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Hydroxydihydropervolactone in purslane and its extraction and separation method

A technology for the separation of hydroxydihydropervolactone and its separation method in purslane, which is applied in the field of hydroxydihydropervolactone and its extraction and separation, and can solve the problem of α-β-unsaturated γ-lactone compounds that have not been seen Separation and other issues, to achieve the effect of simple and fast operation method, significant anti-tumor activity and anti-HIV activity, and environmentally friendly process method

Active Publication Date: 2018-11-20
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, many scholars have focused on the content determination of the chemical components of purslane, pharmacodynamics and pharmacokinetics research, however, never seen in purslane α-β-unsaturated γ-lactone compounds Separation and in vivo and in vitro analysis research reports

Method used

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  • Hydroxydihydropervolactone in purslane and its extraction and separation method
  • Hydroxydihydropervolactone in purslane and its extraction and separation method
  • Hydroxydihydropervolactone in purslane and its extraction and separation method

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Embodiment 1

[0028] This embodiment provides a kind of hydroxydihydropervolactone, molecular formula is C 11 h 18 o 3 , the chemical structural formula is.

[0029]

[0030] The hydroxydihydropervolactone is named 5-hydroxy-3,4-dimethyl-5-pentanyl-2(5H)-furanone according to the structure, and Table 1 shows the NMR of the unsaturated lactone compound data: 1 H-NMR with 13 C-NMR in CDCl 3 middle.

[0031] Table 1: NMR data of hydroxydihydropervolactone.

[0032]

[0033] Compound: Pale yellow oil; HR-ESI-TOF-MS gave m / z: 199.1321 [M+H] + The quasi-molecular ion peak (see figure 1 ), the molecular weight is 198.1404; 1 H-NMR, 13 C-NMR and DEPT data (see Figure 2-4 ), it is speculated that the possible molecular formula of this compound is C 11 h 18 o 3 , the degree of unsaturation is 3; the spectral data are as follows, 1 H-NMR (500MHz, CDCl 3 ) δ: 1.96 (1H, br, H-6a), 1.93 (3H, d, J=0.75Hz, H-11), 1.81 (3H, d, J=0.85 Hz, H-12), 1.77 (1H, br, H-6b), 1.29 (2H, m, H-8,...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to hydroxydihydrobovolide extracted, separated and identified from portulaca oleracea for the first time, and an extraction and separation method of the hydroxydihydrobovolide. The molecular formula of the hydroxydihydrobovolide is C11H18O3 and the hydroxydihydrobovolide is named as 5-hydroxy-3,4-dimethyl-5-pentyl-2(5H)-furanone. The invention also provides an extraction and separation method of the unsaturated lactone compound. The alpha-beta-unsaturated gamma-lactone compound, namely the hydroxydihydrobovolide, is extracted and separated from the portulaca oleracea successfully for the first time by sequentially adopting 50 percent ethanol reflux extraction, macroporous adsorption resin chromatography, ethyl acetate extraction, polyamide column chromatography, silica gel column chromatography, ODS (octadecylsilyl) medium-pressure column separation as well as Sephadex LH-20 separation and purification; and the hydroxydihydrobovolide has anti-inflammatory and neuroprotective effects. The hydroxydihydrobovolide and derivatives thereof can serve as primers for synthesis of other compounds and serve as raw materials for new medicine development and pharmacological activity research to be used for preparing anti-inflammatory and neuroprotective medicines or health-care products.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to hydroxydihydropervolactone extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] purslane( Portulaca oleracea L.), also known as long-lived vegetable and horse amaranth, is a plant of the family Portulaca oleracea. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [0003] Modern pharmacological studies of purslane have shown that it has the functions of anti-inflamm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/60A61P29/00A61P25/00
CPCA23L33/105A23V2002/00A61P25/00A61P29/00A61P31/18A61P35/00C07D307/60A23V2200/308A23V2200/322A23V2200/30A23V2250/21
Inventor 英锡相张文洁英哲铭徐靓杨旭
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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