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Method for processing crude heparin sodium product

A technology of heparin sodium and crude products, which is applied in the field of processing heparin sodium, can solve the problems of inability to develop rapidly, backwardness, and impossibility to improve the purity

Inactive Publication Date: 2017-06-30
南通天龙畜产品有限公司
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Due to fierce competition, the cost of raw materials remains high, and the purity of the pig lung extraction process cannot be improved due to traditional and backward salt solution and precipitation technologies, making it unable to develop rapidly and causing a lot of waste of resources

Method used

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Examples

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Embodiment Construction

[0005] 1. a method for processing heparin sodium crude product, is characterized in that, comprises: the pig lung of fresh pig lung or thawing is twisted into pasty material after peeling off trachea, fat, obtains pig lung slurry, to pig lung slurry Add 0.5 times the weight of the porcine lung slurry in deionized water, then add preservatives and cell activators accounting for 0.2% of the weight of the porcine lung slurry, and react intermittently at 35°C for 5 hours to obtain the first porcine lung slurry liquid, add 2 times the deionized water of the weight of the first pig lung slurry liquid in the first pig lung slurry liquid to obtain the second pig lung slurry liquid, then add 5% of the second pig lung slurry liquid weight Sodium chloride, adjust the pH to 10 with sodium hydroxide solution, and react intermittently at 30°C for 5 hours to obtain the pig lung alkaline solution; slowly heat the obtained pig lung alkaline solution to 45°C, add sodium hydroxide solution Adjus...

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Abstract

The invention relates to a method for processing crude heparin sodium. Fresh pig lungs or thawed pig lungs are twisted into a paste, added with a cell activator for catalysis, and then enzymatically hydrolyzed by biological enzymes, separated and filtered to obtain heparin sodium. The solution is then subjected to resin adsorption, elution, organic solvent precipitation, and drying to obtain crude heparin sodium. The extraction method of the crude heparin sodium product of the present invention can improve product quality and effective yield, reduce production cost, is suitable for industrial production, reduces waste discharge, and has social, environmental protection and economic benefits.

Description

technical field [0001] The invention relates to the field of processing heparin sodium, in particular to a method for processing crude heparin sodium. Background technique [0002] Heparin is a natural anticoagulant drug, which has the functions of dissolving thrombus and preventing blood coagulation. It is also the compound with the most complex molecular structure known in the world so far. Due to fierce competition, the cost of raw materials remains high, and the purity of the pig lung extraction process cannot be improved due to traditional and backward salt solution and precipitation technologies, making it unable to develop rapidly and causing a lot of waste of resources. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a method for processing crude heparin sodium. The present invention utilizes high-speed centrifugal separation technology to effectively extract heparin sodium, thereby greatly improving prod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10
CPCC08B37/0075C08B37/0003
Inventor 孙学超许春龙刘亚男许悟赟韩国栋
Owner 南通天龙畜产品有限公司
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