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Silk protein dental implant and preparation method thereof

A technology of silk protein and dental implants, which is applied in the fields of medical science and prostheses, can solve problems such as low compatibility of human tissue and insufficient strength of dental implants, and achieve good environment and human adaptability, good human affinity, and good The effect of compatibility

Active Publication Date: 2017-05-17
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above situation, the purpose of the present invention is to provide a silk protein dental implant and its preparation method, which is used to solve the problems of insufficient dental implant strength and low compatibility with human tissue in the prior art

Method used

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  • Silk protein dental implant and preparation method thereof
  • Silk protein dental implant and preparation method thereof
  • Silk protein dental implant and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Such as figure 1 As shown, the present invention provides a kind of preparation method of silk protein-based capsule, and concrete preparation steps are:

[0040] First, step S1 is performed to prepare a silk protein solution.

[0041] The specific method for preparing the silk protein microneedle is:

[0042] 1) Heat the cocoons in sodium carbonate solution to degumming and form silk.

[0043] As an example, the concentration of the sodium carbonate solution is 0-100 g / L, and the mass ratio of the added cocoon to the sodium carbonate solution is 10:(1-100) g / L. The heating method is electric furnace heating or pressure cooker heating, the heating temperature is 50-120°C, and the heating time is 1s-1000h. By adjusting the process parameters of the degumming process, the molecular weight of silk protein can be controlled.

[0044] 2) Washing the silk in ultrapure water, repeating several times, and drying.

[0045] As an example, the washing in this step may be stir...

Embodiment 2

[0060] What this embodiment prepares is silk protein dental implant.

[0061] Such as Figure 2 to Figure 5 As shown, 1 is a silk protein solution, 2 is a silk protein rod, 3 is a silk protein implant, and 4 is a silk protein implant including a ceramic crown. The specific implementation steps include:

[0062] First execute step S1: figure 2 As indicated, silk protein solution 1 was prepared.

[0063] Specifically, in this embodiment, first, each portion of 10g silkworm cocoon is cut into pieces and placed in 4L of sodium carbonate solution with a concentration of 2g / L, heated to boil in an electric furnace and magnetically stirred at a speed of 200r / min, and the heating time is 0.5h .

[0064] Then, each portion of boiled silk is placed in 2L of ultrapure water, stirred, washed and kneaded dry, repeated 6 times, and then dried, the stirring speed is 200r / min, and the stirring time is 20min. The volume of ultrapure water changed each time is 2L, the drying method is 25°...

Embodiment 3

[0073] In this example, zirconia ceramic powder doped silk protein dental implants were prepared.

[0074] The specific implementation steps include:

[0075] First, step S1 is performed: preparing a silk protein solution.

[0076] Specifically, in this embodiment, first, each portion of 10g silkworm cocoon is cut into pieces and placed in 4L of sodium carbonate solution with a concentration of 2g / L, heated to boil in an electric furnace and magnetically stirred at a speed of 200r / min, and the heating time is 0.5h .

[0077] Then, each portion of boiled silk is placed in 2L of ultrapure water, stirred, washed and kneaded dry, repeated 6 times, and then dried, the stirring speed is 200r / min, and the stirring time is 20min. The volume of ultrapure water changed each time is 2L, the drying method is 25°C and normal pressure (0.1MPa).

[0078] Next, immerse the dried silk in a lithium bromide solution with a concentration of 0.98 g / mL, the volume of the lithium bromide solution...

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Abstract

The invention provides a silk protein dental implant and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing a silk protein solution; secondly, concentrating the silk protein solution, drying the concentrated silk protein solution in a die, demolding, and obtaining a silk protein bar by a cutting process; finally, cutting the silk protein bar into the dental implant, and also bonding a high-hardness dental crown on the surface of the dental implant. By adjusting the molecular weight, curing parameters and forming means and doping solid-phase reinforced particles, mechanical properties of silk protein can be adjusted and controlled, and further different clinical demands are met. The silk protein dental implant provided by the invention has no toxic or side effects on a human body, is well compatible with human tissues, and can be used for replacing traditional dental implants prepared from metal materials, ceramic materials and polymer materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a silk protein dental implant and a preparation method thereof. Background technique [0002] Dental implants, also known as the third set of teeth in humans, are a way to restore missing teeth based on the lower structure implanted in bone tissue to support and retain the upper tooth restoration. It consists of two parts, the lower supporting implant and the upper dental restoration. Artificial materials (such as metal, ceramics, etc.) are used to make implants (generally similar to tooth roots), which are surgically implanted into tissues (usually the upper and lower jaws) and obtain firm retention support of bone tissue, through special devices and methods Connection to support the upper dental restoration. Dental implants can achieve a restoration effect that is very similar to natural teeth in terms of function, structure, and aesthetics, and have become the pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/50
Inventor 不公告发明人
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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