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Injectable temperature-sensitive hydrogel artificial lens material having cell membrane biomimetic property and preparation method thereof

A temperature-sensitive hydrogel and cell membrane technology, applied in prostheses, tissue regeneration, pharmaceutical formulations, etc., can solve problems such as glare, post-cataract, etc., to avoid complications, reduce inflammatory reactions, resist adhesion and hyperplasia Effect

Active Publication Date: 2017-05-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the folding intraocular lens is limited by materials and implantation methods, it is easy to cause glare problems and posterior cataracts

Method used

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  • Injectable temperature-sensitive hydrogel artificial lens material having cell membrane biomimetic property and preparation method thereof
  • Injectable temperature-sensitive hydrogel artificial lens material having cell membrane biomimetic property and preparation method thereof
  • Injectable temperature-sensitive hydrogel artificial lens material having cell membrane biomimetic property and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Selected monomers: the first monomer is N-isopropylacrylamide, the second monomer is 2-phenoxyethyl acrylate, and the third monomer is 2-methacryloyloxyethyl phosphoryl chol The base, the initiator is azobisisobutyronitrile. Among them, the content of N-isopropylacrylamide is 40%, 2-phenoxyethyl acrylate is 40%, 2-methacryloyloxyethyl phosphorylcholine is 19%, and azobisisobutyronitrile is 1%. . The polymerizable monomer and the initiator were mixed uniformly under the protection of nitrogen and injected into the glass mold, heated and polymerized in an oven at 60ºC for 18 hours, then the temperature was raised to 90ºC, and the reaction was continued for 6 hours. Put the glass mold in deionized water at 40 ºC for swelling balance, and the polymer material is demoulded. During this period, the unreacted small molecular monomers are removed by replacing the deionized water, and finally a temperature-sensitive polymer material that can be used as an intraocular lens mater...

Embodiment 2

[0031] Selected monomers: the first monomer is vinylpyrrolidone, the second monomer is 2-phenoxyethyl methacrylate, the third monomer is 2-methacryloyloxyethyl phosphorylcholine, The initiator is azobisisobutyronitrile. Among them, the content of vinylpyrrolidone is 40%, 2-phenoxyethyl methacrylate is 45%, 2-methacryloyloxyethyl phosphorylcholine is 14%, and azobisisobutyronitrile is 1%. The polymerizable monomer and initiator were mixed evenly under the protection of nitrogen and then injected into a glass mold, heated and polymerized in an oven at 70 ºC for 8 hours, and then the temperature was raised to 100 ºC to continue the reaction for 12 hours. The glass mold was placed in deionized water at 40 ºC for swelling balance, and the polymer was released from the mold. During this period, the unreacted small molecular monomers were removed by replacing the deionized water, and finally a temperature-sensitive polymer material that could be used as an intraocular lens material w...

Embodiment 3

[0034]Selected monomers: the first monomer is dimethylaminoethyl methacrylate, the second monomer is 2-phenoxyethyl methacrylate, and the third monomer is 2-methacryloyloxyethyl Phosphorylcholine, the initiator is azobisisobutyronitrile. Among them, the content of dimethylaminoethyl methacrylate is 43%, 2-phenoxyethyl methacrylate is 42%, 2-methacryloyloxyethyl phosphorylcholine is 14%, azobisisobutyl Nitrile 1%. The polymerizable monomer and the initiator were mixed uniformly under the protection of nitrogen and injected into the glass mold, heated and polymerized in an oven at 60 ºC for 16 hours, and then the temperature was raised to 100 ºC to continue the reaction for 8 hours. The glass mold was placed in 40ºC deionized water for swelling balance, and the polymer was released from the mold. During this period, unreacted small molecular monomers were removed by replacing the deionized water, and finally a temperature-sensitive polymer material that could be used as an intr...

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Abstract

The invention discloses an injectable temperature-sensitive hydrogel artificial lens material having a cell membrane biomimetic property and a preparation method thereof, and belongs to the field of biomedical materials. The material is prepared through free radical polymerization of polymerizable monomers and an initiator, wherein the polymerizable monomers are divided into three classes; the first class comprises N-isopropylacrylamide, vinyl pyrrolidone, 2-(Dimethylamino)ethyl methacrylate or other temperature-sensitive functional monomers; the second class comprises 2-phenoxyethyl methacrylate or 2-phenoxyethyl acrylate; the third class comprises 2-methylacryloyloxyethyl phosphorylcholine; and the initiator is azodiisobutyronitrile. The material is temperature-sensitive and has favorable water solubility and flowability at low temperature, thereby being beneficial to injection operation; the material can be gelated within the temperature range of a human body, and has favorable mechanical and optical properties; and the artificial lens has the characteristic of cell membrane biomimetic property, has favorable biocompatibility and can reduce the proliferation of human epithelial cells on the surface of the artificial lens, so that surgical incisions are effectively decreased through an injection means.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a cell membrane bionic injectable temperature-sensitive hydrogel intraocular lens material and a preparation method thereof. [0002] technical background [0003] Cataract is a common middle-aged and elderly eye disease. It mainly manifests as opacity of the lens itself or the lens capsule. Clinically, surgery can only be used to restore vision to the patient, that is, cataract extraction and intraocular lens implantation. Intraocular lenses have been used clinically for decades and are mainly composed of polymers and cross-linking agents. By changing the chemical composition of the polymer, the refractive index, hardness and other properties of the intraocular lens can be changed. According to its hardness, it can be divided into hard intraocular lens and soft intraocular lens, and soft intraocular lens is also called foldable intraocular lens. The main material of rigid in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/54C08F220/30C08F226/10C08F230/02C08F220/34A61L27/16A61L27/50A61L27/52
CPCA61L27/16A61L27/50A61L27/52A61L2400/06A61L2430/16C08F220/30C08F220/301C08F220/34C08F220/54C08L33/14C08L33/24C08F230/02C08F226/10
Inventor 王海波刘公岩聂宇张兴栋
Owner SICHUAN UNIV
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