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Thrombin time detection reagent

A technology for thrombin time and detection reagents, applied in the biological field, can solve problems such as poor stability and repeatability, and achieve the effects of reliable use, good repeatability and stability, and reduced medical costs

Active Publication Date: 2017-05-10
BEIJING SICCEEDER TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, commercial thrombin time detection reagents containing calcium ions have problems of poor stability and repeatability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The clotting time detection reagent of the present embodiment comprises bovine thrombin 4IU / mL, calcium chloride 0.55%, HEPES 1%, NaN 3 1‰, peptone 2%; the rest is pure water.

[0035] If it needs to be stored for a long time, it needs to be made into a freeze-dried product, and then reconstituted according to this concentration when used.

Embodiment 2

[0037] The coagulation time detection reagent of the present embodiment comprises bovine thrombin 3IU / mL, calcium chloride 0.25%, HEPES0.5%, NaN 3 0.5‰, peptone 1%; the rest is pure water.

Embodiment 3

[0039] The coagulation time detection reagent of the present embodiment comprises bovine thrombin 6IU / mL, calcium chloride 0.75%, HEPES 2%, NaN 3 2‰, peptone 3%; the rest is pure water.

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Abstract

The invention belongs to the field of biotechnology, and especially relates to a thrombin time detection reagent. The thrombin time detection reagent comprises thrombin, HEPES, NaN3, peptone, and calcium chloride. Ca2+ is added into a buffer solution to stimulate in vivo blood coagulation environment based on study on reaction mechanism, so that the thrombin time detection reagent is relatively high in clinical application value. The buffer solution ingredient in the thrombin time detection reagent is capable of realizing stabilization of thrombin reagent for 7 days after redissolving at 37 DEG C, and the stability of the thrombin time detection reagent is higher than that of commercially available reagents. In hospitals of different levels, the thrombin time detection reagent is reliable and convenient to use, waste is reduced, and medical cost is reduced.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a thrombin time detection reagent. Background technique [0002] Coagulation is a complex physiological process involving a series of coagulation factors. The coagulation system includes two aspects of coagulation and anticoagulation. The dynamic balance of the two is the key to maintaining blood flow in the body and preventing blood loss. The process of transforming into a gel state. The lack of anticoagulant substances in the body or abnormal fibrinolysis will lead to the formation of thrombus. In today's society, with the acceleration of the aging process of the population, various thrombotic diseases have increasingly become factors that affect the quality of human life, especially heart, Cerebrovascular thrombotic diseases, so there is a need for an in vitro diagnostic reagent that can provide reliable diagnostic results for the diagnosis and treatment of clinical thrombosis an...

Claims

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Application Information

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IPC IPC(8): G01N33/49
CPCG01N33/4905
Inventor 丁重辉闫君
Owner BEIJING SICCEEDER TECH CO LTD
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