Composite bone tissue repair material and preparation method thereof

A technology for repairing materials and bone tissue, applied in tissue regeneration, prostheses, medical science, etc., can solve problems such as self-inflicted pain, side effects, and self-healing ability limitations, and achieve the goals of preventing wound inflammation, easy operation, and good porosity Effect

Inactive Publication Date: 2017-05-24
福州市大福瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Small defects in human bone tissue can be regenerated through self-healing ability, but this self-healing ability is limited by age, disease and other factors
Bone implantation is an effective artificial repair method, but autologous bone grafts bring their own pain and other side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Dissolve 0.5g of collagen in a certain volume concentration of 0.3% malonic acid solution to obtain a collagen solution with a mass concentration of 0.5%;

[0021] 2) Add water to 0.0015g cuttlefish bone powder for ultrasonic dispersion to obtain a bone powder dispersion with a concentration of 0.5 mg / mL;

[0022] 3) Add 0.1g of hydroxyapatite to the bone meal dispersion prepared in step 2), and disperse ultrasonically for 60 minutes to obtain a mixed dispersion;

[0023] 4) Slowly add the obtained mixed dispersion into the collagen solution prepared in step 1), stir at 300r / min for 15min to make it fully mixed, add 0.2% glutaraldehyde solution after freeze-drying, and crosslink at room temperature for 2h ;

[0024] 5) The product obtained after cross-linking was washed with water and then freeze-dried to obtain the composite bone tissue repair material with a porosity of 89%.

Embodiment 2

[0026] 1) Dissolve 0.5g of collagen in a certain volume concentration of 0.3% malonic acid solution to obtain a collagen solution with a mass concentration of 0.6%;

[0027] 2) Add water to 0.0020g cuttlefish bone powder for ultrasonic dispersion to obtain a bone powder dispersion with a concentration of 0.6mg / mL;

[0028] 3) Add 0.2g of hydroxyapatite to the bone powder dispersion prepared in step 2), and disperse ultrasonically for 80 minutes to obtain a mixed dispersion;

[0029] 4) Slowly add the obtained mixed dispersion to the collagen solution prepared in step 1), stir at 400r / min for 20min, make it fully mixed, add glutaraldehyde solution with a volume concentration of 0.2% after freeze-drying, and crosslink at room temperature for 2h ;

[0030] 5) The product obtained after cross-linking was washed with water and then freeze-dried to obtain the composite bone tissue repair material with a porosity of 88%.

Embodiment 3

[0032] 1) Dissolve 0.5g of collagen in a certain volume concentration of 0.3% malonic acid solution to obtain a collagen solution with a mass concentration of 1.0%;

[0033] 2) Add water to 0.0025g cuttlefish bone powder for ultrasonic dispersion to obtain a bone powder dispersion with a concentration of 0.8 mg / mL;

[0034] 3) Add 0.3g of hydroxyapatite to the bone powder dispersion prepared in step 2), and disperse it ultrasonically for 90 minutes to obtain a mixed dispersion;

[0035] 4) Slowly add the obtained mixed dispersion to the collagen solution prepared in step 1), stir at 500r / min for 10min, make it fully mixed, add glutaraldehyde solution with a volume concentration of 0.2% after freeze-drying, and crosslink at room temperature for 3h ;

[0036] 5) The product obtained after cross-linking was washed with water and then freeze-dried to obtain the composite bone tissue repair material with a porosity of 86%.

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Abstract

The invention discloses a composite bone tissue repair material and a preparation method thereof, wherein the composite bone tissue repair material is formed by composite cross-linking of a cuttlefish bone powder, hydroxyapatite and collagen, wherein the mass ratio of the cuttlefish bone powder to hydroxyapatite to collagen is (0.3-0.5) to (20-60) to 100. The obtained tissue repair material has good porosity, has good biocompatibility, also has the effects of restraining sores and relieving pain, and is favorable for quick healing of wounds.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical composite materials, and in particular relates to a composite bone tissue repair material and a preparation method thereof. Background technique [0002] Small defects in human bone tissue can be regenerated through self-healing ability, but this self-healing ability is limited by age, disease and other factors. Bone implantation is an effective artificial repair method, but autologous bone grafts bring their own pain and other side effects. Therefore, synthetic bone repair and bone substitute materials have become the focus of attention since the 1960s. At present, constructing bone repair materials in vitro through tissue engineering to fill the defect site to treat bone tissue defects is becoming an ideal treatment method for repairing bone tissue defects. Contents of the invention [0003] The object of the present invention is to provide a composite bone tissue repair mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/54
CPCA61L27/46A61L27/54A61L2300/30A61L2300/402A61L2300/412A61L2430/02C08L89/06
Inventor 张其清袁平张瑗邢永振傅秋生
Owner 福州市大福瑞生物科技有限公司
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