A vascular stent for preventing vascular restenosis and its preparation method

Abstract

The invention relates to medical supplies, and in particular relates to an intravascular stent capable of preventing vascular restenosis and a preparation method of the intravascular stent. The intravascular stent capable of preventing vascular restenosis comprises support units and connecting units arranged along the axial direction, wherein the adjacent support units are connected through the connecting units; the support units are defined as large support units, middle support units and small support units according to the sizes of covering areas, the middle support units are arranged on two sides of the large support units in the horizontal direction, the large support units and the small support units are arranged on two sides of the middle support units, and the middle support units are arranged on two sides of the small support units; PLA bio-degradable films cover the surface of the stent, two layers of PLA bio-degradable films are available, radioactive elements are arranged between the two layers of PLA bio-degradable films, and the radioactive elements are uniformly distributed in dexamethasone gel; a medicine infiltrates the surfaces of the PLA bio-degradable films. The intravascular stent is reasonable in structure and good in support effect, and vascular restenosis can be effectively prevented.

Description

technical field [0001] The invention relates to a medical product, in particular to a blood vessel stent capable of preventing blood vessel restenosis and a preparation method thereof. Background technique [0002] In 1964, Dotter and Judkings proposed the concept of percutaneous transluminal angioplasty, and assumed the use of silicone rubber or plastic to support blood vessels to maintain smooth blood flow in the vascular lumen. In 1987, Siwart et al. used intravascular metal stents for the first time in coronary arteries, which provided a good way for the treatment of vascular occlusion diseases. An ideal vascular stent should have the following characteristics: (1) Better biocompatibility: minimal procoagulant effect, less likely to cause coagulation reaction and thrombus after implantation, less likely to cause vascular wall inflammation and intimal hyperplasia; 2) easy positioning; (3) good flexibility, easy to push to the lesion; (4) easy to expand, strong support an...

AI Technical Summary

Problems solved by technology

[0004] However, in the way of drug loading of existing stents, one is to mix the drugs in various gels and coat them on the surface of the stents. This coating method has the disadvantage of unstable coating; for this reason, many stents are made Improvements have been made, such as processing several micropores on the surface of the stent and filling the micropores with drugs, but uniformly processing micropores on the surface of the stent is difficult to process; the drug-loaded adhesion effect is poor

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