A starch composite hemostatic dressing of mesoporous silica microspheres

A technology of mesoporous silica and mesoporous silica, applied in medical science, bandages, absorbent pads, etc., can solve problems such as burns and wounded pain

Inactive Publication Date: 2017-06-09
TIANJIN YIYAO SCI & TECH
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  • Abstract
  • Description
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Problems solved by technology

However, zeolite hemostatic agent has a big disadvantage. While absorbing water, it will release a lot of heat,...

Method used

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Embodiment Construction

[0008] The present invention will be further described in detail below through the specific examples, the following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention with this.

[0009] A starch composite hemostatic dressing of mesoporous silicon dioxide microspheres, the preparation method of which is:

[0010] Preparation of mesoporous silica microspheres: Mesoporous silica microspheres were prepared by the sol-gel method using ethyl orthosilicate (EOS) as silicon source, triblock copolymer P123 as organic template, and hydrochloric acid as catalyst. ball. Dissolve 4g of P123 in a mixed solution of 120mL 2mol / L HCI and 30mL deionized water until clear. Add 9.2mL TEOS, dissolve and clarify, and stir at 50°C for 2h to form a stable and transparent sol. Then put the sol in a constant temperature shaking box at 37°C for aging and drying, and finally heat it up to 600°C at a heating rate of 1°C / min, and keep the tempe...

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Abstract

The invention relates to a starch composite hemostatic dressing of mesoporous silica microspheres, which adopts a sol-gel method and uses a three-block copolymer pluronic as a template agent to synthesize mesoporous silica microspheres with a pore diameter of about 5 nm. It is compounded with starch to prepare a mesoporous silicon oxide microsphere/starch composite hemostatic dressing, and the hemostatic performance of the composite material is observed through animal experiments. The mesoporous silica microsphere/starch composite material not only has strong water absorption performance, but also has obvious in vitro coagulation performance, which can significantly shorten the partial thromboplastin time and prothrombin time. The mesoporous silica microsphere/starch composite material can prevent the bleeding of the rabbit's back skin and liver injury and shorten the bleeding time, and has obvious hemostatic effect.

Description

technical field [0001] The invention belongs to the technical field of hemostatic agents, and in particular relates to a starch composite hemostatic dressing made of mesoporous silicon dioxide microspheres. Background technique [0002] Bleeding from human trauma is very common in various emergencies, and whether bleeding wounds can be quickly and effectively stopped bleeding in a short period of time is a current research hotspot. In recent years, medical hemostatic materials have attracted the attention of the medical and industrial circles, and many large pharmaceutical companies are committed to developing new hemostatic materials. During the Gulf War, the U.S. military launched a "quick-setting" hemostatic bandage, which is said to effectively reduce blood loss by 50%-80%. The purpose of using a hemostatic dressing on the surface of the tissue is to shrink and close the broken blood vessels. At present, many kinds of wound hemostatic materials have been developed. Mai...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/44A61L15/28A61L15/42
Inventor 权超
Owner TIANJIN YIYAO SCI & TECH
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