN INST OF ADVANCED TECH
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