Compound mango leaf extract skin cream and preparation method thereof

A mango leaf and extract technology is applied in the field of compound mango leaf extract skin cream and its preparation, which can solve the problems of unsatisfactory clinical trial effect and low bioavailability, and achieve enhanced anti-inflammatory effect and low permeability. Effect

Active Publication Date: 2020-10-16
海南五世其昌生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the extremely low bioavailability of mangiferin to the human body, the clinical trials of these oral preparation products are not ideal

Method used

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  • Compound mango leaf extract skin cream and preparation method thereof
  • Compound mango leaf extract skin cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A. Raw material preparation: take fresh mango leaves as raw materials, dry them naturally or at 50°C, and crush them through a 20-mesh sieve.

[0038] B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 3L of ethyl acetate, seal and soak for 5h, extract by shaking at room temperature for 15min, and filter; repeat extraction 4 times, the green color of the extract basically disappears.

[0039]C. Methanol extraction: Take the residue extracted in step B, add 2.5L of methanol, seal and soak at 30°C for 5h, stir and extract at 55°C for 0.5h, filter while hot, repeat extraction 5 times, combine the extracts, and precipitate at room temperature 9h, finely filter with a 200-mesh filter.

[0040] D. Concentration and washing: Concentrate the filtrate of step C by vacuum rotary evaporation at 50°C to obtain about 50g of concentrated extract, add 150mL of methanol, stir and wash at 55°C for 10min, let cool, filter with a 200-mesh filter, and wash repe...

Embodiment 2

[0042] A. Raw material preparation: take fresh mango leaves as raw materials, dry them in the sun, and crush them through a 30-mesh sieve.

[0043] B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 4L of ethyl acetate, seal and soak for 4h, shake at room temperature for 10min, filter; repeat extraction 3 times, the green color of the extract basically disappears.

[0044] C. Methanol extraction: Take the residue extracted in step B, add 4L of methanol, seal and soak at 40°C for 4h, stir and extract at 60°C for 0.5h, filter while hot, repeat the extraction 4 times, combine the extracts, and precipitate at room temperature for 10h , and finely filter with a 200-mesh filter.

[0045] D. Concentration and washing: Concentrate the filtrate of step C into a concentrated extract by vacuum rotary evaporation at 65°C, add 200mL of methanol, stir and wash at 50°C for 20min, let it cool, filter with a 200-mesh filter, and wash 5 times repeatedly. Yellow-whi...

Embodiment 3

[0047] A. Raw material preparation: take fresh mango leaves as raw material, dry at 65°C, and crush through a 40-mesh sieve.

[0048] B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 2L of ethyl acetate, seal and soak for 6h, shake at room temperature for 20min, filter; repeat extraction 5 times, the green color of the extract basically disappears.

[0049] C. Methanol extraction: take the residue extracted in step B, add 2L of methanol, seal and soak at 30°C for 6h, stir and extract at 60°C for 1h, filter while hot, repeat the extraction 6 times, combine the extracts, and precipitate at room temperature for 12h. Finely filter with a 200-mesh filter.

[0050] D. Concentration and washing: Concentrate the filtrate of step C into a concentrated extract by vacuum rotary evaporation at 65°C, add 130mL of methanol, stir and wash at 50°C for 20min, let it cool, filter with a 200-mesh filter, and wash 5 times repeatedly. Yellow-white particles. The fi...

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Abstract

The invention belongs to the field of health care and daily chemicals, and in particular relates to a compound folium mangifera extract skin care cream, which takes a folium mangifera extract as a major active ingredient, as well as a preparation method thereof. The compound folium mangifera extract skin care cream provided by the invention has a good effect on preventing and treating skin itching and swelling caused by skin furuncle and mosquito bites. The skin care cream consists of the following major active ingredients in parts by weight: 1-2 parts of the folium mangifera extract, 0.8-1.2 parts of arbutin, 0.8-1.2 parts of salicylic acid and 0.8-1.2 parts of titanium dioxide; and the folium mangifera extract contains 60-70% of mangiferin. The cream, which is prepared from the mangiferin, the arbutin, the salicylic acid and the titanium dioxide in the coordination with corresponding adjuvants, can get melted and disappear rapidly after being applied to the skin, so as to keep the skin wet, moist and glossy; and the cream, on the skin itching and swelling caused by skin furuncle and mosquito bites, has obvious effects of relieving itching, diminishing inflammation and promoting skin recovery.

Description

technical field [0001] The invention belongs to the field of medical care and daily chemical products, and in particular relates to a compound mango leaf extract skin cream with mango leaf extract as the main active ingredient and a preparation method thereof. Background technique [0002] Mango (Mangifera indica L.) is a common tropical fruit in southern my country. The mango planting area in the Panxi region of Sichuan reaches more than 300,000 mu, featuring high yield and good quality, occupying the domestic late-maturing mango market, and the mango industry has become the leading industry in local agriculture. The long-term measurement and analysis by the inventor shows that the content of mangiferin (mangiferin) in mango leaves in Panxi area is as high as 2-8%, which is much higher than that in other plants such as Anemarrhena anemarrhena, and is also much higher than that in mango leaves in other production areas in my country. content of mangiferin. [0003] Mangifer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/29A61K8/368A61K8/60A61Q19/00A61P17/04
CPCA61K8/29A61K8/368A61K8/602A61K8/97A61K2800/75A61Q19/00
Inventor 韦会平尚远宏韩洪波田金凤
Owner 海南五世其昌生物科技有限公司
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