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Application of 1,6-fructose diphosphate in preparing medicine for treating alcoholic liver damage

A technology for alcoholic liver damage and fructose diphosphate, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as FDP research that has not been found, and achieve the effect of controlling alcoholic liver damage with small side effects

Inactive Publication Date: 2017-05-31
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that FDP has a therapeutic and protective effect on the liver caused by certain drugs, but there is no research on FDP in alcoholic liver injury

Method used

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  • Application of 1,6-fructose diphosphate in preparing medicine for treating alcoholic liver damage
  • Application of 1,6-fructose diphosphate in preparing medicine for treating alcoholic liver damage
  • Application of 1,6-fructose diphosphate in preparing medicine for treating alcoholic liver damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Effect of FDP on mouse transaminase induced by alcohol

[0032] 1) Experimental instruments and materials

[0033] Alcohol is absolute ethanol when used, and FDP (purchased from Xibao Biotechnology (Shanghai) Co., Ltd., the same below) is prepared with purified water after sterilization; 3% sodium pentobarbital; Stomach acupuncture; male clean-grade ICR mice were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.; AST, ALT, TG kits (microplate method) were purchased from Nanjing Jiancheng Biotechnology Co., Ltd.

[0034] 2) Experimental steps

[0035] Take male 20±2g ICR mice and administer different concentrations of FDP, and then carry out alcohol modeling (16ml / kg), and then give the same dose of FDP as before 1 hour later, anesthetize the mice for eyeball extraction after 6 hours. Blood was centrifuged at 1750g at 4°C for 15 minutes to obtain serum, and the contents of AST, ALT, and TG in serum were detected by referring to the...

Embodiment 2

[0044] Example 2 Effect of FDP on a series of antioxidant enzymes in the liver

[0045] 1) Experimental instruments and materials

[0046] Alcohol used was absolute ethanol, and FDP was prepared with sterilized pure water; 3% sodium pentobarbital; sterilized intragastric injection needle; ultrasonic breaker; male clean ICR mice were purchased from Beijing Wei Tonglihua Experimental Animal Technology Co., Ltd.; SOD, CAT, GR, GSH-PX, GSH kits (microplate method), purchased from Nanjing Jiancheng Biotechnology Co., Ltd.

[0047] 2) Experimental steps

[0048] Take male 20±2g ICR mice and administer different concentrations of FDP, and then carry out alcohol modeling (16ml / kg), and then give the same dose of FDP as before 1 hour later, anesthetize the mice for eyeball extraction after 6 hours. Blood, then cut the abdomen to take out the liver, rinse it with normal saline first, then grind it with a glass homogenizer, then break the cells with an ultrasonic breaker, centrifuge at...

Embodiment 3

[0054] Example 3 Effect of FDP on Lipid Peroxidation of Alcohol-Induced Acute Alcoholic Liver Injury

[0055] 1) Experimental instruments and materials

[0056] Alcohol used was absolute ethanol, and FDP was prepared with sterilized pure water; 3% sodium pentobarbital; sterilized intragastric injection needle; ultrasonic breaker; male clean ICR mice were purchased from Beijing Wei Tonglihua Experimental Animal Technology Co., Ltd.; MDA kit was purchased from Nanjing Jiancheng Biotechnology Co., Ltd.

[0057] 2) Experimental steps

[0058] Take male 20±2g ICR mice and administer different concentrations of FDP, and then carry out alcohol modeling (16ml / kg), and then give the same dose of FDP as before 1 hour later, anesthetize the mice for eyeball extraction after 6 hours. After the blood, the abdomen was cut open to take out the liver, rinsed with normal saline, and then the cells were broken with an ultrasonic breaker, centrifuged at 2500 rpm for 10 minutes at 4°C, and the ...

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Abstract

The invention discloses application of 1,6-fructose diphosphate in preparing a medicine for treating alcoholic liver damage. Compared with the prior art, the application of the 1,6-fructose diphosphate disclosed by the invention finds a novel effective medicine for treating liver diseases, especially for treating alcoholic liver. The application of the FDP (1,6-fructose diphosphate) in alcoholic liver damage can effectively control the alcoholic liver damage and prevent the alcoholic liver damage from developing further. The FDP serves as an energy conditioning agent, has no other untoward effects after being dosed and is very small in side effects.

Description

technical field [0001] The invention discloses the application of fructose 1,6-diphosphate in the preparation of drugs for treating alcoholic liver damage, and belongs to the technical field of new drug applications. Background technique [0002] The liver is the central metabolic organ in the body and has extremely complex and important metabolic functions. During the complex metabolic process, the liver is often accompanied by the generation of some intermediate products with active chemical properties, which will cause oxidative damage to the liver. This is caused by alcohol, etc. Basic mechanism of injury. In my country, with the improvement of living standards and alcohol consumption, the incidence of alcoholic liver injury is increasing, and it has become the second leading cause of liver injury after viral hepatitis, seriously endangering the health of the population. [0003] Long-term and continuous alcohol intake can lead to chronic liver tissue lesions, and short...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P1/16
CPCA61K31/7024
Inventor 殷志敏吴翼飞罗兰
Owner NANJING NORMAL UNIVERSITY
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