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Method for preparing high-sensitivity pizotifen molecular imprinting electrochemical sensor

A molecular imprinting, high-sensitivity technology, applied in electrochemical variables of materials, scientific instruments, instruments, etc., can solve problems such as low sensitivity, inappropriate matching of functional monomers with template molecules and cross-linking agents, and poor cross-linking rigidity. , to achieve the effect of simple equipment, excellent sensitivity and easy production

Inactive Publication Date: 2017-05-31
GUANGXI UNIV FOR NATITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current method is not sensitive due to the inappropriate matching of selected functional monomers with template molecules and cross-linking agents, and the rigidity of cross-linking is also poor.

Method used

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  • Method for preparing high-sensitivity pizotifen molecular imprinting electrochemical sensor

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Experimental program
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Embodiment 1

[0015] 1. Treatment of glassy carbon electrodes

[0016] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0017] 2. Preparation of molecularly imprinted electrochemical sensor for phenylthiazine

[0018] Use water as a solvent to prepare 10ml of copper sulfate aqueous solution with a concentration of 0.5mol / L, and use N,N-dimethylformamide as a solvent to prepare 50ml of trimesic acid solution with a concentration of 0.05mol / L, and then take the prepared 10ml of copper sulfate aqueous solution was added dropwise to the prepared 50ml of benzenetricarboxylic acid solution at a rate of 5 drops / second, vigorously stirred at a speed of 3000 rpm during the dropwise addition, and then reacted in a 100ml hot water kettle at 118°C After cooling for ...

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Abstract

The invention discloses a method for preparing a high-sensitivity pizotifen molecular imprinting electrochemical sensor. According to the method, the high-sensitivity pizotifen molecular imprinting electrochemical sensor is prepared from pizotifen as template molecules, gentiopicroside as a functional monomer, azodiisobutyronitrile as an initiator, a copper-based metal organic frame material as a doping agent and dictamnolactone as a cross-linking agent. The analysis method is simple and practical, and defects that a conventional analysis method is complex, expensive in equipment and low in sensitivity can be overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a high-sensitivity phenylthiazine molecularly imprinted electrochemical sensor. Background technique [0002] Pizotifen (Pizotifen) indications: Pizotifen is mainly used for typical and atypical migraine, which can reduce symptoms and attack frequency, and has a significant effect, but it has no immediate relief effect on acute migraine attacks. It can also be used to treat erythromelalgia, angioedema, chronic urticaria, and atrial and ventricular premature beats. However, due to long-term use or overdose of these drugs, drowsiness, fatigue, weight gain, occasional nausea, dizziness, dry mouth, flushed face, muscle pain and other phenomena may occur. [0003] Methods for the determination of phenylthiazine include high performance liquid chromatography, chromatographic mass spectrometry, etc. However, due to the need for expensive instrum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30
CPCG01N27/26G01N27/308
Inventor 韦贻春余会成李浩
Owner GUANGXI UNIV FOR NATITIES