High-dispersion-carbon-nanotube photoacoustic contrast agent and preparation method thereof

A technology of carbon nanotubes and photoacoustic contrast, applied in the field of materials, can solve the problems of lack of functional groups, low dispersion, unfavorable functionalization, etc., and achieve the effect of good dispersion, strong photoacoustic signal, and easy operation

Inactive Publication Date: 2017-07-04
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a high-dispersion Carbon nanotube photoacoustic contrast agent and preparation method thereof

Method used

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  • High-dispersion-carbon-nanotube photoacoustic contrast agent and preparation method thereof
  • High-dispersion-carbon-nanotube photoacoustic contrast agent and preparation method thereof
  • High-dispersion-carbon-nanotube photoacoustic contrast agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of Highly Dispersed Carbon Nanotube Photoacoustic Contrast Agent

[0031] 1. Solution preparation

[0032] Carboxylated multi-walled carbon nanotube dispersion system: disperse 0.0322g carboxylated multi-walled carbon nanotubes in 100mL deionized water, the carboxyl content of the carboxylated multi-walled carbon nanotubes is 0.5%, the diameter is 20nm, ultrasonic 20min, stirring for 15min to make it dispersed, the length of the carboxylated multi-walled carbon nanotubes in the dispersion system after dispersion is 2 μm;

[0033] Choled polyethylene glycol solution: Dissolve 0.0052 g of cholated polyethylene glycol powder in 100 mL of deionized water, stir to dissolve it, and the molecular weight of polyethylene glycol in the cholated polyethylene glycol is 0.5 kDa.

[0034] 2. Preparation of highly dispersed carbon nanotube photoacoustic contrast agent

[0035] (1) The carboxylated multi-walled carbon nanotube dispersion system is added dropwise...

Embodiment 2

[0039] Example 2 Preparation of Highly Dispersed Carbon Nanotube Photoacoustic Contrast Agent

[0040] 1. Solution preparation

[0041] Branched polyethyleneimine (PEI) solution (Mn=10000): 2.1508g of branched polyethyleneimine (PEI) was dissolved in 100mL of deionized water, ultrasonically and stirred to dissolve;

[0042] Carboxylated multi-walled carbon nanotube dispersion system: 0.0644g carboxylated multi-walled carbon nanotubes are dispersed in 50mL deionized water, the carboxyl content of the carboxylated multi-walled carbon nanotubes is 3%, and the diameter is 30nm. Sonicate for 30 minutes, stir for 60 minutes to disperse, and the length of the carboxylated multi-walled carbon nanotubes in the dispersed system is 0.5 μm after dispersion;

[0043] Choled polyethylene glycol solution: Dissolve 0.0052 g of cholated polyethylene glycol powder in 50 mL of deionized water and stir to dissolve it. The molecular weight of polyethylene glycol in the cholated polyethylene glyco...

Embodiment 3

[0047] Example 3 Preparation of Highly Dispersed Carbon Nanotube Photoacoustic Contrast Agent

[0048] 1. Solution preparation

[0049] Tetraethylenepentamine solution: Dissolve 0.5g of tetraethylenepentamine in 100mL of deionized water, ultrasonically and stir to dissolve it;

[0050] Carboxylated multi-walled carbon nanotube dispersion system: 0.0644g carboxylated multi-walled carbon nanotubes are dispersed in 50mL deionized water, the carboxyl content of the carboxylated multi-walled carbon nanotubes is 3%, and the diameter is 30nm. Sonicate for 30 minutes, stir for 60 minutes to disperse, and the length of the carboxylated multi-walled carbon nanotubes in the dispersed system is 0.5 μm after dispersion;

[0051] Choled polyethylene glycol solution: Dissolve 0.0052 g of cholated polyethylene glycol powder in 50 mL of deionized water and stir to dissolve it. The molecular weight of polyethylene glycol in the cholated polyethylene glycol is 20 kDa.

[0052] 2. Preparation o...

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Abstract

The invention discloses a high-dispersion-carbon-nanotube photoacoustic contrast agent and a preparation method thereof. The preparation method comprises the following steps: (1) adding a carboxylated multi-wall carbon nanotube disperse system into a polyamido cationic polymer solution drop by drop during ultrasonic treatment and stirring, carrying out ultrasonic treatment for 10 to 30 min and stirring for 30 to 60 min after completion of addition, then maintaining a temperature of 60 to 90 DEG C for 20 to 36 h, carrying out cooling to 15 to 30 DEG C and then successively carrying out centrifugation, washing and precipitate dispersion so as to prepare a polyamido cationic polymer-carbon nanotube disperse system; and (2) adding a polyethylene glycol cholate into the polyamido cationic polymer-carbon nanotube disperse system prepared in the step (1) drop by drop during ultrasonic treatment and stirring so as to prepare the high-dispersion-carbon-nanotube photoacoustic contrast agent. The preparation method is simple to operate, green and environment-friendly; and the prepared high-dispersion-carbon-nanotube photoacoustic contrast agent has good dispersity, stability and biocompatibility.

Description

technical field [0001] The invention relates to the technical field of materials, and relates to a highly dispersed carbon nanotube photoacoustic contrast agent and a preparation method thereof. Background technique [0002] Photoacoustic imaging is a new nondestructive biomedical imaging method developed in recent years. Photoacoustic imaging combines the advantages of pure optical imaging with high contrast and pure ultrasonic imaging with high penetration depth, avoids the influence of light scattering in principle, and breaks through the "soft limit" of high-resolution optical imaging depth (~1mm) , which can achieve 50mm deep in vivo molecular imaging. Due to the difference in light absorption between tumor tissue and normal tissue (under the irradiation of near-infrared laser, the light absorption difference between cancerous tissue and surrounding normal tissue is at least 5 times) and biological tissues in different physiological states have different light absorpti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22
CPCA61K49/221A61K49/226
Inventor 刘颖斌谭庆刚王宁周坚李茂岚马强赵帅
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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