Cationic nanoparticles and preparation method and application
A technology of nanoparticles and cations, applied in the field of medicine, can solve the problems of discoloration, teeth containing irritating ingredients, poor antibacterial effect, etc., and achieve the effect of good compatibility, small irritation, and strong antibacterial effect
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Embodiment 1
[0032] A preparation method of cationic nanoparticles, comprising the following steps:
[0033] (1) Dissolve octadecylamine in chloroform so that the concentration of octadecylamine is 0.6 mg / mL;
[0034] (2) Take 0.5 mL of the solution obtained in step (1), dissolve 20 mg of PLGA in the solution, stir and mix;
[0035] (3) Take 10mL of F68 aqueous solution with a concentration of 0.5%, mix it with the solution obtained in step (2), and then perform ultrasonic treatment at a temperature of 25°C for 6 times with a time interval of 9s and each treatment time of 5s , to obtain an emulsified solution containing PLGA nanoparticles;
[0036] (4) Place the emulsified solution obtained in step (3) at 40°C for 20 minutes in a vacuum rotary evaporation to remove chloroform
[0037] , to obtain a solution of cationic nanoparticles.
[0038] Take 0.1 mL of the above-mentioned cationic nanoparticle solution, dilute it 10 times with distilled water, and measure the average particle size ...
Embodiment 2
[0041] A preparation method of cationic nanoparticles, comprising the following steps:
[0042] (1) Dissolve octadecylamine in dichloromethane so that the concentration of octadecylamine is 0.8mg / mL;
[0043] (2) Take 0.5 mL of the solution obtained in step (1), dissolve 20 mg of PLGA in the solution, stir and mix;
[0044] (3) Take 10mL of F68 aqueous solution with a concentration of 0.6%, mix it with the solution obtained in step (2), and then perform ultrasonic treatment at a temperature of 25°C for 6 times with a time interval of 9s and each treatment time of 5s , to obtain an emulsified solution containing PLGA nanoparticles;
[0045] (4) Place the emulsified solution obtained in step (3) at 25°C for 40 minutes in a vacuum rotary evaporation to remove chloroform
[0046] , to obtain a solution of cationic nanoparticles.
[0047] Take 2mL of the above-mentioned cationic nanoparticle solution and place it under the condition of 37°C for 4h, 8h, 24h, 48h and 72h respectiv...
Embodiment 3
[0051] A preparation method of cationic nanoparticles, comprising the following steps:
[0052] (1) Dissolve octadecylamine in absolute ethanol so that the concentration of octadecylamine is 1mg / mL;
[0053] (2) Take 0.5mL of the solution obtained in step (1), dissolve 15mg of PLGA in the solution, stir and mix;
[0054] (3) Take 15mL of F68 aqueous solution with a concentration of 0.2%, mix it with the solution obtained in step (2), and then perform ultrasonic treatment at a temperature of 25°C for 6 times with a time interval of 9s and each treatment time of 5s , to obtain an emulsified solution containing PLGA nanoparticles;
[0055] (4) Put the emulsified solution obtained in step (3) under the condition of 37° C. for 35 minutes in a vacuum rotary evaporation to remove chloroform to obtain a cationic nanoparticle solution.
[0056] Put Streptococcus mutans (UA159) into BHI liquid medium for subculture. When the concentration of the strain is moderate and the activity is st...
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