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High performance liquid chromatography assay method for formaldehyde and acetaldehyde in cigarette filter bead

A high-performance liquid chromatography, cigarette filter technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem of measuring cigarette filter burst beads, etc., achieve high sensitivity and accuracy, avoid loss of components and avoid the external environment. Contamination, simple effect of sample preparation process

Active Publication Date: 2017-06-20
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But, how to measure the residual amount of formaldehyde and acetaldehyde in cigarette filter quick-fried beads (including wall material and core material), there is no related literature report at present

Method used

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  • High performance liquid chromatography assay method for formaldehyde and acetaldehyde in cigarette filter bead
  • High performance liquid chromatography assay method for formaldehyde and acetaldehyde in cigarette filter bead
  • High performance liquid chromatography assay method for formaldehyde and acetaldehyde in cigarette filter bead

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Experimental program
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Effect test

Embodiment 1

[0034] The high-performance liquid chromatography assay method of formaldehyde and acetaldehyde in the cigarette filter quick-fried beads of the present embodiment, such as figure 1 shown, including the following steps:

[0035] 1) Preparation of 2,4-dinitrophenylhydrazine derivatization reagent

[0036] Purification of 2,4-dinitrophenylhydrazine: Weigh 12g of 2,4-dinitrophenylhydrazine into a 250mL round bottom flask, add 200mL of acetonitrile, heat to dissolve at 130°C and reflux for 2h, then transfer to a beaker and seal After standing overnight, the obtained crystals were suction filtered and washed, dried in a vacuum oven, and finally sealed in a brown bottle for future use.

[0037] Preparation of 2,4-dinitrophenylhydrazine derivatization reagent: Weigh 0.01g of purified 2,4-dinitrophenylhydrazine into a 100mL brown volumetric flask, add 5mL of phosphoric acid, and dilute to volume with acetonitrile to obtain the product.

[0038] 2) Preparation of test solution

[00...

experiment example

[0070] According to the method of embodiment 1, the cigarette filter popping beads sample is analyzed, and the obtained chromatogram is as follows Figure 5 shown, where Figure 5 The chromatographic peak at 6 is the chromatographic peak of acetaldehyde-2,4-dinitrophenylhydrazone. The recovery and precision experiments were carried out with the 3-level standard addition method, and the determination was repeated 5 times for each standard addition level. The recovery and repeatability results of the detection method are shown in Table 3. It can be seen from Table 3 that the recovery rate and repeatability data are ideal, the recovery rates of the three spiked levels are between 81.1-107.8%, and the relative standard deviation (RSD) is 0.7-1.3%, which can meet the needs of quantitative analysis.

[0071] Table 3 Detection method recovery rate and repeatability

[0072]

[0073] In other embodiments of the present invention, the preparation of the liquid to be tested can als...

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Abstract

The invention relates to a high performance liquid chromatography assay method for formaldehyde and acetaldehyde in cigarette filter beads, and belongs to the technical field of tobacco inspection. The high performance liquid chromatography assay method for formaldehyde and acetaldehyde in the cigarette filter beads comprises the following steps: 1) putting ceramic protons and a cigarette filter bead into acetonitrile, performing vortex vibration to crush the cigarette filter bead, performing derivatization treatment, and filtering so as to obtain a liquid to be tested; and 2) testing the liquid to be tested by using high performance liquid chromatography. By adopting the high performance liquid chromatography assay method for formaldehyde and acetaldehyde in the cigarette filter beads, the sample pretreatment process is simple and rapid, the analysis time can be greatly shortened, and batch samples can be conveniently analyzed; the method is high in sensitivity and accuracy, good in repeatability and applicable to detection on residues of formaldehyde and acetaldehyde in the cigarette filter beads.

Description

technical field [0001] The invention relates to a high-performance liquid chromatography method for determining formaldehyde and acetaldehyde in popcorn beads of cigarette filters, and belongs to the technical field of tobacco inspection. Background technique [0002] Formaldehyde is a kind of protoplasmic toxin. After entering the human body, it can coagulate protein, destroy cell protein, and damage liver and kidney. It ranks second on the list of priority control of toxic chemicals in my country. Formaldehyde has been identified as a carcinogen by the National Institutes of Cancer Research, 10g can cause death, is a banned substance in tobacco additives, and is one of the key harmful components in mainstream cigarette smoke proposed by the World Health Organization (WHO). Acetaldehyde, also known as acetaldehyde, is a colorless and easy-flowing liquid with a pungent odor and certain toxicity. It is also one of the key harmful components in mainstream cigarette smoke prop...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 李中皓杨飞刘珊珊孙莹莹邓惠敏范子彦边照阳王颖张艳革唐纲岭
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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