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A flexible biological pH sensor based on nanowire texture and its preparation method

A pH sensor and nanowire technology, applied in the field of nanowire textured flexible biological pH sensor and its preparation, can solve the problems of inability to use for a long time, allergies, surface friction, etc., to eliminate allergic and uncomfortable reactions, and avoid direct contact , the effect of avoiding interference

Active Publication Date: 2019-08-09
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are surface friction problems in practical use, which will have great problems in actual product applications, and cannot be used for a long time, and there are allergies or other safety issues in direct contact between materials and human skin.

Method used

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  • A flexible biological pH sensor based on nanowire texture and its preparation method
  • A flexible biological pH sensor based on nanowire texture and its preparation method
  • A flexible biological pH sensor based on nanowire texture and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Oxygen plasma treatment is performed on a flexible PI substrate with a thickness of 100μm. Specific parameters: vacuum degree 0.1Pa, working pressure 20Pa, working gas O 2 , Flow 20sccm, RF power 60w, room temperature treatment for 5min. Plasma treatment introduces hydrophilic groups on the surface and increases the adhesion of the surface, then cut into 1×1cm 2 Film.

[0048] (2) Design as figure 2 The photolithography template, the electrode template is prepared by ultraviolet exposure on the processed PI film, and Ti / Au electrodes with a thickness of 110nm with an interval of 3μm are deposited by electron beam evaporation. Ultraviolet exposure parameters: AZ5214 glue is baked 3min before 110℃, and exposed for 1s. Bake at 120℃ for 2min, expose for 20s, and develop for 1min. Electron beam evaporation parameters: vacuum degree 5×10 -6 mbar, Ti / Au thickness is 10 / 100nm respectively. The electrodes at both ends are led out by pressure welding. The microchannel electro...

Embodiment 2

[0053] (1) Treat a flexible PET substrate with a thickness of 100μm in oxygen plasma, with specific parameters: vacuum 0.1Pa, working pressure 20Pa, working gas O 2 , Flow 20sccm, RF power 60w, room temperature treatment for 5min. Plasma treatment introduces hydrophilic groups on the surface and increases the adhesion of the surface, then cut into 1×1cm 2 Sheets to make flexible substrates.

[0054] (2) The single-walled carbon nanotubes are processed to introduce carboxyl functional groups. The parameters are: take 15mg of single-walled carbon nanotubes and disperse them in 9mL of concentrated nitric acid (65% by mass) and 27mL of concentrated sulfuric acid (98% by mass), 110 Stir in an oil bath at ℃ for 45 minutes, wash the carbon nanotubes to neutrality, take 2mg of the dried carbon nanotubes and add them to a prepared 10ml solution of 1% sodium dodecylbenzene sulfonate (SDBS), and Disperse by ultrasonic at 300W for 60 minutes; add 300μL of the above solution to 40mL 1mol / L HC...

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Abstract

The invention discloses a flexible biological pH sensor based on nano wire texture and a preparation method thereof. The pH sensor comprises a flexible substrate, a micro channel electrode structure, an electrode lead, a nano wire texture sensitive layer, and an ion selectively penetrating membrane. Two opposite channel structures composed of electrodes are prepared on the flexible substrate through a template method. The electrodes are connected to the exterior through leads. A textured nano wire material is prepared in the channel areas of electrodes and is taken as the pH sensitive layer. The ion selectively penetrating membrane is covered on the surface of electrodes. The nano wire sensitive material is arranged on the substrate, the channel is composed of two electrodes, the electrodes are completely covered by the ion selectively penetrating membrane, the problems that an inorganic nonmetal nano wire is easily worn in a flexible wearable sensor and can be disturbed are solved, and the in-situ real-time measurement and analysis of human fluid pH value is realized.

Description

Technical field [0001] The invention belongs to the field of preparation of electrochemical sensors, and in particular relates to a nanowire-based texture flexible biological pH sensor and a preparation method thereof, which are used to realize in-situ real-time detection and analysis of human body fluids including sweat and blood, and ensure The sensor is suitable for long-term wear and accurate work of the human body. Background technique [0002] The high-efficiency and rapid detection characteristics of the new biosensor will bring a new technological revolution in the fields of biomedicine, environmental detection, food, and pharmaceutical industries. Among them, pH detection is a very important technical means in the application of biotechnology. For example, rapid and accurate detection of human blood, urine and other pH values ​​is of great significance to the treatment and prevention of human diseases. However, the current pH testing methods including pH meters, pH test...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/12
CPCG01N27/125
Inventor 王如志沈震张曼晨严辉张铭王波汪浩宋雪梅
Owner BEIJING UNIV OF TECH
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