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Flueggea acicularis extract, preparation method thereof and application thereof in preparation of medicament for preventing and controlling bacterial infection

A technology for the infection of rice tree and bacteria, which is applied in the direction of antibacterial drugs, preparation of organic compounds, chemical instruments and methods, etc., and can solve problems such as no reports of diterpene compounds against drug-resistant bacteria.

Inactive Publication Date: 2017-06-20
GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] No report of its diterpene compounds against drug-resistant bacteria in the prior art

Method used

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  • Flueggea acicularis extract, preparation method thereof and application thereof in preparation of medicament for preventing and controlling bacterial infection
  • Flueggea acicularis extract, preparation method thereof and application thereof in preparation of medicament for preventing and controlling bacterial infection
  • Flueggea acicularis extract, preparation method thereof and application thereof in preparation of medicament for preventing and controlling bacterial infection

Examples

Experimental program
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Embodiment 1

[0029] The method for preparing compound 1-3 from the white rice tree (Flueggea acicularis):

[0030] The whole plant of Flueggea acicularis, dried in the sun, crushed, leached three times with 95% ethanol at room temperature for 24 hours each time, combined the concentrates, extracted with ethyl acetate and n-butanol respectively to obtain ethyl acetate, n-butanol The butanol part and 76 g of the ethyl acetate part were dissolved in solvents such as acetone and then adsorbed on silica gel. After drying at room temperature, silica gel column chromatography (600 g, 200-300 mesh) was used to obtain pure dichloromethane, dichloromethane:methanol (200:1, 100:1, 50:1, 20:1 and 10:1) gradient elution gave six fractions (A-F). Fraction D (8.5g) was passed through an MCI column (methanol:water=85:15) to remove most of the pigment, then concentrated in a water bath under reduced pressure, and then repeated silica gel column chromatography (eluted with pure dichloromethane first, and th...

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Abstract

The invention discloses application of a flueggea acicularis extract in preparation of a medicament for preventing and treating bacterial infection; the flueggea acicularis extract is one of the following structural formulas. The invention further provides a preparation method of the flueggea acicularis extract, and the compounds shown in the following structural formulas are obtained from a plant flueggea acicularis for the first time according to the invention, wherein the compound 1 is a novel compound. The flueggea acicularis extract provided by the invention has a certain inhibitory effect for methicillin-resistant staphylococcus aureus and / or staphylococcus aureus and can be used for the preparation of a medicament for preventing and treating bacterial infection. The structural formulas are shown in the specification.

Description

technical field [0001] The invention belongs to the technical field of active ingredients of traditional Chinese medicines and medicines, and more specifically relates to the application of an extract from P. solanifolia and a preparation method thereof in the preparation of medicines for preventing and treating bacterial infections. Background technique [0002] Since Fleming's discovery of penicillin in 1928, antibiotics have become the main clinical drug, but it also brought about the problem of bacterial drug resistance. Hospital statistics in 2014 found that patients infected with methicillin-resistant Staphylococcus aureus had a 64% higher mortality rate than patients not infected with non-resistant Staphylococcus aureus. Drug resistance has become a major problem that seriously endangers human health. [0003] Flueggea acicularis is a plant of the genus Flueggea in the family Euphorbiaceae, which is a unique plant in China. In my country, it is mainly distributed in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P31/04C07C39/23C07C37/68C07C37/82
CPCA61K31/05C07C37/68C07C37/82C07C39/23
Inventor 顾琼徐峻罗祥坤
Owner GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK