Preparation method of water-soluble high-molecular cyclodextrin polymer

A technology of cyclodextrin polymer and water-soluble polymer, which is applied in the field of preparation of water-soluble polymer cyclodextrin polymer, can solve the problems such as the inability to apply drug compatibilization, and achieves high practical value, high water solubility, and inclusion. powerful effect
CN106589169AInactive Publication Date: 2017-04-26JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2017-04-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a water-soluble high-molecular cyclodextrin polymer, and belongs to the field of chemical modification of cyclodextrin. The method comprises the following steps: activating hydroxyl groups in alkaline environment, and carrying out nucleophilic substitution on chloropropylene oxide and a hydroxyl group activated solution used as a nucleophilic agent; terminating the above reaction when the reaction time is reached; and adjusting the obtained reaction system to be neutral, carrying out alcohol precipitation and water washing purification on the obtained product, and drying the purified product to obtain the water-soluble high-molecular cyclodextrin polymer. The obtained cyclodextrin polymer has high weight average molecular weight reaching 10<7> Da, and has high water solubility of 500 g / L or above, so the cyclodextrin polymer obtained in the invention is better than reported cyclodextrin polymers. The cyclodextrin polymer structurally reserves the cavity of cyclodextrin, also has high-molecular effects, has strong inclusion capability to guests, and has high practical values in the field of insoluble substance solubilizing.
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Description

technical field

[0001] The invention relates to the technical field of cyclodextrin chemical modification, in particular to a preparation method of a water-soluble cyclodextrin polymer with a molecular weight up to 10E7. Background technique

[0002] Cyclodextrin has the characteristics of being hydrophilic on the outside and hydrophobic on the inside, and can be widely used in the solubilization and microencapsulation of insoluble substances. However, the parent cyclodextrin forms internal hydrogen bonds, resulting in its own low water solubility, which limits its application. At present, there are mainly two technical paths to improve the water solubility of cyclodextrin. One is to add derivative groups to the parent cyclodextrin to break the internal hydrogen bonds, such as hydroxypropyl cyclodextrin and sulfobutyl cyclodextrin. The second is to cross-link cyclodextrin into a polymer.

[0003] Cyclodextrin polymer not only has polymer effect, but also retains the inclus...

Claims

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