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Application of simvastatin in preparation of medicine for preventing pulmonary oxygen toxicity caused by high partial pressure oxygen

A technology of simvastatin and high partial pressure, which is applied in the field of pharmaceutical preparation to achieve the effects of reducing lung inflammation, reducing protein content and reducing lung damage

Active Publication Date: 2020-04-24
NAVY MEDICINE RES INST OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no studies have proven that it can be used to prevent pulmonary oxygen toxicity

Method used

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  • Application of simvastatin in preparation of medicine for preventing pulmonary oxygen toxicity caused by high partial pressure oxygen
  • Application of simvastatin in preparation of medicine for preventing pulmonary oxygen toxicity caused by high partial pressure oxygen
  • Application of simvastatin in preparation of medicine for preventing pulmonary oxygen toxicity caused by high partial pressure oxygen

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Injection drug for experiment: use physiological saline to prepare simvastatin into a solution of 0.5-2 mg / mL, and prepare it into an injection.

[0022] Experimental animals and grouping: 50 male healthy C57BL / 6 mice, weighing 20-25 g, were purchased from Shanghai Slack Experimental Animal Co., Ltd.

[0023] The mice were randomly divided into air exposure + normal saline group, hyperbaric oxygen exposure + normal saline group, hyperbaric oxygen exposure + simvastatin 5 mg / Kg group, hyperbaric oxygen exposure + simvastatin 10 mg / Kg group, hyperbaric oxygen exposure + stimulant Vastatin 20mg / Kg group, 10 rats in each group.

[0024] Experimental method: 3 days before hyperbaric oxygen exposure, the simvastatin group was injected intraperitoneally with simvastatin (5, 10, 20 mg / kg), and the control group was injected with an equal volume of normal saline intraperitoneally. One hour after the injection on the third day, the experimental animals were placed in the animal ...

Embodiment 2

[0029] Injection drug used in experiment: simvastatin was formulated into a 2 mg / mL solution with physiological saline, and prepared into an injection.

[0030] Experimental animals and grouping: 40 male healthy C57BL / 6 mice, weighing 20 g, were purchased from Shanghai Slack Experimental Animal Co., Ltd.

[0031] Mice were randomly divided into air exposure + normal saline group, air exposure + simvastatin group, hyperbaric oxygen exposure + normal saline group, hyperbaric oxygen exposure + simvastatin group, 10 in each group.

[0032] Experimental method: 3 days before exposure to high partial pressure oxygen, the simvastatin group was intraperitoneally injected with simvastatin (20 mg / kg), and the control group was intraperitoneally injected with an equal volume of normal saline. One hour after the injection on the third day, the experimental animals were placed in the animal oxygen chamber, pressurized to 0.23 MPa, exposed to 100% oxygen for 6 hours, and decompressed out of...

Embodiment 3

[0037] Injection drug used in the experiment: simvastatin was formulated into a 2 mg / mL solution with physiological saline, and prepared into an injection. The nitric oxide synthase inhibitor (L-NAME) was formulated into 2 mg / mL injection with physiological saline.

[0038] Experimental animals and grouping: 40 male healthy C57BL / 6 mice, weighing 20 g, were purchased from Shanghai Slack Experimental Animal Co., Ltd.

[0039] The mice were randomly divided into air exposure + normal saline group, hyperbaric oxygen exposure + normal saline group, hyperbaric oxygen exposure + simvastatin group, hyperbaric oxygen exposure + simvastatin + L-NAME group, 10 in each group.

[0040]Experimental method: 3 days before hyperbaric oxygen exposure, simvastatin group and simvastatin+L-NAME group were injected intraperitoneally with simvastatin (20 mg / kg), and the control group was injected with an equal volume of normal saline intraperitoneally. One hour before hyperbaric oxygen exposure on...

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Abstract

The invention belongs to the field of medicine preparation, and in particular relates to an application of simvastatin in preparing a drug for preventing pulmonary oxygen toxicity caused by high partial pressure oxygen. Simvastatin is dissolved in normal saline to prepare a 0.5-2mg / mL injection to use. The intraperitoneal injected dose of simvastatin is 5-20mg / Kg / d, and the drug is used once a day three days before being exposed to high partial pressure oxygen. Experiments verify that simvastatin can obviously reduce pulmonary permeability caused by high partial pressure oxygen, reduce the protein level in pulmonary edema and bronchoalveolar lavage fluid, alleviate lung inflammation and reduce the proportion of lung apoptosis so as to alleviate lung damage caused by pulmonary oxygen toxicity. Moreover, the application provided by the invention provides experimental data of more reasonably applying simvastatin to prevent pulmonary oxygen toxicity caused by high partial pressure oxygen clinically.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and particularly relates to the application of simvastatin in the preparation of medicines for pulmonary oxygen poisoning caused by high partial pressure oxygen. Background technique [0002] In the clinical application of ventilators to treat patients with respiratory failure, hyperbaric oxygen treatment of decompression sickness, and oxygen breathing devices in diving operations, due to excessive ambient air pressure (or excessive diving depth), high oxygen concentration and inhalation of 60-200kPa high pressure Oxygen time is too long, exceeding the adaptability of the body, which will lead to the occurrence of pulmonary oxygen toxicity. Because the respiratory system is exposed to higher oxygen partial pressure than other organs and is more sensitive to oxygen, the lung is the main target organ of oxygen toxicity. The main clinical manifestations of pulmonary oxygen toxicity are cough, su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61P11/00A61P39/00
CPCA61K31/366
Inventor 包晓辰方以群攸璞王芳芳马骏谷爱梅
Owner NAVY MEDICINE RES INST OF PLA
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