Method for cultivating vascularized bone flap

A vascular pedicle and bone flap technology, applied in the field of surgical medicine, can solve problems such as damage to the donor site and affect the treatment effect, and achieve the effect of reducing body damage and avoiding damage

Pending Publication Date: 2017-06-13
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The reported cultivation method of vascularized bone flap is innovative, but its disadvantages are also obvious: First, it needs to sacrifice the patient's latissimus dorsi, periosteum and other tissue structures with important functions inherent in the body, causing great damage to the donor site In addition, after the muscle, periosteum, etc. are transplanted to the recipient area with the cultivated vascularized bone block, it will bring additional unnecessary tissue components to the recipient area, which will affect the therapeutic effect

Method used

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  • Method for cultivating vascularized bone flap
  • Method for cultivating vascularized bone flap
  • Method for cultivating vascularized bone flap

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Embodiment

[0038] A method for cultivating vascularized bone flaps, using a vascularized enveloped flap containing a shaft cardiovascular system, in vitro, receiving blood perfusion from immunodeficiency animals or artificial perfusion system, as an incubator for vascularized bone flaps; primary culture The patient’s bone marrow mesenchymal stem cells or osteoblasts are inoculated on porous bone matrix material, wrapped in the incubator of vascularized bone flap, and the vascularized bone flap is cultivated. The steps are as follows:

[0039] (1) Embed a skin dilator under the skin of the patient to obtain a vascularized enveloped flap with axial cardiovascular system;

[0040] (2) The axial envelope flap is moved out of the body and receives blood perfusion from immunodeficiency animals or artificial perfusion system as an incubator for vascularized bone flaps;

[0041] (3) The primary culture of patient's bone marrow mesenchymal stem cells or osteoblasts is inoculated on porous bone matrix ma...

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Abstract

The invention relates to a method for cultivating a vascularized bone flap. The method comprises the following steps: performing in-vivo blood perfusion of a vascularized envelope flap with an axial blood vessel by an immunodeficient animal or an artificial perfusion system to obtain a vascularized bone flap cultivator; performing primary culture of bone marrow mesenchymal stem cells or osteoblasts, and inoculating to a porous bone matrix material; and wrapping the inside of the vascularized bone flap cultivator to cultivate a vascularized bone flap. By applying the vascularized bone flap obtained by the method provided by the invention to bone defect repairing, the body injury can be minimized.

Description

Technical field [0001] The invention relates to a method for cultivating a vascularized bone flap, which is used in surgical medicine. Background technique [0002] The repair of bone defects is a difficult clinical problem. After the commonly used iliac bone blocks, rib slices, and outer skull plates are transplanted into the recipient area, obvious necrosis occurs because of the inability to rebuild blood supply in time. Vascular pedicle autogenous bone flaps such as After free fibula transplantation, it grows fast and has less bone resorption, but it causes serious damage to the donor site and has many contraindications to surgery. Therefore, pre-cultivating vascularized bone flaps has great clinical value. In recent years, in order to avoid sacrificing the body's inherent bone flaps, some studies have used the body's inherent muscles, periosteum or sarcoid as an incubator for vascularized bone flaps, and transplanted bone matrix materials inoculated with osteoblasts into bloo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/077C12N5/0775C12M3/00C12M1/36C12M1/00A61L27/38A61L27/12A61L27/50A61L27/56
CPCA61L27/12A61L27/3821A61L27/3895A61L27/50A61L27/56C12M21/08C12M29/10C12M41/00C12M41/26C12M41/40C12N5/0654C12N5/0663A61L2430/02
Inventor 丁志穆雄铮杨君毅吴颖之
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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