Artificial skin and preparation method thereof

A technology of artificial skin and collagen, which is applied in the field of medical devices to promote wound healing, prevent direct contact of silver with cells, and prevent excessive silver release.

Inactive Publication Date: 2017-06-16
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing artificial skin cannot prevent wound infection and promote wound healing, so it is necessary to provide a new artificial skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of silicone rubber film: Mix components A and B of silicone rubber at a ratio of 1:1, stir at 300 rpm for 10 min, and defoam. Pour it into a polytetrafluoroethylene mold, level it, place it in a vacuum drying oven, and cure it at 150°C for 2 h to obtain a silicone rubber film.

[0031] Nano-silver modified on the surface of the silicone rubber membrane: a polyacrylic acid film with a thickness of about 10 nm was deposited on the surface of the obtained silicone rubber membrane by plasma polymerization technology. Then soak it in AgNO at a concentration of 8 mmol / L 3 In solution for 1h, Ag + Combined with the carboxyl group on the molecular chain of polyacrylic acid. Then soak in 0.8 mmol / L NaBH 4 In the solution for 1 h, stirring continuously, the Ag + Restored to nano Ag particles. Then, it was washed 6 times with purified water to obtain a silicone rubber film with surface modified nano-silver.

[0032] Preparation of VEGF-loaded liposomes: Weigh 0.2...

Embodiment 2

[0037] Preparation of silicone rubber film: Mix components A and B of silicone rubber at a ratio of 1:1, stir at 300 rpm for 10 min, and defoam. Pour it into a polytetrafluoroethylene mold, level it, place it in a vacuum drying oven, and cure it at 150°C for 2 h to obtain a silicone rubber film.

[0038] Nano-silver modified on the surface of the silicone rubber membrane: a polyacrylic acid film with a thickness of about 10 nm was deposited on the surface of the obtained silicone rubber membrane by plasma polymerization technology. Then soak it in AgNO at a concentration of 10 mmol / L 3 in solution for 1 h to make Ag + Combined with the carboxyl group on the molecular chain of polyacrylic acid. Then soak in 1 mmol / L NaBH 4 In the solution for 1 h, stirring continuously, the Ag + Restored to nano Ag particles. Then, it was washed 6 times with purified water to obtain a silicone rubber film with surface modified nano-silver.

[0039] Preparation of VEGF-loaded liposomes: We...

Embodiment 3

[0043] Preparation of silicone rubber film: Mix components A and B of silicone rubber at a ratio of 1:1, stir at 300 rpm for 10 min, and defoam. Pour it into a polytetrafluoroethylene mold, level it, place it in a vacuum drying oven, and cure it at 150°C for 2 h to obtain a silicone rubber film.

[0044] Nano-silver modified on the surface of the silicone rubber membrane: a polyacrylic acid film with a thickness of about 10 nm was deposited on the surface of the obtained silicone rubber membrane by plasma polymerization technology. Then soak it in AgNO at a concentration of 11 mmol / L 3 in solution for 1 h to make Ag + Combined with the carboxyl group on the molecular chain of polyacrylic acid. Then soak in 1.1 mmol / L NaBH 4 In the solution for 1 h, stirring continuously, the Ag + Restored to nano Ag particles. Then, it was washed 6 times with purified water to obtain a silicone rubber film with surface modified nano-silver.

[0045] Preparation of VEGF-loaded liposomes: ...

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Abstract

The invention discloses an artificial dermis and a preparation method thereof. The artificial dermis comprises two upper and lower films bonded to each other, the upper film is a silicone rubber film with nano-silver on the surface, and the lower film is a collagen composite film. The materials include collagen, mucopolysaccharides and liposomes loaded with VEGF; the upper membrane is modified with nano-silver on the silicone rubber membrane by plasma polymerization + chemical reduction, so that the upper membrane has the function of antibacterial and anti-infection, and the nano-silver particles are not easy to be removed from the upper membrane. Falling off, silver is toxic in direct contact with cells, the adhesive layer between the upper membrane and the lower membrane can be used as a barrier layer, which can prevent excessive silver release and prevent silver from directly contacting cells; the lower membrane introduces active print VEGF, It has the function of promoting angiogenesis and wound healing, and the prepared artificial skin has good biocompatibility and degradability, and has both bioactivity and antibacterial properties.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an artificial skin and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body. It can protect the body from the invasion of harmful substances from the outside, prevent the loss of water and electrolytes in the body, maintain the stability of the internal environment of the human body, and participate in the immune and metabolic processes of the human body. There are more than 100 million skin defect patients in the world every year, and 15 million skin defect patients in my country per year. After the skin is damaged, it mainly relies on the migration and proliferation of vascular endothelial cells and fibroblasts, and the formation of epithelial tissue and hoof tissue to complete self-repair. When the skin is damaged in a large area or seriously due to accidents or diseases such as burns and skin ulcers, the skin cannot repair...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/24A61L27/20A61L27/54A61L27/30A61L27/56A61L27/58A61L27/60
CPCA61L27/60A61L27/18A61L27/20A61L27/24A61L27/306A61L27/54A61L27/56A61L27/58A61L2300/104A61L2300/404A61L2300/412A61L2300/414A61L2420/02
Inventor 王丹妍许孟强谭荣伟佘振定
Owner SHENZHEN QIKANG MEDICAL DEVICES
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