Tumor vascular endothelial cell targeted IP10 single-chain antibody and preparation method
A single-chain antibody and tumor blood vessel technology, applied in the medical field, can solve the problems of not being able to enrich IP10, etc., and achieve the effects of inhibiting tumor growth, inhibiting cell proliferation in tumor tissue, and promoting angiogenesis
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[0037] In order to make the objectives, technical solutions, and advantages of the present invention clearer, the following further describes the present invention in detail with reference to the accompanying drawings and embodiments.
[0038] Endoglin, also known as CD105, is a cell membrane glycoprotein, which is mainly distributed on the surface of endothelial cells in neovascularization and vascular endothelial cells in tissues surrounding tumors. Therefore, Endoglin is closely related to tumor angiogenesis and is one of the landmark molecules of tumor angiogenesis. Endoglin as a tumor treatment target is superior to traditional tumor antigen binding sites, and has an attractive clinical application prospect.
[0039] Single-chain antibody (scFv) is a small peptide that connects the variable region of the heavy chain (VH) and the variable region of the light chain (VL) by a connecting peptide, which maintains the specificity and affinity of natural antibodies and can be genetic...
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