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Perinereis aibuhitensis anticoagulation peptide and use thereof

A technology of double-toothed nereis and anticoagulant peptides, which is applied in the field of active peptides to achieve good medical application value and good anticoagulant activity

Active Publication Date: 2017-05-10
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extracting anticoagulant components from clam worms by enzymatic hydrolysis to inhibit thrombus in vivo has not been reported

Method used

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  • Perinereis aibuhitensis anticoagulation peptide and use thereof
  • Perinereis aibuhitensis anticoagulation peptide and use thereof
  • Perinereis aibuhitensis anticoagulation peptide and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] 1 Materials and methods

[0041] 1.1 Animals, materials and reagents

[0042] Healthy male clean-grade ICR mice, body weight (20±2) g; healthy male clean-grade SD rats, body weight (140±10) g, purchased from Zhejiang Academy of Medical Sciences, animal production license number: SCXK (Zhejiang )2014-0001.

[0043] The clam worm was purchased from Zhujiajian, Zhoushan, Zhejiang, and was identified by Professor Zhao Shenglong from Zhejiang Ocean University.

[0044] Trypsin, alkaline protease, neutral protease, papain, pepsin China Asia-Pacific Hengxin Company; fibrinogen, thrombin, carrageenan, ADP American Sigma Company; aspirin enteric-coated tablets Bayer Healthcare Co., Ltd.; others Reagents were all domestic analytically pure.

[0045] 1.2 Instruments and equipment

[0046] Cogent u Scale ultrafiltration system Merck Millipore; ApurifierUPC100 fast protein liquid chromatography system GE Healthcare; ALPHA1-4 freeze dryer Christ company of Germany;

[0047] Agil...

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PUM

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Abstract

The invention discloses a perinereis aibuhitensis anticoagulation peptide and use thereof. The amino acid sequence of the perinereis aibuhitensis anticoagulation peptide is Pro-Val-Glu-Arg-Lys. The perinereis aibuhitensis anticoagulation peptide is high in anticoagulation activity, has an antithrombus effect, and has a preferable medical application value.

Description

technical field [0001] The present invention relates to an active peptide, in particular to an anticoagulant peptide and its application. Background technique [0002] Thrombosis is the common pathological basis of ischemic heart disease, ischemic stroke and venous thrombosis, which seriously endangers human health and has been increasing in recent years. Inhibition of platelet aggregation and release, inhibition of thrombin system, activation of antithrombin and plasmin system can inhibit thrombus formation. The formation of thrombus is the main pathological process of ischemic cardiovascular and cerebrovascular diseases and thromboembolic diseases, and is closely related to the occurrence and development of diseases. Therefore, inhibiting platelet aggregation and thrombus formation is of great significance to the prevention and treatment of cardiovascular and cerebrovascular diseases and other thromboembolic diseases. [0003] Perinereis aibuhitensis belongs to the kingd...

Claims

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Application Information

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IPC IPC(8): C07K7/06C12P21/06C07K1/34C07K1/20C07K1/18C07K1/16A61K38/08A61P7/02A23L33/18
CPCA23V2002/00A61K38/00C07K7/06C12P21/06A23V2200/30A23V2200/326A23V2250/55
Inventor 丁国芳郑媛媛杨最素贾盈露余方苗徐银峰黄芳芳唐云平
Owner ZHEJIANG OCEAN UNIV
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