Broad-spectrum anti-tumor compound preparation

A compound preparation and anti-tumor technology, applied in the field of broad-spectrum anti-tumor compound preparations, can solve problems such as non-specific resistance of tumors, and achieve the effects of strong tumor inhibition, simple production method, and increased sustained release and stability.

Inactive Publication Date: 2017-05-17
孙仁娥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, cancer has great heterogeneity and dynamics, and the immune mechanism (immune cells, immune proteins, cytokines) against cancer cells should a...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The composition of the broad-spectrum anti-tumor compound preparation in this example (the content is calculated by weight percentage) is: 5% suspension of Bacillus pertussis, 5% suspension of Bacillus diphtheriae, 5% suspension of Bacillus tetani, streptococcus Suspension 2%, Bacillus typhi suspension 2%, Bacillus paratyphi A suspension 2%, Bacillus paratyphi B suspension 2%, Salmonella suspension 2%, Staphylococcus aureus 5 % and Serratia suspension 2%; excipients include 25% fat emulsion, 0.5% polyinosinic acid, 1% lecithin, 10% dextran and 5% oil for injection, and the rest is supplemented by normal saline to 100ml capacity.

Embodiment 2

[0032] The composition of the broad-spectrum anti-tumor compound preparation in this example (the content is calculated by weight percentage) is: 6% of the suspension of Bacillus pertussis, 6% of the suspension of Bacillus diphtheriae, 10% of the suspension of Bacillus tetani, and 10% of the suspension of Streptococcus Suspension liquid 3%, Staphylococcus aureus suspension liquid 5%; excipients include fat emulsion 35%, polyinosinic acid 0.5%, lecithin 3%, dextran 25% and oil for injection 6%, the rest Make up to 100ml volume with normal saline.

Embodiment 3

[0034] The composition of the broad-spectrum anti-tumor compound preparation in this example (the content is calculated by weight percentage) is: 6% of the suspension of Bacillus pertussis, 7% of the suspension of Bacillus diphtheriae, 8% of the suspension of Bacillus tetani, and 8% of the suspension of Bacillus typhi. Suspension 3%, Bacillus paratyphi A suspension 3%, Bacillus paratyphi B suspension 3%, Salmonella suspension 5%, Staphylococcus aureus suspension 8% and Serratia suspension 2%; excipients include 28% fat emulsion, 0.2% polyinosinic acid, 3% lecithin, 15% dextran and 8% oil for injection, and the remaining amount is made up to 100 ml by normal saline.

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PUM

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Abstract

The invention relates to a broad-spectrum anti-tumor compound preparation, and belongs to the technical field of medical preparations. The broad-spectrum anti-tumor compound preparation is prepared by compounding a bacterial suspension formed by a plurality of bacteria and an auxiliary material, wherein the bacterial suspension comprises any one or more of bordetella pertussis, diphtheria bacillus, clostridium tetani, streptococcus, typhoid bacillus, bacillus paratyphosus A, bacillus paratyphosus B, salmonella enteritidis, rubella bacteria, measles bacteria, dothienesis bacterial suspension, staphylococcus aureus and serratia marcescens; or the bacterial suspension is a combination of one or more of bordetella pertussis bacterial suspension, a corynebacterium diphtheria bacterial suspension, a clostridium tetani bacterial suspension, a streptococcus bacterial suspension, a typhoid bacillus bacterial suspension, a bacillus paratyphosus A bacterial suspension, a bacillus paratyphosus B bacterial suspension, a salmonella enteritidis bacterial suspension, a rubella bacteria bacterial suspension, a measles bacteria bacterial suspension, a dothienesis bacterial suspension bacterial suspension, a staphylococcus aureus bacterial suspension and a serratia marcescens bacterial suspension. The broad-spectrum anti-tumor compound preparation has the advantages of spectrum property, good tumor killing effect and the like when being applied to anti-tumor treatment.

Description

technical field [0001] The invention relates to a broad-spectrum anti-tumor compound preparation, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Cancer has become the "first killer" of human beings. The "Global Cancer Report 2014" published by the World Health Organization (WHO) is under the responsibility of the International Cancer Research Center (IARC), the official cancer agency under the WHO, and more than 250 scientists from more than 40 countries participated in the compilation. The overall situation and prevalence trends of 28 cancers in the country were comprehensively described and analyzed. The report predicts that global cancer cases will show a rapid growth trend, from 14 million in 2012 to 19 million in 2025 and 24 million in 2035. [0003] WHO Director-General Margaret Chan said the overall impact of cancer would "undoubtedly" hit developing countries the hardest. As the living standards of people in more...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K35/744A61K35/74A61K47/34A61K47/36A61K47/24A61K47/44A61P35/00
CPCA61K9/0019A61K9/10A61K35/74A61K35/744A61K47/24A61K47/34A61K47/36A61K47/44A61K2300/00Y02A50/30
Inventor 孙仁娥徐宏汇於仁爱
Owner 孙仁娥
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