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Self-microemulsion nutrient composition containing coenzyme Q10 and preparation method and application

A nutritional composition and self-microemulsion technology, which can be applied to medical preparations containing active ingredients, drug combinations, and medical preparations without active ingredients, etc., can solve problems such as low oral bioavailability, and achieve good absorption in vivo. , to ensure safety and efficacy, to improve the effect of bioavailability

Active Publication Date: 2017-05-10
XIAMEN KINGDOMWAY BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But curcumin, like Q10, is almost insoluble in water, and its oral bioavailability is very low

Method used

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  • Self-microemulsion nutrient composition containing coenzyme Q10 and preparation method and application
  • Self-microemulsion nutrient composition containing coenzyme Q10 and preparation method and application
  • Self-microemulsion nutrient composition containing coenzyme Q10 and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Table 1 embodiment 1-6 each component consumption table

[0045]

[0046]

[0047] Table 2 embodiment 7-13 each component consumption table

[0048]

[0049]

[0050] Preparation method: Weigh each component according to the mass parts listed in Table 1, mix the other components except coenzyme Q10 and curcumin evenly, then add coenzyme Q10 and curcumin, heat to 55°C and stir until the whole system is uniform and transparent , and then keep warm for 30 minutes, and after cooling down to normal temperature, an orange-yellow transparent and uniform self-micro-emulsifying oil agent is obtained.

[0051] Take about 1g of microemulsified oil and add it into 100ml of deionized water, and shake it slightly to obtain an orange-yellow transparent water emulsion, which shows that the product has good water dispersibility.

[0052] (1) The obtained coenzyme Q10-curcumin soft capsules are obtained from the microemulsified oil through the soft capsule production equipme...

Embodiment 2

[0055] Raw materials: see Table 1.

[0056] Preparation method: Weigh each component according to the mass parts listed in Table 1, mix the other components except coenzyme Q10 and curcumin evenly, then add coenzyme Q10 and curcumin, heat to 50°C and stir until the whole system is uniform and transparent , and then keep warm for 40 minutes, and after cooling down to normal temperature, an orange-yellow transparent and uniform self-micro-emulsifying oil agent is obtained.

[0057] Take about 1g of microemulsified oil and add it into 100ml of deionized water, and shake it slightly to obtain an orange-yellow transparent water emulsion, which shows that the product has good water dispersibility.

[0058] (1) Obtain coenzyme Q10-curcumin soft capsules through soft capsule production equipment.

[0059] (2) Self-microemulsion microcapsules were prepared according to the microcapsule preparation process of Example 1.

Embodiment 3

[0061] Raw materials: see Table 1.

[0062] Preparation method: Weigh each component according to the mass parts listed in Table 1, mix the other components except coenzyme Q10 and curcumin evenly, then add coenzyme Q10 and curcumin, heat to 60°C and stir until the whole system is uniform and transparent , and then keep warm for 50 minutes, and after cooling down to normal temperature, an orange-yellow transparent and uniform self-micro-emulsifying oil agent is obtained.

[0063] Take about 1g of microemulsified oil and add it into 100ml of deionized water, and shake it slightly to obtain an orange-yellow transparent water emulsion, which shows that the product has good water dispersibility.

[0064] (1) Obtain coenzyme Q10-curcumin soft capsules through soft capsule production equipment.

[0065] (2) Self-microemulsion microcapsules were prepared according to the microcapsule preparation process of Example 1.

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Abstract

The invention discloses a self-microemulsion nutrient composition containing coenzyme Q10 and a preparation method and application. The self-microemulsion nutrient composition comprises the following components in parts by weight: 1-15 parts of coenzyme Q10, 1-15 parts of curcumin, 10-50 parts of carrier oil, 15-75 parts of a nonionic surfactant, 1-5 parts of a cationic gemini surfactant, 5-30 parts of a cosurfactant and 0-2 parts of an antioxidant, wherein the components are prepared into a uniform, stable, clear and transparent solution. The self-microemulsion nutrient composition has good stability, crystallization of coenzyme Q10 is remarkably inhibited, and the product shelf life is prolonged. In the application process, the composition can be simply and conveniently added into systems of water-phase food, medicines and the like according to demand amounts, and is safe and effective. Meanwhile, the whole preparation process is green, environmental-friendly, low in energy consumption and easy in industrial production.

Description

technical field [0001] The invention relates to the field of compositions, in particular to a self-microemulsion nutritional composition containing coenzyme Q10, a preparation method and application. Background technique [0002] Parkinson's disease (PD) is a chronic degenerative disease of the nervous system that mainly occurs in middle-aged and elderly people. Severe non-motor symptoms, such as cognitive impairment, sleep disturbance, depressive symptoms, and autonomic dysfunction, not only seriously reduce the quality of life of patients, but also bring a heavy burden to families and society. With the increasingly serious aging problem of my country's population structure, the incidence of Parkinson's disease is also increasing significantly year by year, and Parkinson's disease has become the main killer affecting the health of the elderly. Therefore, actively developing safe and effective drugs and preparations for preventing or treating Parkinson's disease has become ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K31/12A61K9/107A61K47/44A61K47/14A61K47/50A61P25/16A23L33/10
CPCA23V2002/00A61K9/1075A61K31/12A61K31/122A61K47/14A61K47/44A61K2300/00A23V2200/322
Inventor 王雪瑞朱林静陈中科陈芳芳
Owner XIAMEN KINGDOMWAY BIOTECH CO LTD
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