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Artificial skin and preparation method thereof

A technology of artificial skin and collagen, which is applied in the field of medical devices to promote wound healing, prevent direct contact of silver with cells, and prevent excessive silver release.

Inactive Publication Date: 2017-06-16
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing artificial skin cannot prevent wound infection and promote wound healing, so it is necessary to provide a new artificial skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of silicone rubber film: Mix components A and B of silicone rubber at a ratio of 1:1, stir at 300 rpm for 10 min, and defoam. Pour it into a polytetrafluoroethylene mold, level it, place it in a vacuum drying oven, and cure it at 150°C for 2 h to obtain a silicone rubber film.

[0031] Nano-silver modified on the surface of the silicone rubber membrane: a polyacrylic acid film with a thickness of about 10 nm was deposited on the surface of the obtained silicone rubber membrane by plasma polymerization technology. Then soak it in AgNO at a concentration of 8 mmol / L 3 In solution for 1h, Ag + Combined with the carboxyl group on the molecular chain of polyacrylic acid. Then soak in 0.8 mmol / L NaBH 4 In the solution for 1 h, stirring continuously, the Ag + Restored to nano Ag particles. Then, it was washed 6 times with purified water to obtain a silicone rubber film with surface modified nano-silver.

[0032] Preparation of VEGF-loaded liposomes: Weigh 0.2...

Embodiment 2

[0037] Preparation of silicone rubber film: Mix components A and B of silicone rubber at a ratio of 1:1, stir at 300 rpm for 10 min, and defoam. Pour it into a polytetrafluoroethylene mold, level it, place it in a vacuum drying oven, and cure it at 150°C for 2 h to obtain a silicone rubber film.

[0038] Nano-silver modified on the surface of the silicone rubber membrane: a polyacrylic acid film with a thickness of about 10 nm was deposited on the surface of the obtained silicone rubber membrane by plasma polymerization technology. Then soak it in AgNO at a concentration of 10 mmol / L 3 in solution for 1 h to make Ag + Combined with the carboxyl group on the molecular chain of polyacrylic acid. Then soak in 1 mmol / L NaBH 4 In the solution for 1 h, stirring continuously, the Ag + Restored to nano Ag particles. Then, it was washed 6 times with purified water to obtain a silicone rubber film with surface modified nano-silver.

[0039] Preparation of VEGF-loaded liposomes: We...

Embodiment 3

[0043] Preparation of silicone rubber film: Mix components A and B of silicone rubber at a ratio of 1:1, stir at 300 rpm for 10 min, and defoam. Pour it into a polytetrafluoroethylene mold, level it, place it in a vacuum drying oven, and cure it at 150°C for 2 h to obtain a silicone rubber film.

[0044] Nano-silver modified on the surface of the silicone rubber membrane: a polyacrylic acid film with a thickness of about 10 nm was deposited on the surface of the obtained silicone rubber membrane by plasma polymerization technology. Then soak it in AgNO at a concentration of 11 mmol / L 3 in solution for 1 h to make Ag + Combined with the carboxyl group on the molecular chain of polyacrylic acid. Then soak in 1.1 mmol / L NaBH 4 In the solution for 1 h, stirring continuously, the Ag + Restored to nano Ag particles. Then, it was washed 6 times with purified water to obtain a silicone rubber film with surface modified nano-silver.

[0045] Preparation of VEGF-loaded liposomes: ...

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Abstract

The invention discloses artificial dermis and a preparation method of the artificial dermis. The artificial dermis comprises an upper membrane and a lower membrane that are bonded with each other, wherein the upper membrane is a silicone rubber membrane with nano silver modified on the surface; the lower membrane is a collagen compound membrane; a collagen compound comprises collagen, mucopolysaccharide and VEGF (vascular endothelial growth factor) loaded liposome; according to the upper membrane, the nano silver is modified on the silicone rubber membrane by a plasma polymerization and chemical reduction method, so that the upper membrane has an antibacterial and anti-infective function; nano-silver particles do not fall off the upper membrane easily; the silver is directly contacted with cells and has toxicity; a bonding layer between the upper membrane and the lower membrane can serve as a barrier layer and prevent excessive silver release and the silver from being directly contacted with the cells; an active VEGF is introduced into the lower membrane; the lower membrane has functions of promoting angiogenesis and wound healing; and the prepared artificial skin has good biocompatibility and degradability, as well as bioactivity and antimicrobial properties.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an artificial skin and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body. It can protect the body from the invasion of harmful substances from the outside, prevent the loss of water and electrolytes in the body, maintain the stability of the internal environment of the human body, and participate in the immune and metabolic processes of the human body. There are more than 100 million skin defect patients in the world every year, and 15 million skin defect patients in my country per year. After the skin is damaged, it mainly relies on the migration and proliferation of vascular endothelial cells and fibroblasts, and the formation of epithelial tissue and hoof tissue to complete self-repair. When the skin is damaged in a large area or seriously due to accidents or diseases such as burns and skin ulcers, the skin cannot repair...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/24A61L27/20A61L27/54A61L27/30A61L27/56A61L27/58A61L27/60
CPCA61L27/60A61L27/18A61L27/20A61L27/24A61L27/306A61L27/54A61L27/56A61L27/58A61L2300/104A61L2300/404A61L2300/412A61L2300/414A61L2420/02
Inventor 王丹妍许孟强谭荣伟佘振定
Owner SHENZHEN QIKANG MEDICAL DEVICES
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