Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof
A composition and technology for coronary heart disease, applied in drug combination, pharmaceutical formulation, drug delivery, etc., can solve unresolved clinical problems and achieve good application prospects, clear curative effect, and low toxicity
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Embodiment 1
[0033] (1) A Chinese medicine for the treatment of coronary heart disease, which is formed by the proportioning of the following raw materials by weight:
[0034] 30 parts of lip vanilla, 25 parts of ginseng reed, 20 parts of hairy rabbit lip flower, 15 parts of an umbrella, 15 parts of Gan Mutong, 10 parts of ginkgo leaf, 10 parts of Chuanqiong, 10 parts of long-tube bat grass, 10 parts of poria cocos, tooth 5 parts of Ye Liwu and 5 parts of white milk mushroom.
[0035] (2) Preparation method:
[0036] In the first step, the ginseng reed and the rhizoma chinensis are mixed in proportion, extracted twice with n-propanol having an alcohol concentration of 70% which is equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, Then purify with ethanol for 1-2 times, combine the extracts, recover the ethanol under reduced pressure and concentrate to a paste with a relative density of 1.21-1...
Embodiment 2
[0041](1) A kind of Chinese medicine for the treatment of coronary heart disease is formed by the proportioning of following raw materials by weight: same as embodiment 1.
[0042] (2) Preparation method:
[0043] In the first step, the ginseng reed and the rhizoma chinensis are mixed in proportion, extracted twice with n-propanol having an alcohol concentration of 70% which is equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, Then purify once with ethanol, combine the extracts, recover ethanol under reduced pressure and concentrate to a paste with a relative density of 1.21-1.24 at 60°C, dry and pulverize into powder;
[0044] In the second step, an umbrella, Ganmusong, ginkgo leaves, and Chuanqiong are extracted twice with n-propanol with an alcohol concentration of 80%, and the extracts are combined, concentrated under reduced pressure, dried, and pulverized into powder, and th...
Embodiment 3
[0048] 1. Long-term toxicity test process:
[0049] Apply Wistar rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. provides) experimental medicine is set to high, medium and low three dosages, be respectively the capsule 8g / kg, 4g / kg, 2g of embodiment 1 formula / kg. Calculated according to the human dose of 0.1g / kg / day tablet, it is 80 times, 40 times and 20 times of the effective dose for human respectively; another control group is set up, which is given continuously for 90 days and 180 days by intragastric administration and part of the animals are withdrawn for 10 days. Days later, the effects on various physiological and biochemical indicators of rats were observed. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, bl...
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